Side Effects of Zyloprim (Allopurinol) for Kidney Damage Prevention

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Ask the experts

My husband is on 300 mg a day of zyloprim for the treatment of gout, even though to his knowledge he has never had an actual gout attack. The only way he found out was when he had a blood test done for what turned out to be a problem with his knee, that was fixed through arthroscopic surgery.  He has been on zyloprim for about 5 years.  Is this normal?  When he asks his doctor, he tells him it is to prevent any possible kidney damage.

Doctor's response

Significantly abnormally elevated uric acid blood levels can lead to damage to the tissues of the kidney (called urata nephropathy) and kidney stonesAllopurinol (zyloprim) is used to return the uric acid blood level to normal and avoid the risk of kidney damage, whether or not a patient has ever had gouty arthritis.

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Reviewed on 1/11/2018