- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: yohimbine
Brand Names: Aphrodyne, Yocon
Drug Class: Herbals
What is yohimbine, and what is it used for?
Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions or psychological origin. There are, however, limited data on its efficacy, and more effective drugs such as phosphodiesterase-5 inhibitors are available to treat erectile dysfunction.
Yohimbine is a plant alkaloid isolated from the bark of Pausinystalia yohimbine, an evergreen tree native to central and western Africa. Yohimbine hydrochloride is a standardized form of yohimbine and is available as a prescription drug in the U.S.
Yohimbe is the P. yohimbine bark extract and is used in many herbal supplements sold over the counter. There is very little research on the safety and efficacy of yohimbe as a dietary supplement and currently, yohimbine is banned in many countries.
Yohimbine works by blocking alpha-2 adrenergic receptors, protein molecules on nerve cells that are stimulated by norepinephrine. This reduces sympathetic nervous system activity (adrenergic) and increases parasympathetic activity (cholinergic), resulting in increased blood flow into the penis and reduced outflow of blood, which help maintain erection.
- Do not use yohimbine in the following conditions:
- Yohimbine should not be used by women and children.
- Do not take yohimbine concurrently with foods rich in the amino acid tyramine, such as liver, cheese and red wine.
- Do not use yohimbine concurrently with other stimulant-like substances such as caffeine and ephedrine alkaloids. There have been reports of kidney failure, seizures, and death due to such combinations in dietary supplements.
What are the side effects of yohimbine?
Common side effects of yohimbine include:
- Worsening of panic attacks
- Seizure (with high doses)
- Increase in blood pressure
- Rapid heart rate (tachycardia)
- Prolonged or painful erection (priapism)
- Hypersensitivity reactions
- Reduced urine output
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of yohimbine?
- 5.4 mg
- 0.5-1 tablet/caplet three times daily
The suggested treatment period is no more than 10 weeks.
- Safety and efficacy not established
What drugs interact with yohimbine?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of yohimbine include:
- selegiline transdermal
- Yohimbine has serious interactions with at least 30 different drugs.
- Yohimbine has moderate interactions with at least 168 different drugs.
- Mild interactions of yohimbine include:
- American ginseng
- yerba mate
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
What else should I know about yohimbine?
- Take yohimbine in the standardized form of tablets, only if prescribed by your physician and exactly as instructed.
- Store safely out of reach of children.
- Avoid taking yohimbine/yohimbe extract that is available as herbal supplement, natural products are not necessarily safe.
- Herbal supplements do not undergo rigorous evaluation by the FDA for safety and efficacy. There may very often be discrepancy between the labeling and the actual yohimbine content in herbal supplements. A study that analyzed 49 supplements with yohimbine found that only three of them contained the amount of yohimbine advertised on the label.
Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions or psychological origin. Yohimbine has also been used as a street drug, promoted as an aphrodisiac, hallucinogen, and for weight loss with little scientific evidence Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions, or psychological origin. Yohimbine should not be used by women and children. Yohimbine is not for use in women and pregnant or nursing women certainly should not take it.
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How Quickly Does Prostate Cancer Spread?
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Is Drinking a Lot of Water Good for Your Prostate?
Doctors recommend drinking six to eight glasses of water (or 1.5 to 2 liters) daily. For prostate problems, limit water intake before going to bed at night. This will keep you from waking up at night to urinate repeatedly.
Prostatitis (Inflammation of the Prostate Gland)
Prostatitis is an inflammation of the prostate gland. Signs and symptoms of prostatitis include painful or difficulty urinating; fever; chills; body aches; blood in the urine; pain in the rectum, groin, abdomen, or low back; and painful ejaculation or sexual dysfunction. Causes of prostatitis include STDs, bacteria from urinary tract infections, or E. coli. Treatment for prostatitis depends on if it is a bacterial infection or chronic inflammation of the prostate gland.
What Are the First Signs of Prostate Problems?
The first signs and symptoms of prostate disorder usually include problems with urination. Please consult your doctor if you experience any of the signs and symptoms to avoid the worsening of the prostate problems.
Erectile Dysfunction (ED, Impotence)
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Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
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Early-Stage Prostate Cancer Treatment
If prostate cancer is detected early and appears to be slow-growing, invasive procedures, chemotherapy, radiation and other approaches can sometimes do more harm than good. Many prostate cancer treatments come with side effects, like incontinence or impotence, so it’s in the patient’s interest to put off invasive treatments as long as is medically safe. Active surveillance is where doctors "watch and wait" for changes that could prompt medical intervention.
Do Urologists Treat Erectile Dysfunction?
