GENERIC NAME: ZAFIRLUKAST - ORAL (ZA-fir-LOO-kast)
BRAND NAME(S): Accolate
Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage
USES: Zafirlukast is used to prevent asthma symptoms and to decrease the number of asthma attacks in people 5 and older. It helps make breathing easier by reducing swelling (inflammation) in the airways. Regular use of this medication can help control your asthma, improve your ability to exercise, and decrease the number of times you need to use your rescue inhaler.This medication works by blocking the activity of natural substances (leukotrienes) that may cause or worsen asthma. This medication does not work immediately and is not used to treat sudden asthma attacks.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used for hay fever and to prevent breathing problems while exercising.
HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start taking zafirlukast and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.Take this medication by mouth, usually twice a day or as directed by your doctor. Zafirlukast should be taken on an empty stomach at least 1 hour before or 2 hours after meals. Your dosage is based on your age, medical condition and response to therapy.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.Do not increase or decrease your dose or stop using this medication without consulting your doctor. Continue to take other medications for asthma as directed by your doctor. This medication works over time and is not meant to relieve sudden attacks of asthma. Therefore, if an asthma attack occurs, use your quick-relief inhaler as prescribed.It may take 1 to 2 weeks before you feel the full benefit of this medication. Inform your doctor if your condition (e.g., asthma symptoms, number of times you use your rescue inhaler) persists or worsens.
SIDE EFFECTS: Headache, sore throat, trouble sleeping, malaise, and nausea may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This drug may rarely cause serious (possibly fatal) liver disease. Seek immediate medical attention if you notice any of the following unlikely but very serious side effects: severe stomach/abdominal pain, persistent nausea/vomiting, unusual tiredness, yellowing of the eyes/skin, dark urine.If your doctor determines that you have experienced liver problems from this medication, do not take it again.Tell your doctor immediately if any of these rare but very serious side effects occur: mental/mood changes (e.g., agitation, aggression, hallucinations, abnormal dreams, depression, suicidal thoughts/suicide), worsening shortness of breath, tingling of the hands/feet, muscle/joint aches, coughing up blood, swelling of the hands/feet, chest pain, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat).A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or to other leukotriene blockers (e.g., montelukast); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially headache, diarrhea and nausea.This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Other medications can affect the removal of zafirlukast from your body, which may affect how zafirlukast works. Examples include macrolide antibiotics (such as erythromycin), among others.This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include theophylline, warfarin, among others.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., liver function tests) may be performed from time to time to check for side effects. Consult your doctor for more details.Learn to use a peak flow meter, use it daily, and promptly report worsening asthma (such as readings in the yellow or red range or increased use of quick-relief inhalers).Avoid allergens, irritants, smoking, and other factors that make asthma worse.Most people with asthma should receive a flu shot annually. Discuss with your doctor.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).
Information last revised December 2013. Copyright(c) 2013 First Databank, Inc.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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