Brand Name: Zoryve
Generic Name: roflumilast
Drug Class: Phosphodiesterase-4 Enzyme Inhibitors
What is Zoryve, and what is it used for?
Zoryve is a topical prescription cream used to treat the symptoms of plaque psoriasis in adults and children over the age of 12.
- Zoryve may be used alone or with other medications.
- Zoryve belongs to a class of drugs called PDE-4 Inhibitors, Topical.
- It is not known if Zoryve is safe and effective in children younger than 12 years of age.
Warnings
The use of Zoryve is contraindicated in the following condition:
- Moderate to severe liver impairment (Child-Pugh B or C)
What are the side effects of Zoryve?
Zoryve may cause serious side effects including:
- hives,
- difficulty breathing,
- swelling of your face, lips, tongue, or throat,
- dizziness,
- mood or behavior changes,
- anxiety,
- depression,
- trouble sleeping,
- impulsive thoughts,
- thoughts of self-harm,
- rapid and unintended weight loss,
- pain or burning when you urinate, and
- tremors
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Zoryve include:
- nausea,
- diarrhea,
- loss of appetite,
- minor weight loss,
- headache,
- dizziness,
- occasional sleep problems,
- back pain, and
- flu symptoms
Tell the doctor if you have any side effect that bothers you or that does not go away.
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What drugs interact with Zoryve?
No formal drug-drug interaction studies were conducted with Zoryve.
Drugs That Inhibit Cytochrome P450 (CYP) Enzymes
- The coadministration of roflumilast with systemic CYP3A4 inhibitors or dual inhibitors that inhibit both CYP3A4 and CYP1A2 simultaneously (e.g., erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) may increase roflumilast systemic exposure and may result in increased adverse reactions. The risk of such concurrent use should be weighed carefully against benefit.
Oral Contraceptives Containing Gestodene And Ethinyl Estradiol
- The coadministration of roflumilast with oral contraceptives containing gestodene and ethinyl estradiol may increase roflumilast systemic exposure and may result in increased side effects. The risk of such concurrent use should be weighed carefully against benefit.
Pregnancy and breastfeeding
- There are no randomized clinical trials of oral or topical roflumilast in pregnant women. Consult your doctor if you are pregnant.
- There is no information regarding the presence of Zoryve in human milk, the effects on the breastfed infant, or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Zoryve and any potential adverse effects on the breastfed infant from Zoryve or from the underlying maternal condition.

QUESTION
Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See AnswerSummary
Zoryve is a topical prescription cream used to treat the symptoms of plaque psoriasis in adults and children over the age of 12. Zoryve is contraindicated in people with moderate to severe liver impairment (Child-Pugh B or C). Serious side effects of Zoryve that require immediate medication attention include hives, difficulty breathing, swelling of your face, lips, tongue, or throat; dizziness, mood or behavior changes, anxiety, depression, trouble sleeping, impulsive thoughts, thoughts of self-harm, rapid and unintended weight loss, pain or burning when you urinate, and tremors. Consult your doctor if pregnant or breastfeeding
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What Is the Difference Between Eczema and Psoriasis?
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Psoriasis is an incurable chronic autoimmune disorder of the skin that causes patches of thick, flaky, scaly skin, mostly around the scalp, knees, and elbows, though any skin surface may be involved. Some people experience only small patches while others have red, inflamed skin and think scaly patches all over the body. The exact cause of psoriasis is not clear, but it isn’t contagious.
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Nummular Eczema vs. Ringworm: Differences
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How Do You Stop Psoriasis From Stress?
Psoriasis is an autoimmune skin disease that can be passed down (hereditary) to you from your parents or grandparents. Stress is a common factor that can trigger your psoriasis. Psoriasis has a stronger association with psychiatric disorders than other skin diseases. Stress worsens psoriasis by triggering a complex network of signals between the endocrine (hormones), nervous and immune systems.
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What Is the Main Cause of Eczema?
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What Are the Different Types and Causes of Scalp Psoriasis?
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Is Nummular Eczema an Autoimmune Disorder?
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Is Psoriasis Associated With HIV?
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What Triggers Facial Psoriasis?
Possible triggers of facial psoriasis include smoking, obesity, medications, infections, skin injury, stress, vitamin D deficiency, and stress.
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What Causes Nail Psoriasis?
Nail psoriasis is caused by the same autoimmune mechanisms as other types of psoriasis. The immune system attacks normal tissues in the body and triggers rapid cell growth.
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Can You Get Rid of Eczema?
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What Is the Best Treatment for Eczema?
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What Triggers Eczema on Hands?
Eczema is a skin condition that causes red, itchy, scaly skin. Things that trigger eczema on the hands include excessive hand washing, harsh soap, scented lotion, and other irritants.
