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- What is zoledronic acid? What are the uses for zoledronic acid?
- What are the side effects of zoledronic acid?
- What is the dosage for zoledronic acid?
- Which drugs or supplements interact with zoledronic acid?
- Is zoledronic acid safe to take if I'm pregnant or breastfeeding?
- What else should I know about zoledronic acid?
What is zoledronic acid? What are the uses for zoledronic acid?
- Reclast is used for treatment of osteoporosis in men and postmenopausal women as well as Paget's disease.
- It also is used to prevent osteoporosis in postmenopausal women and treatment of steroid-induced osteoporosis.
Treatment of Osteoporosis in Postmenopausal Women
Reclast is indicated for treatment of osteoporosis in postmenopausal women. In postmenopausal women with osteoporosis, diagnosed by bone mineral density (BMD) or prevalent vertebral fracture, Reclast reduces the incidence of fractures (hip, vertebral and non-vertebral osteoporosis-related fractures). In patients at high risk of fracture, defined as a recent low-trauma hip fracture, Reclast reduces the incidence of new clinical fractures.
Prevention of Osteoporosis in Postmenopausal Women
Reclast is indicated for prevention of osteoporosis in postmenopausal women.
Reclast is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who are expected to remain on glucocorticoids for at least 12 months.
Paget's Disease of Bone
Reclast is indicated for treatment of Paget's disease of bone in men and women. Treatment is indicated in patients with Paget’s disease of bone with elevations in serum alkaline phosphatase of two times or higher than the upper limit of the age-specific normal reference range, or those who are symptomatic, or those at risk for complications from their disease.
What brand names are available for zoledronic acid?
Is zoledronic acid available as a generic drug?
Do I need a prescription for zoledronic acid?
What are the side effects of zoledronic acid?
The most common adverse reactions of Reclast include:
Other side effects include:
- Joint pain
- Urinary tract infection
- Low levels of phosphate
- Low levels of potassium
- Low blood pressure
- Low magnesium blood levels
Possible serious side effects include:
- Severe bone, joint, and muscle pain may occur.
- Low calcium levels may occur if calcium and vitamin D intake is not adequate.
- Reduced kidney function after administration of Reclast has occurred.
- Patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction.
- Bone, joint, and muscle pain also occur and low-trauma femoral fractures have been reported.
Other important but rare side effects include cases of severe allergic reactions involving:
- Swelling of tongue
- Closure of airways
What is the dosage for zoledronic acid?
- For treatment of postmenopausal osteoporosis, a single 5 mg infusion once a year is recommended.
- For prevention of postmenopausal osteoporosis the recommended dose is 5 mg every two years.
- Paget's disease of bone is treated with a single 5 mg infusion. Patients with Paget's disease should also receive 1500 mg of elemental calcium and 800 IU vitamin D daily, especially during the two weeks after the injection of Reclast.
- For prevention or treatment of steroid-induced osteoporosis, the recommended dose is 5 mg once yearly.
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Which drugs or supplements interact with zoledronic acid?
- Combining Reclast with aminoglycoside antibiotics such as gentamycin or loop diuretics such as furosemide (Lasix) or bumetanide (Bumex) may lead to reduced calcium in blood.
- Reclast should be used with caution in patients who are taking drugs that affect kidney function because Reclast has been associated with reduced kidney function.
- Since Reclast contains the same active ingredient as zoledronic acid (Zometa), patients treated with Zometa should not receive Reclast.
Is zoledronic acid safe to take if I'm pregnant or breastfeeding?
- Reclast should not be administered to pregnant women. Women of childbearing age should be advised to use a reliable method of birth control.
- It is not known whether Reclast is excreted in human milk. Since many drugs are excreted in human milk, and Reclast binds to bone long-term, Reclast should not be administered to nursing women.
What else should I know about zoledronic acid?
What preparations of zoledronic acid are available?
Solution: 5 mg/100 ml
How should I keep zoledronic acid stored?
- Unopened bottles should be kept at room temperature 15 C-30 C (59 F-86 F).
- Opened bottles of solution are stable for 24 hours at 2 C-8 C (36 F-46 F).
Reclast (zoledronic acid) is an injectable drug in a class of drugs referred to as bisphosphonates. It is prescribed for the treatment of osteoporosis in postmenopausal women and men, Paget's disease of bone in men and women, osteoporosis prevention in postmenopausal women, and the treatment of steroid-induced osteoporosis. Side effects include
- Pain in the feet or hands
Drug interactions, warnings and precautions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies, and should be discussed with your physician.
Osteopenia is a bone condition characterized by bone loss that is not as severe as in osteoporosis. Bone fracture is the typical symptom of osteopenia, though the condition may be present without symptoms. Treatment involves lifestyle modifications (quitting smoking, not drinking in excess) and ensuring an adequate intake of vitamin D and calcium.
Premature Menopause (Symptoms, Causes, and Treatments)
Premature menopause is when menopause occurs in a woman before the age of 40. Causes of premature menopause include premature ovarian failure, treatments for cancer and other conditions, surgical removal of the ovaries, or chronic diseases of the pituitary or thyroid gland, or psychiatric disorders. Treatment is directed at menopausal symptoms.
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
Paget's disease is a chronic bone disorder due to irregular breakdown and formation of bone tissue. Symptoms of Paget's disease include bone pain, headaches and hearing loss, pressure on nerves, increased head size, hip pain, and damage to cartilage of joints.
Male menopause refers to the decline in testosterone production in men. As men age, they often experience many of the same symptoms that women experience in menopause. Testosterone replacement therapy may relieve some of these symptoms.
Disease Prevention in Women
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are commonly available through your general doctor. Some specialized tests may be available elsewhere.
Treatment & Diagnosis
Medications & Supplements
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