- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: yohimbine
Brand Names: Aphrodyne, Yocon
Drug Class: Herbals
What is yohimbine, and what is it used for?
Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions or psychological origin. There are, however, limited data on its efficacy, and more effective drugs such as phosphodiesterase-5 inhibitors are available to treat erectile dysfunction.
Yohimbine is a plant alkaloid isolated from the bark of Pausinystalia yohimbine, an evergreen tree native to central and western Africa. Yohimbine hydrochloride is a standardized form of yohimbine and is available as a prescription drug in the U.S.
Yohimbe is the P. yohimbine bark extract and is used in many herbal supplements sold over the counter. There is very little research on the safety and efficacy of yohimbe as a dietary supplement and currently, yohimbine is banned in many countries.
Yohimbine works by blocking alpha-2 adrenergic receptors, protein molecules on nerve cells that are stimulated by norepinephrine. This reduces sympathetic nervous system activity (adrenergic) and increases parasympathetic activity (cholinergic), resulting in increased blood flow into the penis and reduced outflow of blood, which help maintain erection.
- Do not use yohimbine in the following conditions:
- Yohimbine should not be used by women and children.
- Do not take yohimbine concurrently with foods rich in the amino acid tyramine, such as liver, cheese and red wine.
- Do not use yohimbine concurrently with other stimulant-like substances such as caffeine and ephedrine alkaloids. There have been reports of kidney failure, seizures, and death due to such combinations in dietary supplements.
What are the side effects of yohimbine?
Common side effects of yohimbine include:
- Worsening of panic attacks
- Seizure (with high doses)
- Increase in blood pressure
- Rapid heart rate (tachycardia)
- Prolonged or painful erection (priapism)
- Hypersensitivity reactions
- Reduced urine output
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of yohimbine?
- 5.4 mg
- 0.5-1 tablet/caplet three times daily
The suggested treatment period is no more than 10 weeks.
- Safety and efficacy not established
What drugs interact with yohimbine?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of yohimbine include:
- selegiline transdermal
- Yohimbine has serious interactions with at least 30 different drugs.
- Yohimbine has moderate interactions with at least 168 different drugs.
- Mild interactions of yohimbine include:
- American ginseng
- yerba mate
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
What else should I know about yohimbine?
- Take yohimbine in the standardized form of tablets, only if prescribed by your physician and exactly as instructed.
- Store safely out of reach of children.
- Avoid taking yohimbine/yohimbe extract that is available as herbal supplement, natural products are not necessarily safe.
- Herbal supplements do not undergo rigorous evaluation by the FDA for safety and efficacy. There may very often be discrepancy between the labeling and the actual yohimbine content in herbal supplements. A study that analyzed 49 supplements with yohimbine found that only three of them contained the amount of yohimbine advertised on the label.
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Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions or psychological origin. Yohimbine has also been used as a street drug, promoted as an aphrodisiac, hallucinogen, and for weight loss with little scientific evidence Yohimbine is a prescription medicine used to treat male impotence (erectile dysfunction) due to diabetes, vascular conditions, or psychological origin. Yohimbine should not be used by women and children. Yohimbine is not for use in women and pregnant or nursing women certainly should not take it.
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You can strengthen a weak prostate by eating healthy, staying active, maintaining a healthy weight, managing stress, and getting enough sleep.
The Early Signs of Prostate Cancer
Prostate cancer in its early stages usually causes no signs and symptoms. Screening can help detect the cancer early.
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A diagnosis with prostate cancer does not mean that a person’s life has come to a full stop. Many people with prostate cancer, if diagnosed early, go on to live for many years. If the disease is diagnosed in very early stages, the doctor may only keep the patient under surveillance and treat as required. However, the patient must make some changes in their life during and after the treatment.
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There are no standard or routine screening tests for prostate cancer. Studies are being done to find ways to make prostate-specific antigen (PSA) testing more accurate for early cancer detection.
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