Urologists are the doctors that can examine, diagnose and treat your erectile dysfunction (ED).
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Prostate Cancer Treatment: Chemotherapy, Bone-Targeted and Immune Therapy
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Is Erectile Dysfunction Always Permanent?
Erectile dysfunction is defined as your inability to get or maintain an erection when you want to. Erectile dysfunction is treatable with counseling, medications, injections, physical devices, and other medical treatments.
Can Prostate Cancer Be Detected by a Blood Test?
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Prostate Cancer Treatment: Hormonal Therapy
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Prostate Cancer: Radical Prostatectomy Surgery
Radical prostatectomy, or surgical removal of the entire prostate gland, isn’t typically the first choice in prostate cancer treatment. Sometimes a radical approach is necessary to keep the cancer from metastasizing, however. Some cases are too severe or diagnosed too late for drugs or radiation to have much effect. In these cases, treatment teams may opt for a radical prostatectomy, despite potential side effects like impotence and incontinence.
Where Is the Prostate?
The prostate gland, commonly known as the prostate, is one of the male reproductive organs located just below the bladder, above the penis, and in front of the rectum. It is connected to the penis by a tube (urethra) that empties urine from the bladder. The size and shape of the prostate are similar to a walnut.
How Can I Make My Prostate Strong?
You can strengthen a weak prostate by eating healthy, staying active, maintaining a healthy weight, managing stress, and getting enough sleep.
Prostate Cancer: Radiation, Brachytherapy and Radiopharmaceuticals
Radiation treatment for prostate cancer is a powerful tool at doctors’ disposal. Using radiation vs. surgery or other invasive treatments to kill cancer cells may still cause side effects, but ideally they are less severe. Radiation therapy can be performed via external beam therapy (EBRT) or the placement of radioactive seeds into the prostate (prostate brachytherapy) or using radioactive drugs (radiopharmaceuticals).
What Are the 4 Stages of Prostate Cancer?
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What Is the Latest Treatment for Prostate Cancer?
Prostate cancer affects 1 in 5 men. Learn how it is diagnosed and treated by doctors.
How Do You Fix Erectile Dysfunction at 50?
Erectile dysfunction isn’t necessarily a normal part of aging. Fix erectile dysfunction at 50 by making lifestyle changes, getting psychological help, getting medical or mechanical treatment, or considering surgery.
When Should You Screen for Prostate Cancer?
Screening for prostate cancer helps detecta tumor early, enabling timely treatment and prevention of any complications. According to the American Cancer Society (ACS), the decision to get screened should be made by men in consultation with their doctor. The doctor needs to counsel the men about the uncertainties involved in the screening process, the risks and potential benefits of getting screened for prostate cancer.
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What Are the Main Causes of Prostate Cancer?
The exact cause of prostate cancer is not known. Studies have revealed that prostate cancer occurs when the deoxyribonucleic acid (DNA) or genetic material of a normal prostate cell undergoes a sudden and abnormal change called a mutation.
What Are the Risk Factors for Prostate Cancer?
All men are at risk of prostate cancer; however, some men are at more risk than others. Apart from being male, current risk factors for prostate cancer include the following.
What Is Open Retropubic Prostatectomy?
Retropubic prostatectomy is a surgical treatment for patients with localized to advanced prostate cancer, in which the prostate and surrounding tissues are removed during the treatment.
How Does a Doctor Diagnose Prostate Cancer?
The prostate gland or prostate is a part of the male reproductive system. It is a small (almost walnut-sized) gland located just below the bladder and in front of the rectum (the last part of the large bowel), surrounding the urethra (the tube carrying urine out of the bladder). The prostate has two main functions: producing and storing fluid that helps make semen and regulating bladder control.
What Happens If You Are Diagnosed With Prostate Cancer?
A diagnosis with prostate cancer does not mean that a person’s life has come to a full stop. Many people with prostate cancer, if diagnosed early, go on to live for many years. If the disease is diagnosed in very early stages, the doctor may only keep the patient under surveillance and treat as required. However, the patient must make some changes in their life during and after the treatment.
How Is Prostate Cancer Screening Done?
There are no standard or routine screening tests for prostate cancer. Studies are being done to find ways to make prostate-specific antigen (PSA) testing more accurate for early cancer detection.
The Early Signs of Prostate Cancer
Prostate cancer in its early stages usually causes no signs and symptoms. Screening can help detect the cancer early.
What Is the Most Used Treatment of Prostate Cancer?
Radiation therapy is the most used treatment of prostate cancer irrespective of the stage, current prostate-specific antigen (PSA) levels, prognosis, or risk rating.
Treatment & Diagnosis
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Medications & Supplements
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.