What is the sentinel lymph node in breast cancer?
Breast cancer can spread to other parts of the body. It first reaches the lymph nodes in the armpit (axilla) close to the breast. Lymph nodes drain a liquid called lymphatic fluid from the breast and arm. The first nodes in the axilla affected by breast cancer are known as sentinel or guardian lymph nodes. If the doctor suspects that cancer has spread to sentinel lymph nodes or adjacent nodes, the physician may recommend a sentinel lymph node biopsy.
A positive sentinel lymph node biopsy or SLNB indicates that the cancer is no longer in situ. Cancer has spread to the sentinel lymph nodes and probably to other nearby lymph nodes. Thus, SLNB helps the physician to determine the exact stage of cancer that would help them to develop a treatment plan.
If the SLNB shows cancerous cells in three or more sentinel lymph nodes, the physician may recommend axillary dissection. There are three levels of axillary lymph nodes, which correspond to options for dissection:
- Level I: This refers to removing all tissue below the axillary vein and extending to the side where the axillary vein crosses the tendon of a muscle called the latissimus dorsi.
- Level II: This includes removing lymph nodes present under the chest wall muscles called the pectoralis minor.
- Level III: This includes complete removal of nodes present above the pectoralis minor muscle.
Axillary dissection is a surgical procedure that involves opening the axilla to identify, examine or remove the lymph nodes. It has been the standard technique used for the treatment of breast cancer affecting the axilla.
How is sentinel lymph node biopsy performed?
SLNB has two parts
- Lymphatic mapping
- Surgical procedure
Lymphatic mapping or lymphoscintigram involves injecting radioactive dye into the skin around the site of the tumor. Next, the physician uses a special camera to locate the radioactive material because it travels from the original tumor site to the sentinel lymph nodes.
After completing the lymphatic mapping, the physician injects a second blue dye to visualize the lymph nodes, which are already located by the specialized camera. The physician removes the sentinel lymph nodes and sends them for examination.
The surgical biopsy procedure includes a wide local excision, where the physician removes the tumor along with the biopsy tissue and some normal tissue surrounding it.
After examination of the biopsied tissue, the sentinel lymph node may show evidence of a cancerous tumor. If sentinel lymph nodes don’t show any cancer, it is improbable that cancer has spread to the remaining lymph nodes and no further surgery is needed.
The complications of SLNB include
How is axillary dissection performed?
The axillary dissection is performed simultaneously during a mastectomy surgery and is usually carried out under general anesthesia. The surgeon makes an incision under the arm and removes 10 to 40 lymph nodes from level I and II. Usually, the surgeon does not remove level III axial lymph nodes. However, the formation of lumps or larger nodes may force the surgeon to remove the level III lymph nodes as well. Finally, the surgeon places a small tube in the area and closes the incision with stitches or staples. A drainage bag attached to the end of the tube helps collect fluid discharge.
Some of the complications and side effects of the surgery include
- Signs of infection, such as pain, redness or pus
- Discomfort and soreness around the wound site
- Hematoma (pooling of blood)
- Swelling and bruising over the breast or axilla
- Seroma (fluid accumulation under the skin in the armpit)
- Shoulder stiffness
- Lymphedema (swelling of one of the arms or legs)
- Numb patch on the upper arm
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Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
What you should know about breast cancer
- Breast cancer is the most common cancer among American women.
- One in every eight women in the United States develops breast cancer.
- There are many types of breast cancer that differ in their capability of spreading (metastasize) to other body tissues.
- The causes of breast cancer are unknown, although medical professionals have identified a number of risk factors.
- There are many different types of breast cancer.
- Breast cancer symptoms and signs include
- a lump in the breast or armpit,
- bloody nipple discharge,
- inverted nipple,
- orange-peel texture or dimpling of the breast's skin (peau d'orange),
- breast pain or sore nipple,
- swollen lymph nodes in the neck or armpit, and
- a change in the size or shape of the breast or nipple.
- Breast cancer can also be symptom free, which makes following national screening recommendations an important practice.
- Breast cancer is diagnosed during a physical exam, by a self-exam of the breasts, mammography, ultrasound testing, and biopsy.
- Treatment of breast cancer depends on the type of cancer and its stage (0-IV) and may involve surgery, radiation, or chemotherapy.
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Breast Cancer Facts
Breast cancer is the most common non-skin cancer of American women, but it can also occur in men. Every year in the U.S., there are over 266,000 new diagnoses of breast cancer. A woman has a risk of one in eight for developing breast cancer at some point during her lifetime.
Breast Cancer TreatmentBreast cancer treatments depend upon the type of breast cancer that is present as well as the stage (extent of spread) of the tumor. Treatment for early breast cancer typically involves surgery to remove the tumor. After surgery, medical professionals may administer radiation therapy, chemotherapy, or targeted therapy.
Inflammatory Breast CancerInflammatory breast cancer is an accelerated form of breast cancer that is not usually detected by mammogram or ultrasound. Symptoms of inflammatory breast cancer include pain in the breast, skin change in the breast area, bruise on the breast,sudden swelling of the breast, nipple retraction or discharge, and swelling of the lymph nodes.
Male Breast CancerMale breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's risk of developing breast cancer is one in 1,000. Signs and symptoms include a firm mass located below the nipple and skin changes around the nipple, including puckering, redness or scaling, retraction and ulceration of the nipple. Treatment depends upon staging and the health of the patient.
Sentinel Lymph Node BiopsyThe sentinel lymph node is the first lymph node that receives lymphatic drainage from a tumor. Sentinel lymph node biopsy helps determine whether or not a cancerous tumor has spread. If cancer cells are detected in the sentinel lymph node, more lymph nodes may be removed. If no cancerous cells are detected, it is not necessary to remove additional lymph nodes.
Should I Have A Sentinel Node Biopsy?The first lymph nodes that drain lymph fluid from the primary tumor are called sentinel lymph nodes. Experts suggest that if the sentinel nodes do not show any cancer cells, the other nodes will also be devoid of cancer. This means that there may not be a need to remove the lymph nodes in the region where the cancer is present. Thus, knowing the status of sentinel lymph nodes is crucial in the management of cancers.
Triple-Negative Breast CancerTriple-negative breast cancer is more common in Hispanic and African-American women. Signs and symptoms include a lump in the armpit or breast, nipple discharge and inversion, and changes in the breast's skin. Treatment may incorporate surgery, chemotherapy, and radiation therapy.
What Is Usually the First Sign of Breast Cancer?A lump in the breast or in the armpits is often the first sign of breast cancer. This may be felt while in the shower. There may or may not be changes in the structure of the breast. Other early signs include changes in breast skin, breast pain and others.