Generic drug: goserelin acetate
Brand name: Zoladex
What is Zoladex (goserelin acetate), and how does it work?
Stage B2-C Prostatic Carcinoma
Zoladex is indicated for use in combination with flutamide for the management of locally confined Stage T2b-T4 (Stage B2-C) carcinoma of the prostate. Treatment with Zoladex and flutamide should start 8 weeks prior to initiating radiation therapy and continue during radiation therapy.
Zoladex is indicated for the management of endometriosis, including pain relief and reduction of endometriotic lesions for the duration of therapy. Experience with Zoladex for the management of endometriosis has been limited to women 18 years of age and older treated for 6 months.
Advanced Breast Cancer
Zoladex is indicated for use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women.
What are the side effects of Zoladex?
Stage B2-C Prostatic Carcinoma
The following adverse experiences were reported during a multicenter clinical trial comparing Zoladex + flutamide + radiation versus radiation alone. The most frequently reported (greater than 5%) adverse experiences are listed below:
Table 1 : ADVERSE EVENTS DURING ACUTE RADIATION
THERAPY (within first 90 days of radiation therapy)
flutamide + Zoladex + Radiation
Table 2 : ADVERSE EVENTS DURING LATE RADIATION PHASE
(after 90 days of radiation therapy)
flutamide + Zoladex + Radiation
Additional adverse event data was collected for the combination therapy with radiation group over both the hormonal treatment and hormonal treatment plus radiation phases of the study. Adverse experiences occurring in more than 5% of patients in this group, over both parts of the study, were
Zoladex has been found to be generally well tolerated in clinical trials. Adverse reactions reported in these trials were rarely severe enough to result in the patients' withdrawal from Zoladex treatment. As seen with other hormonal therapies, the most commonly observed adverse events during Zoladex therapy were due to the expected physiological effects from decreased testosterone levels. These included hot flashes, sexual dysfunction and decreased erections.
Tumor Flare Phenomenon: Initially, Zoladex, like other GnRH agonists, causes transient increases in serum levels of testosterone. A small percentage of patients experienced a temporary worsening of signs and symptoms, usually manifested by an increase in cancer-related pain which was managed symptomatically.
Isolated cases of exacerbation of disease symptoms, either ureteral obstruction or spinal cord compression, occurred at similar rates in controlled clinical trials with both Zoladex and orchiectomy. The relationship of these events to therapy is uncertain.
In the controlled clinical trials of Zoladex versus orchiectomy, the following events were reported as adverse reactions in greater than 5% of the patients.
Table 3 : TREATMENT RECEIVED
|Lower Urinary Tract Symptoms||13||8|
|Pain (worsened in the first 30 days)||8||3|
|Upper Respiratory Infection||7||2|
|Chronic Obstructive Pulmonary Disease||5||3|
|Congestive Heart Failure||5||1|
|Complications of Surgery||0||18*|
|* Complications related to surgery were reported in 18% of the orchiectomy patients, while only 3% of Zoladex patients reported adverse reactions at the injection site. The surgical complications included scrotal infection (5.9%), groin pain (4 .7%), wound seepage (3.1%), scrotal hematoma (2.8%), incisional discomfort (1.6%) and skin necrosis (1.2%).|
The following additional adverse reactions were reported in greater than 1% but less than 5% of the patients treated with Zoladex:
- CARDIOVASCULAR - arrhythmia, cerebrovascular accident, hypertension, myocardial infarction, peripheral vascular disorder, chest pain;
- CENTRAL NERVOUS SYSTEM - anxiety, depression, headache;
- GASTROINTESTINAL - constipation, diarrhea, ulcer, vomiting;
- HEMATOLOGIC - anemia;
- METABOLIC/NUTRITIONAL - gout, hyperglycemia, weight increase;
- MISCELLANEOUS - chills, fever;
- UROGENITAL - renal insufficiency, urinary obstruction, urinary tract infection, breast swelling and tenderness.
As would be expected with a drug that results in hypoestrogenism, the most frequently reported adverse reactions were those related to this effect.