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How Is Inverse Psoriasis Diagnosed?
Diagnosis of inverse psoriasis is typically based on medical history and a clinical examination that assesses the location and appearance of the rash.
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Is Genital Psoriasis Life-Threatening?
Although genital psoriasis is neither life-threatening nor contagious, it can be uncomfortable and more difficult to treat than other types of psoriasis.
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Is Eczema Linked to Diet?
Research has linked food allergies and eczema, and avoiding certain foods could help reduce eczema flare-ups. Learn which foods to avoid and which foods to eat if you suffer from eczema.
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Is Pustular Psoriasis an Autoimmune Disease?
Pustular psoriasis is an autoimmune disease that is characterized by yellowish pustules over the skin on an erythematous base.
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Where Does Psoriasis Usually Start?
The most common sites of psoriasis are the scalp, elbows, and knees, although psoriasis can involve any part of the body such as the face, palms, soles, and back.
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How Do You Treat Mild to Moderate Psoriasis?
Mild to moderate psoriasis is typically treated with medications and therapies that aim to reduce inflammation and slow the rapid skin cell growth associated with the condition.
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Is Erythrodermic Psoriasis Rare?
Erythrodermic psoriasis is a very rare and potentially fatal form of psoriasis that affects about 1%-2.2% percent of people with the condition.
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What Is Chronic Plaque Psoriasis?
Chronic plaque psoriasis is a chronic inflammatory skin condition characterized by well-distinguished, erythematous (red and inflamed), scaly plaques on the skin of extensor surfaces.
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What Is Generalized Pustular Psoriasis?
Generalized pustular psoriasis (GPP) is a rare, severe type of psoriasis that covers large areas of the body and characterized by pus-filled blisters rather than plaques.
-
Does Psoriasis Cause Cardiovascular Disease?
Long-lasting inflammation due to psoriasis can affect your heart and blood vessels, increasing your risk of developing cardiovascular disease, heart attack, or stroke.
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Is Psoriasis Linked to Anxiety?
Like other chronic conditions, psoriasis can take a toll on your emotional health. Anxiety can trigger or worsen psoriasis, and psoriasis can cause anxiety.
-
What Is Intertriginous Psoriasis?
Intertriginous psoriasis, also known as inverse psoriasis, is a rare type of psoriasis that occurs in skin folds, such as the armpits, under the breasts, and groin.
-
Are Psoriasis and Psoriatic Arthritis the Same?
Psoriatic arthritis is a type of inflammatory arthritis that occurs due to joint inflammation in people with psoriasis; however, not every person with psoriasis gets psoriatic arthritis.
-
What Is the Most Severe Form of Psoriasis?
Erythrodermic psoriasis (EP) or erythroderma is a severe type of psoriasis that causes extensive peeling, severe itching, and rashes across the entire surface of the body.
-
How Do I Get Rid of Eczema on My Face?
Get rid of facial eczema by using moisturizers, bathing practices, wet-wrap therapy, medications, and phototherapy.
-
Can Psoriasis Lead to Psoriatic Arthritis?
It is well established that both psoriatic arthritis and psoriasis are linked. Nearly 30 percent of people with psoriasis develop psoriatic arthritis.
-
What Is Considered Moderate Plaque Psoriasis?
Moderate plaque psoriasis is when patches cover 3%-10% of your body surface area. Learn about symptoms, causes, triggers, and treatment.
-
Is Psoriasis a COVID-19 Risk?
Psoriasis is a chronic, autoimmune, inflammatory condition that primarily affects the skin. There is no definitive link between psoriasis and an increased risk of COVID-19.
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How Does Psoriasis Affect the Cardiovascular System?
Psoriasis causes inflammation inside your body, which can damage your cardiovascular system over time and increase your risk of heart problems.
Treatment & Diagnosis
- Psoriasis FAQs
- Eczema FAQs
- A Breakthrough Treatment for Eczema
- Eczema: Dry Hands May Be Sign of Eczema
- Arthritis: Reports from 2003 Arthritis Meeting
- Psoriasis, Lupus, Rheumatoid Arthritis Share One Gene
- Psoriasis Drugs Strike Immune Targets (Raptiva, Enbrel)
- Can Eczema Be Painful?
- Can You Get Gout in Your Back?
- How Do You Get Psoriasis?
- Can Psoriasis Be Caused by Allergy?
- Is It Eczema or Psoriasis?
- Is Eczema Hereditary?
- What Are the Triggers of Psoriasis?
- Eczema Medical Treatment and Home Remedies
- Psoriasis PUVA Therapy Can Increase Melanoma Risk

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.