What Level of Viral Load Is Undetectable?

The viral load test determines the level of the human immunodeficiency virus (HIV) in your blood. It is the recommended method of determining whether antiretroviral treatment is effective. The test counts the number of copies of HIV in 1 mL of blood.

Viral load test results assist your healthcare professional in tracking the progression of your infection, determining if your HIV therapy is effective, and making treatment decisions.

Keeping your viral load low will help your immune system stay healthy, reduce the likelihood of problems such as opportunistic infections, and help you live longer. If you stick to your treatment plan, you may be able to live a productive and healthy life.

Human immunodeficiency virus (HIV) viral load assays check for ribonucleic acid (RNA), the portion of HIV that contains the instructions for replication. To create extra copies of the RNA, the tests include an enzyme, which is a type of protein. This makes determining the amount of HIV in your blood sample easier.

These reverse transcription-polymerase chain reaction techniques are far more sensitive than previous HIV testing. In a milliliter of blood, they can discover as few as 20 copies of HIV RNA.

Because tests made by various manufacturers may produce slightly varied results, your healthcare professional must use the same HIV viral load test each time. Fluctuations in the viral load should be due to ongoing changes in your body but not because of a different testing procedure. New tests and more sensitive methods for detecting viral load are being developed by scientists.

A viral load tests count the number of human immunodeficiency virus (HIV) copies per milliliter of blood. Based on the number of copies, the tests are categorized into three types.

1. High HIV viral load:
   • A high HIV viral load is commonly defined as more than 100,000 copies per milliliter of blood; however, it might be one million or more.
   • The virus is replicating itself, and the sickness might spread swiftly.
2. Lower HIV viral load:
   • A lower HIV viral load is defined as less than 10,000 copies per milliliter of blood.
   • The virus is presumably not actively multiplying as quickly, and immune system harm may be reduced, but this is not ideal.
3. Undetectable HIV viral load:
   • An undetectable HIV viral load is defined as less than 20 copies per milliliter of blood.
   • Your viral load result may occasionally shift from undetectable to a low level (usually fewer than 400 copies/mL) and then back to undetectable. These blips are commonly seen even if you are being effectively treated for HIV. These blips do not indicate treatment failure or the development of resistance by the virus.

A viral load test is a blood test; therefore, it can detect only the virus present in your blood. 

• Your blood contains only 2 percent of the total human immunodeficiency virus (HIV) virus in your body.
• The remaining viral load is present in bodily tissues such as the lymph nodes, spleen, or brain, which cannot be detected through viral load tests.
• HIV levels in lymph tissue and sperm decrease as blood levels decrease, although not at the same time or rate.