Table 4 : TREATMENT RECEIVED
|Application Site Reaction||6||-|
The following adverse events not already listed above were reported at a frequency of 1% or greater, regardless of causality, in Zoladex-treated women from all clinical trials:
- WHOLE BODY – allergic reaction, chest pain, fever, malaise;
- CARDIOVASCULAR - hemorrhage, hypertension, migraine, palpitations, tachycardia;
- DIGESTIVE - anorexia, constipation, diarrhea, dry mouth, dyspepsia, flatulence;
- HEMATOLOGIC - ecchymosis;
- METABOLIC AND NUTRITIONAL - edema;
- MUSCULOSKELETAL - arthralgia, joint disorder; CNS - anxiety, paresthesia, somnolence, thinking abnormal;
- RESPIRATORY - bronchitis, cough increased, epistaxis, rhinitis, sinusitis;
- SKIN - alopecia, dry skin, rash, skin discoloration;
- SPECIAL SENSES - amblyopia, dry eyes;
- UROGENITAL - dysmenorrhea, urinary frequency, urinary tract infection, vaginal hemorrhage.
The following adverse events were reported at a frequency of 5% or greater in premenopausal women presenting with dysfunctional uterine bleeding in Trial 0022 for endometrial thinning. These results indicate that headache, hot flushes and sweating were more common in the Zoladex group than in the placebo group.
Table 5 : ADVERSE EVENTS REPORTED AT A FREQUENCY OF 5%
OR GREATER IN Zoladex AND PLACEBO TREATMENT GROUPS OF TRIAL 0022
|ADVERSE EVENT||Zoladex 3.6 mg
|Skin and appendages|
The adverse event profile for women with advanced breast cancer treated with Zoladex is consistent with the profile described above for women treated with Zoladex for endometriosis. In a controlled clinical trial (SWOG–8692) comparing Zoladex with oophorectomy in premenopausal and perimenopausal women with advanced breast cancer, the following events were reported at a frequency of 5% or greater in either treatment group regardless of causality.
Table 6 : TREATMENT RECEIVED
(n=57) % of Pts.
(n=55) % of Pts.
In the Phase II clinical trial program in 333 pre- and perimenopausal women with advanced breast cancer, hot flashes were reported in 75.9% of patients and decreased libido was noted in 47.7% of patients. These two adverse events reflect the pharmacological actions of Zoladex.
Injection site reactions were reported in less than 1% of patients.
Hormone Replacement Therapy
Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/or progestins) to Zoladex may decrease the occurrence of vasomotor symptoms and vaginal dryness associated with hypoestrogenism without compromising the efficacy of Zoladex in relieving pelvic symptoms. The optimal drugs, dose and duration of treatment has not been established.
Changes In Bone Mineral Density
- After 6 months of Zoladex treatment, 109 female patients treated with Zoladex showed an average 4.3% decrease of vertebral trabecular bone mineral density (BMD) as compared to pretreatment values. BMD was measured by dual-photon absorptiometry or dual energy x-ray absorptiometry.
- Sixtysix of these patients were assessed for BMD loss 6 months after the completion (posttherapy) of the 6- month therapy period.
- Data from these patients showed an average 2.4% BMD loss compared to pretreatment values.
- Twenty-eight of the 109 patients were assessed for BMD at 12 months posttherapy. Data from these patients showed an average decrease of 2.5% in BMD compared to pretreatment values. These data suggest a possibility of partial reversibility.
- Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/or progestins) to Zoladex is effective in reducing the bone mineral loss which occurs with Zoladex alone without compromising the efficacy of Zoladex in relieving the symptoms of endometriosis. The optimal drugs, dose and duration of treatment has not been established.
Changes In Laboratory Values During Treatment
- Plasma Enzymes: Elevation of liver enzymes (AST, ALT) have been reported in female patients exposed to Zoladex (representing less than 1% of all patients).
- Lipids: In a controlled trial, Zoladex therapy resulted in a minor, but statistically significant effect on serum lipids. In patients treated for endometriosis at 6 months following initiation of therapy, danazol treatment resulted in a mean increase in LDL cholesterol of 33.3 mg/dL and a decrease in HDL cholesterol of 21.3 mg/dL compared to increases of 21.3 and 2.7 mg/dL in LDL cholesterol and HDL cholesterol, respectively, for Zoladex-treated patients. Triglycerides increased by 8.0 mg/dL in Zoladex-treated patients compared to a decrease of 8.9 mg/dL in danazol-treated patients.
- In patients treated for endometriosis, Zoladex increased total cholesterol and LDL cholesterol during 6 months of treatment. However, Zoladex therapy resulted in HDL cholesterol levels which were significantly higher relative to danazol therapy. At the end of 6 months of treatment, HDL cholesterol fractions (HDL2 and HDL2) were decreased by 13.5 and 7.7 mg/dL, respectively, for danazol-treated patients compared to treatment increases of 1.9 and 0.8 mg/dL, respectively, for Zoladex-treated patients.
