what is the first sign of Huntington's disease
The first signs of Huntington's disease often appear when people are in their 30s or 40s and may include clumsiness, stumbling, or difficulty focusing

Symptoms of Huntington's disease often first appear when people are in their 30s or 40s. Initial signs may include clumsiness, stumbling, or difficulty focusing. Over 10-25 years, the disease gradually kills nerve cells in the brain.

Early stage symptoms

  • Difficulty learning new skills or things
  • Mood swings
  • Slow or abnormal eye movements
  • Muscle problems such as dystonia
  • Difficulty sleeping
  • Fatigue and tiredness
  • Memory lapses
  • Difficulty making decisions

Middle stage symptoms

Late stage symptoms

  • Dependency on others for self-care
  • Fidgety movements that have become severe or receding
Huntington's disease illustration

What Are the 5 Stages of Huntington’s Disease?

Huntington’s disease (HD) is a hereditary, progressive brain disorder characterized by uncontrolled movements, mental instability, and loss of thinking ability.

There is no cure for HD and no way to stop it from worsening. It is an autosomal dominant disease, which means that if one parent has the disease, there is a 50% chance that the child will have it.

The disease goes on to progresses over several years and can be divided into five stages.

  • Stage 1: Preclinical stage
  • Stage 2: Early stage
  • Stage 3: Middle stage
  • Stage 4: Late stage
  • Stage 5: End-of-life stage

What are symptoms of juvenile Huntington's disease?

If symptoms begin before age 20, it is known as juvenile Huntington's disease. Signs and symptoms of juvenile Huntington's disease include:

  • Stiffness or difficulty walking
  • Change in speech
  • Rigidity
  • Tremors
  • Seizures
  • Clumsiness
  • Behavioral problems
  • The sudden decrease in performance in school

What causes Huntington's disease?

Huntington's disease is a rare, hereditary disease that causes progressive degeneration of nerve cells of the brain, which can lead to emotional disturbances, memory problems, and uncontrolled movements.

  • If either of your parents has the disease, there is a 50% chance that you may develop it. This disease does not skip a generation, meaning that if you do not develop symptoms of Huntington's disease, you will not pass it to your children. 
  • About 1%-3%of of cases so far are found without a significant family history.

How is Huntington's disease diagnosed?

Family history is a major clue for diagnosis. Your doctor may recommend genetic testing to find a defective gene. They may perform detailed physical and neurological examinations that include checking the following:

  • Reflexes
  • Muscle strength
  • Sense of touch, vision, and hearing
  • Mood and mental state
  • Memory and reasoning
  • Behavioral patterns
  • Coping skills
  • Thinking skills

Doctors also perform imaging tests such as magnetic resonance imaging (MRI) and computed tomography (CT) scans to observe changes in areas of the brain affected by Huntington's disease.


The abbreviated term ADHD denotes the condition commonly known as: See Answer

How is Huntington's disease treated?

There is no permanent cure for Huntington's disease. However, medications can help control symptoms of movements and psychiatric disorders.

Drug therapy

Other therapies

Therapies directed at problematic areas include:

  • Speech therapy
  • Physical therapy
  • Occupational therapy
  • Psychiatric therapy

Home remedies

Lifestyle changes can help, including:

  • Exercising regularly
  • Eating healthy
  • Drinking plenty of water
  • Being socially active

Health Solutions From Our Sponsors

Medically Reviewed on 10/5/2021
Huntington's disease. https://emedicine.medscape.com/article/1150165-overview.

Huntington's Disease. https://my.clevelandclinic.org/health/diseases/14369-huntingtons-disease