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- What brand names are available for zoledronic acid?
- Is zoledronic acid available as a generic drug?
- Do I need a prescription for zoledronic acid?
- What are the uses for zoledronic acid?
- What are the side effects of zoledronic acid?
- What is the dosage for zoledronic acid?
- Which drugs or supplements interact with zoledronic acid?
- Is zoledronic acid safe to take if I'm pregnant or breastfeeding?
- What else should I know about zoledronic acid?
What are the uses for zoledronic acid?
What are the side effects of zoledronic acid?
The most common adverse reactions of Reclast include:
- Bone pain
- Muscle pain
- Pain in hands
- Pain in the feet
Other side effects include:
- Joint pain
- Urinary tract infection
- Low levels of phosphate
- Low levels of potassium
- Low blood pressure
- Low magnesium blood levels
Possible serious side effects include:
- Severe bone, joint, and muscle pain may occur.
- Low calcium levels may occur if calcium and vitamin D intake is not adequate.
- Reduced kidney function after administration of Reclast has occurred.
- Patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction.
- Bone, joint, and muscle pain also occur and low-trauma femoral fractures have been reported.
Other important but rare side effects include cases of severe allergic reactions involving:
- Swelling of tongue
- Closure of airways
What is the dosage for zoledronic acid?
- For treatment of postmenopausal osteoporosis, a single 5 mg infusion once a year is recommended.
- For prevention of postmenopausal osteoporosis the recommended dose is 5 mg every two years.
- Paget's disease of bone is treated with a single 5 mg infusion. Patients with Paget's disease should also receive 1500 mg of elemental calcium and 800 IU vitamin D daily, especially during the two weeks after the injection of Reclast.
- For prevention or treatment of steroid-induced osteoporosis, the recommended dose is 5 mg once yearly.
Which drugs or supplements interact with zoledronic acid?
- Combining Reclast with aminoglycoside antibiotics such as gentamycin or loop diuretics such as furosemide (Lasix) or bumetanide (Bumex) may lead to reduced calcium in blood.
- Reclast should be used with caution in patients who are taking drugs that affect kidney function because Reclast has been associated with reduced kidney function.
- Since Reclast contains the same active ingredient as zoledronic acid (Zometa), patients treated with Zometa should not receive Reclast.
Is zoledronic acid safe to take if I'm pregnant or breastfeeding?
- Reclast should not be administered to pregnant women. Women of childbearing age should be advised to use a reliable method of birth control.
- It is not known whether Reclast is excreted in human milk. Since many drugs are excreted in human milk, and Reclast binds to bone long-term, Reclast should not be administered to nursing women.
What else should I know about zoledronic acid?
What preparations of zoledronic acid are available?
Solution: 5 mg/100 ml
How should I keep zoledronic acid stored?
- Unopened bottles should be kept at room temperature 15 C-30 C (59 F-86 F).
- Opened bottles of solution are stable for 24 hours at 2 C-8 C (36 F-46 F).
Reclast (zoledronic acid) is an injectable drug in a class of drugs referred to as bisphosphonates. It is prescribed for the treatment of osteoporosis in postmenopausal women and men, Paget's disease of bone in men and women, osteoporosis prevention in postmenopausal women, and the treatment of steroid-induced osteoporosis. Side effects include
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.