The following adverse reactions have been identified during post-approval use of Zoladex. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
- Bone Mineral Density: Osteoporosis, decreased bone mineral density and bone fracture in men.
- Cardiovascular: Deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and transient ischemic attack have been observed in women treated with GnRH agonists. Although a temporal relationship was reported in some cases, most cases were confounded by risk factors or concomitant medication use. It is unknown if there is a causal association between the use of GnRH analogs and these events.
- Ovarian Cyst: Ovarian cyst formation and, in combination with gonadotropins, ovarian hyperstimulation syndrome (OHSS).
- Changes in Blood Pressure: Hypotension and hypertension have been reported. These changes are usually transient, resolving either during continued therapy or after cessation of therapy.
- Pituitary Apoplexy and Tumors: Pituitary apoplexy (a clinical syndrome secondary to infarction of the pituitary gland) and pituitary adenoma have been diagnosed. Most of the pituitary apoplexy cases occurred within 2 weeks of the first dose, and some occurred within the first hour. In these cases, pituitary apoplexy has presented as sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status, and sometimes cardiovascular collapse. Immediate medical attention has been required. Pituitary tumors have been reported.
- Acne: Usually within one month of starting treatment.
- Other Adverse Reactions: Psychotic disorders, convulsions and mood swings.
What is the dosage for Zoladex?
- Zoladex, at a dose of 3.6 mg, should be administered subcutaneously every 28 days into the anterior abdominal wall below the navel line using an aseptic technique under the supervision of a physician.
- While a delay of a few days is permissible, every effort should be made to adhere to the 28-day schedule.
Stage B2-C Prostatic Carcinoma
- When Zoladex is given in combination with radiotherapy and flutamide for patients with Stage T2b- T4 (Stage B2-C) prostatic carcinoma, treatment should be started 8 weeks prior to initiating radiotherapy and should continue during radiation therapy.
- A treatment regimen using a Zoladex 3.6 mg depot 8 weeks before radiotherapy, followed in 28 days by the Zoladex 10.8 mg depot, can be administered. Alternatively, four injections of 3.6 mg depot can be administered at 28-day intervals, two depots preceding and two during radiotherapy.
- For the management of advanced prostate cancer, Zoladex is intended for long-term administration unless clinically inappropriate.
- For the management of endometriosis, the recommended duration of administration is 6 months. Currently, there are no clinical data on the effect of treatment of benign gynecological conditions with Zoladex for periods in excess of 6 months.
- Retreatment cannot be recommended for the management of endometriosis since safety data for retreatment are not available.
- If the symptoms of endometriosis recur after a course of therapy, and further treatment with Zoladex is contemplated, consideration should be given to monitoring bone mineral density.
- Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/or progestins) to Zoladex is effective in reducing the bone mineral loss which occurs with Zoladex alone without compromising the efficacy of Zoladex in relieving the symptoms of endometriosis.
- The addition of Hormone Replacement Therapy may also reduce the occurrence of vasomotor symptoms and vaginal dryness associated with hypoestrogenism. The optimal drugs, dose and duration of treatment has not been established.
- For use as an endometrial-thinning agent prior to endometrial ablation, the dosing recommendation is one or two depots (with each depot given four weeks apart).
- When one depot is administered, surgery should be performed at four weeks. When two depots are administered, surgery should be performed within two to four weeks following administration of the second depot.
- For the management of advanced breast cancer, Zoladex is intended for long-term administration unless clinically inappropriate.
Renal Or Hepatic Impairment
- No dosage adjustment is necessary for patients with renal or hepatic impairment.
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What drugs interact with Zoladex?
- No formal drug-drug interaction studies have been performed. No confirmed interactions have been reported between Zoladex and other drugs.
Drug/Laboratory Test Interactions
- Administration of Zoladex in therapeutic doses results in suppression of the pituitary-gonadal system.
- Because of this suppression, diagnostic tests of pituitary-gonadotropic and gonadal functions conducted during treatment and until the resumption of menses may show results which are misleading. Normal function is usually restored within 12 weeks after treatment is discontinued.
Is Zoladex safe to use while pregnant or breastfeeding?
- Zoladex is contraindicated during pregnancy unless Zoladex is being used for palliative treatment of advanced breast cancer. There are no adequate and well-controlled studies in pregnant women using Zoladex.
