- What is zonisamide-oral, and how does it work (mechanism of action)?
- What brand names are available for zonisamide-oral?
- Is zonisamide-oral available as a generic drug?
- Do I need a prescription for zonisamide-oral?
- What are the side effects of zonisamide-oral?
- What is the dosage for zonisamide-oral?
- Which drugs or supplements interact with zonisamide-oral?
- Is zonisamide-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about zonisamide-oral?
What is zonisamide-oral, and how does it work (mechanism of action)?
Zonisamide is an anti-seizure medication. Zonisamide is primarily used to treat partial-seizures. Scientists do not known how exactly zonisamide works in the body. Zonisamide is presumed to work on the sodium and calcium channels in the brain cells where it controls electric-currents that are responsible for seizure activity.
The FDA approved zonisamide in March 2000.
What are the side effects of zonisamide-oral?
Common side effects of zonisamide are:
- Loss of concentration
- Loss of appetite
- Stomach ache
- Speech disturbance
- Weight loss
Serious side effects of zonisamide include:
- Psychiatric disorders such as schizophrenia
- Serious skin disorders such as Stevens-Johnson's syndrome or toxic epidermal necrolysis.
What is the dosage for zonisamide-oral?
The recommended starting dose of zonisamide is 100 mg/day. Doses may be increased 100 mg/day every 2 weeks. The usual dosage varies from 100 to 600 mg/day, administered in 1 to 2 divided doses.
Safe and effective use of zonisamide is not established for children under the age of 16.
Which drugs or supplements interact with zonisamide-oral?
Zonisamide increases the risk of lactic acid build up when combined with metformin (Glucophage). If you experience sudden weakness, heavy breathing, and increased drowsiness, contact your healthcare professional immediately.
Orlistat (Xenical) should be used with caution with zonisamide because it lowers the beneficial effects of zonisamide and increases the chances of seizures. If you experience dizziness, drowsiness, difficulty walking, nausea, vomiting, and abnormal eye movements, contact your healthcare professional immediately.
Is zonisamide-oral safe to take if I'm pregnant or breastfeeding?
There are no adequate studies done on zonisamide to determine its safe and effective use in pregnant mothers.
It is not known whether zonisamide is excreted in breast milk. It should be used with caution in females who are nursing.
What else should I know about zonisamide-oral?
What preparations of zonisamide-oral are available?
Capsules: 25, 50, and 100 mg.
How should I keep zonisamide-oral stored?
Store zonisamide capsules between 20 C and 25 C (68 F and 77 F).
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Related Disease Conditions
Seizures Symptoms and Types
Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from throughout the brain, while partial seizures are produced by electrical impulses in a small part of the brain. Seizure symptoms include unconsciousness, convulsions, and muscle rigidity.
Epilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include: losing consciousness, shaking, moving limbs on both sides of the body, lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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