- Based on mechanism of action in humans and findings of increased pregnancy loss in animal studies, Zoladex can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, the patient should be apprised of the potential hazard to the fetus. There is an increased risk for pregnancy loss due to expected hormone changes that occur with Zoladex treatment.
- It is not known if goserelin is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Zoladex, a decision should be made to either discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Zoladex (goserelin acetate) implant is a GnRH agonist used to treat advanced breast cancer, prostate cancer, endometriosis, and endometrial thinning. Serious side effects vary depending on the condition treated.
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BRCA genes (BRCA 1 and 2, when normal, repair damaged DNA) are among the genetic mutations linked to breast cancer, ovarian cancer, and other cancers when mutated. Every woman with a BRCA mutation is at high risk for breast cancer, irrespective of whether she has a family history of breast cancer or not. By age 80, a woman with a BRCA mutation has about an 80% chance of developing breast cancer. BRCA1 and BRCA2 gene mutations also increase the risk of ovarian cancer, by 54% and 23%, respectively.
HER2-Positive Breast Cancer
In about 10%-20% of breast cancers, the cancer cells test positive for HER2, sometimes referred to as the HER2/neu protein. HER2 is a growth-promoting protein located on the surface of some cancer cells. HER2-positive breast cancers tend to grow more rapidly and spread more aggressively than breast cancers that are HER2-negative. Doctors do not know what specifically causes some breast cancers to express this protein while others do not.
Breast Cancer Treatment by Stage
Treatment of breast cancer depends upon the stage of the cancer at the time of diagnosis. Some of the various treatments include: hormone therapy, radiation therapy, surgery, chemotherapy, HER2-targeted therapy, neoadjuvant therapy, and adjuvant therapy.
What Are the 4 Stages of Breast Cancer?
The four stages of breast cancer include Stage I, Stage II, Stage III, and Stage IV. There is one more stage called stage 0 or carcinoma in situ. It means the initial stage where the cancerous cells are confined to their origin and have not acquired the “invasive” character yet.
What Are the Five Warning Signs of Prostate Cancer?
Prostate cancer primarily affects men over 50, but is easy to treat if found early. Learn the signs of prostate cancer, what causes prostate cancer, how doctors diagnose prostate cancer, and how they treat prostate cancer.
Prostate Cancer Treatment: Focal Therapy and Other Experimental Treatments
Several new and experimental treatments for prostate cancer are under study, including treatments that use ultrasound, lasers, tissue-freezing gas, and new ways of administering radiation. These new methods are types of focal therapy, that is, treatment focused on the cancer cells in the prostate, rather than systemic therapy that administers medications or other treatments to the whole body with the aim of treating the prostate.
Breast Cancer in Young Women
About 5% of cases of breast cancer occur in women under the age of 40 years old. Some risk factors for breast cancer in young women include a personal history of breast cancer or breast disease, family history of breast cancer, prior radiation therapy, and the presence of BRCA1/BRCA2 gene mutations. Breast self-exams, clinical breast exams, and screening mammograms may help detect breast cancer. Treatment may include surgery, chemotherapy, radiation, and hormone therapy.
What Are The Five Warning Signs Of Breast Cancer?
The majority of breast cancer patients first seek diagnosis because of a lump on the breast. This is one of the five warning signs of breast cancer. Others include changes in the nipple, changes in the breast skin and other symptoms.
The early signs of prostate cancer
Prostate cancer in its early stages usually causes no signs and symptoms. Screening can help detect the cancer early.
What Questions Should I Ask My Doctor About Breast Cancer?
A diagnosis of breast cancer can be overwhelming, so it's important to write down all your questions before meeting with your doctor.
Breast Cancer Growth Rate
The available evidence suggests that breast cancer may begin to grow around 10 years before it is detected. However, the time for development differs from tumor to tumor.
How Quickly Do Symptoms of Inflammatory Breast Cancer Appear?
Inflammatory breast cancer (IBC) is a rare type of breast cancer accounting for around 1 to 5 percent of all breast cancer cases. There are three main parts in a breast: lobules, ducts and connective tissue. The milk-producing glands form the lobules. Milk formed in the lobules is carried to the nipples through tube-like channels called the ducts.
What Are the 4 Stages of Prostate Cancer?
Prostate cancer is cancer that develops in the prostate glands of men. It is one of the most common types of cancer. It is usually seen in men older than 50 years of age. The prostate is a small walnut-shaped gland in men that produces seminal fluid. This fluid nourishes and transports sperm.
What Is the Newest Treatment for Breast Cancer?
Targeted therapies are a newer form of breast cancer treatment. They can be used alone or along with other therapies. Targeted therapies directly target cancer cells or specific processes that contribute to the growth of cancer cells. Target therapy often has fewer side effects.
What Are the Main Causes of Prostate Cancer?
Breast Cancer and Coping With Stress
Being diagnosed with breast cancer is stressful. Learning relaxation techniques, exercising, eating well, getting adequate sleep, receiving psychotherapy, and maintaining a positive attitude can help you cope. Creating documents, such as an advance directive, living will, and durable power of attorney will outline your wishes in the event that you are no longer able to make decisions regarding your care.
Breast Cancer Clinical Trials
Breast cancer clinical trials are research programs designed to evaluate new medical treatments, drugs, or devices for the treatment of breast cancer. Clinical trials are designed to test the safety and efficacy of new treatments as well as assess potential side effects. Clinical trials also compare new treatment to existing treatments to determine if it's any better. There are many important questions to ask your doctor before taking part in a breast cancer clinical trial.
How Can You Tell if a Guy Has Breast Cancer?
A breast tumor or cancer is suspected if the guy has a hard lump underneath the nipple and areola. Male breast cancer exhibits the same symptoms as female breast cancer, including a lump. Male breast cancer may also cause skin changes around the nipple.
How Do I Know If I Have Endometriosis?
Approximately, one-third of the women with endometriosis remain asymptomatic. Severe pain during menses may be the first sign of endometriosis. Other symptoms that you may experience include heavy periods, low back pain, cramps, pain during intercourse and other symptoms.
What Are The Reasons Of Breast Cancer?
Breast cancer is a multifactorial disease that can be caused by genetic and environmental factors. Experts are not yet fully aware of what may be the exact reason for breast cancer. The chances of getting breast cancer depend on the person’s age, personal history, genetic factors, and diet.
What Is the Latest Treatment for Prostate Cancer?
Prostate cancer affects 1 in 5 men. Learn how it is diagnosed and treated by doctors.
Estimating Breast Cancer Risk: Questions and Answers
As breast cancer is the most diagnosed non-skin cancer in American women, it is important to know your breast cancer risk. Risk factors include age, age at menarche, age at first live birth, history of breast abnormalities, breast biopsies, race, and history or breast cancer among first-degree relatives.
What Is the Sentinel Lymph Node in Breast Cancer?
The first nodes in the axilla affected by breast cancer are known as sentinel or guardian lymph nodes. A positive sentinel lymph node biopsy or SLNB indicates that the cancer is no longer in situ.
Can Prostate Cancer Be Detected by a Blood Test?
Prostate cancer develops in the prostate gland of men. It is one of the most common types of cancer. It is usually seen in men older than 50 years of age. The prostate is a small walnut-shaped gland that produces seminal fluid required to nourish and transports sperm. Prostate cancer develops slowly. More often, it is confined to the prostate gland, requiring minimal or no treatment.
How Can You Detect Breast Cancer Early?
Breast cancer develops from the cells of the breasts and can spread to other parts of the body (metastasis). It is one of the most common cancers diagnosed in women in the United States. A lump in the breast or armpit is often the first sign. Treatment success depends largely on early detection.
What Are the Risk Factors for Developing Breast Cancer?
Breast cancer refers to the uncontrolled growth of cells within the breast. The risk factors for developing breast cancer include age, genetics, family history, personal history, menstrual history, breast density, previous radiation therapy, ethnicity, body weight, physical activity level, reproductive history, alcohol consumption and hormone pill use.
Genetic Testing: Families With Breast Cancer
Breast cancer can be a killer and the decision to get tested to see if a patient is prone to the disease should be discussed with a doctor -- particularly if the woman has a history of breast cancer in her family. Genetic testing can only tell so much about breast cancer risk, however.
What Happens If You Are Diagnosed With Prostate Cancer?
A diagnosis with prostate cancer does not mean that a person’s life has come to a full stop. Many people with prostate cancer, if diagnosed early, go on to live for many years. If the disease is diagnosed in very early stages, the doctor may only keep the patient under surveillance and treat as required. However, the patient must make some changes in their life during and after the treatment.
How Is Prostate Cancer Screening Done?
There are no standard or routine screening tests for prostate cancer. Studies are being done to find ways to make prostate-specific antigen (PSA) testing more accurate for early cancer detection.
Are There Any Clinical Trials for Breast Cancer?
Breast cancer is the second most common cancer among American women. Around 250,000 women and 2,300 men are diagnosed with breast cancer each year in the United States. Each year, breast cancer kills around 42000 women and 510 men in the United States.
How Does a Doctor Diagnose Prostate Cancer?
The prostate gland or prostate is a part of the male reproductive system. It is a small (almost walnut-sized) gland located just below the bladder and in front of the rectum (the last part of the large bowel), surrounding the urethra (the tube carrying urine out of the bladder). The prostate has two main functions: producing and storing fluid that helps make semen and regulating bladder control.
Eight Early Signs of Breast Cancer
Breast cancer is the second most common cancer affecting women in the United States (next to some types of skin cancer that are most common). Screening tests can help you identify if you have the condition.
How Common Is Breast Cancer in Men?
Breast cancer is more common in women. However, men can get breast cancer too. The chances of occurrences of breast cancer in men are rare. Out of every 100 breast cancer diagnosed in the United States, 1 is found in a man.
What Are the Risk Factors for Prostate Cancer?
All men are at risk of prostate cancer; however, some men are at more risk than others. Apart from being male, current risk factors for prostate cancer
How Does Breast Cancer Start?
Breast cancer develops in the cells of the breasts and can spread to other parts of the body (metastasis). It is one of the most common cancers diagnosed in women in the US. Although extremely rare, breast cancer can sometimes occur in men. Breast cancer forms when there are changes or mutations in the deoxyribonucleic acid (DNA), which can cause normal breast cells to become cancerous.
What Does Breast Cancer in a Man Feel Like?
Male breast cancer is rare and affects 2.7 out of 100,000 African American men and 1.9 out of 100,000 Caucasian men in the United States.
When Should You Screen for Prostate Cancer?
Screening for prostate cancer helps detecta tumor early, enabling timely treatment and prevention of any complications. According to the American Cancer Society (ACS), the decision to get screened should be made by men in consultation with their doctor. The doctor needs to counsel the men about the uncertainties involved in the screening process, the risks and potential benefits of getting screened for prostate cancer.
Treatment & Diagnosis
- Breast Cancer
- Breast Cancer Husband
- Prostate Cancer
- Breast Cancer: Mother-daughter relationships
- Inflammatory Breast Cancer
- Breast Cancer
- Breast Cancer: Early Diagnosis and Prevention
- Breast Cancer Treatment Update
- Prostate Cancer Treatment Update
- Breast Cancer: A Feisty Women's Discussion
- Breast Cancer: Early Stage Treatments
- Breast Cancer: Clinical Trials - Today's Cutting Edge
- Breast Cancer, Metastatic: Treatment Goals and Therapy Options -- Harold J. Burstein, MD
- Breast Cancer: The Male View on Survival and Support
- Breast Cancer FAQs
- Endometriosis FAQs
- Prostate Cancer FAQs
- Advanced Breast Cancer in Young Women Increasing
- Angelina Jolie's Mastectomy
- Stress and Aggressive Breast Cancer: Cause or Effect?
- Breast Cancer Risk - Reduced With Exercise
- Prostate Cancer - New Criteria
- Prostate Cancer Risk May Be Lowered By Vitamin E
- Herceptin Metastatic Breast Cancer Treatment
- Hormone Therapy in Survivors of Breast Cancer
- Breast Cancer: Types of Breast Cancer
- Elizabeth Edwards has Breast Cancer Alert
- Breastfeeding -- Protection from Breast Cancer?
- Exercise Improves Breast Cancer Survival
- Does Positive Additude Affect Breast Cancer?
- What Is the Prostate Cancer TNM Stage?
- How Common and Dangerous Is Male Breast Cancer?
- Is Prostate Cancer Genetic?
- How Many Breast Cancer Deaths Are there Each Year?
- Where Can Breast Cancer Spread To?
- Why Is Breast Cancer More Common in Females than Males?
- How Much Breast Cancer is Genetic?
- How Long Can Breast Cancer Patients Live?
- Who Does Breast Cancer Affect?
- What Does Prostate Cancer Do to You?
- How Do You Develop Prostate Cancer?
- What Are the Early Signs of Prostate Cancer?
- How Does Breast Cancer Form?
- How Many Breast Cancer Stages Are There?
- Does Endometriosis Cause Infertility?
- Facts on Breast Cancer Causes, Risk Factors, and Types
- Breast Cancer Symptoms and Signs
- Breast Cancer Detection
- Breast Cancer Treatment
- Prostate Cancer- The Importance of a PSA Test
- Breast Cancer and Kylie Minogue - Audio Podcast
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