Are you one of those who cannot shed extra pounds despite diet and exercise? Is your weight causing back pain and joint aches or worse? In these cases, your doctor may recommend a prescription weight loss drug in addition to (and not instead of) proper exercise and a balanced diet.
Many weight loss pills are available in the market. These are U.S. Food and Drug Administration (FDA)-approved for use more than 12 weeks. The best prescription pill for you depends on your weight loss goals, your tolerability to the pill prescribed and your coexisting health conditions, if any.
The most common weight loss medications tend to be appetite suppressants. Others interfere with the body’s fat absorption. What works for you might not work as well for others. Weight loss drugs can work by following methods.
- Decrease food intake (appetite suppressants)
- Increase feeling of fullness
- Both the above
- Alter the metabolism of food
Four weight loss drugs have been approved by the FDA for long-term use.
- Xenical (orlistat)
- Contrave (bupropion-naltrexone)
- Saxenda (liraglutide)
- Qsymia (phentermine-topiramate)
These may be used as a single agent or in combination with another medicine to reduce the adverse events or abuse potential. Belviq (lorcaserin) is another weight loss drug. As of February 2021, the FDA has requested the manufacturer to voluntarily withdraw the drug from the US market because of evidence reporting an increased cancer risk in the clinical trial.
How do these pills work?
Drugs that reduce food intake:
- Doctors usually prescribe the most common sympathomimetic drug called phentermine resin (phenyl-tertiary-butylamine), sold under the brand name Lonamin among others. Lonamin is the medication used together with diet and exercise to treat obesity.
- Sympathomimetic agents suppress appetite and induce satiety (feeling of fullness).
- These agents work by mimicking a neurotransmitter in the brain related to appetite called noradrenaline (NA).
- They also increase NA activity in the hypothalamus (the feeding center of the brain).
- NA binding and activity in the hypothalamus have a negative effect on appetite.
- Qsymia is a combination of two medications, namely, phentermine and topiramate. Phentermine reduces appetite and topiramate is used to treat seizures and migraines.
- Qsymia is prescribed to help adults who are overweight or obese with weight-related medical problems lose weight and keep it off.
- Qsymia helps curb hunger and makes people feel full sooner, allowing them to eat less.
- Because Qsymia may lead to birth defects, women who are pregnant or planning to become pregnant should not take Qsymia. Women should avoid Qsymia if they are breastfeeding or if they have glaucoma or hyperthyroidism.
Drugs that alter the metabolism of food
- It is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical.
- It prevents approximately 30 percent of dietary fat from meals being absorbed into the body.
- Along with decreasing the absorption of dietary triglycerides, orlistat has been found to
Gastrointestinal adverse effects of orlistat act similar to negative reinforcement, encouraging those on the medication to adhere to a low-fat diet.
Drugs that increase fullness or satiety
- It is a combination of two generic drugs, namely, bupropion and naltrexone. Bupropion is an antidepressant and naltrexone is used for drug addiction.
- Contrave acts on the brain to reduce appetite and the desire to comfort eat.
- People on the medication start by taking one tablet each morning and gradually work their way up to taking two tablets twice a day. The slow increase in dosage allows the body to adjust to the medication.
- Contrave leads to greater weight loss than diet or exercise alone. According to a study, people taking Contrave lost 5.4 percent of their body weight on average.
- However, common side effects may be seen. Hence, people should take it under their doctor’s supervision.
- People should not take Contrave if they have a seizure disorder, uncontrolled high blood pressure or narcotic addiction (or if they are on medication to treat such an addiction).
- Saxenda, a brand name for the medication liraglutide, is a prescription weight loss injection that’s self-administered once daily. When combined with a low-calorie diet and increased physical activity, it can help adults with obesity as well as those who have a body mass index (BMI) of 27 or higher and a weight-related medical condition to lose weight and keep it off.
- Saxenda mimics the satiety hormone, helping control appetite and reduce eating.
- Apart from common side effects such as nausea, Saxenda’s more serious but less common side effects include thyroid tumors (including cancer), gallbladder problems (including gallstones), kidney failure and inflammation of the pancreas.
The best treatment for a patient depends on their weight, health, risk factors and lifestyle. Some people find it difficult to adhere to the necessary lifestyle and dietary changes whereas others simply may not respond to the medication. Everyone using weight loss medication must be assessed by their doctor within six weeks to three months of starting the treatment to determine whether it is working effectively.
Health Solutions From Our Sponsors
Duke Global Health Institute
Top What Is the Best Prescription Weight Loss Pill Related Articles
amoxicillinAmoxicillin is an antibiotic that belongs to a class of antibiotics called penicillins. Common infections that amoxicillin is used to treat include middle ear infections, tonsillitis, laryngitis, bronchitis, pneumonia, skin, gonorrhea, and urinary tract infections. Common side effects of amoxicillin include nausea, itching, vomiting, confusion, abdominal pain, and easy bruising. Amoxicillin is generally considered safe to use while pregnant or breastfeeding.
Can You Lose Belly Fat by Drinking Water?Drinking water is an important part of staying healthy. Staying hydrated is critical if you’re trying to lose weight because it helps your body function effectively and will help you feel better overall.
Diet Pills, Weight Loss Drugs, SuppressantsMaintaining a healthy weight is important because being overweight or underweight may lead to various health issues. Body mass index or BMI is calculated by dividing a person’s weight in kilograms by the square of their height in meters.
Diet and Weight Loss: Reasons You're Not Losing Belly FatIf you're trying to lose belly fat but can't, there's probably a reason.
Do People Get Jealous of Your Weight Loss?You are so thrilled with your weight loss, and you might naturally expect that your friends and family will be equally happy. When you lose weight, you can trigger jealousy in others for a variety of reasons.
How to Lose Weight Fast: Easy Weight Loss TipsHere are the best ways to lose weight. From calories to fitness, learn these weight loss tips and win your battle with losing weight.
Weight Loss Pills and Supplements: Do They Work?A bodyweight over the healthy limit is associated with several health conditions, such as diabetes, heart diseases, and certain cancers. According to health experts, long-term weight loss can be safely attained by making healthy lifestyle changes like healthy eating patterns, limiting calorie intake, and doing regular physical activity. Many people, however, are not able to make these healthy lifestyle changes.
What Are the Most Effective Tips in Weight Loss?If you want to lose weight, you may have been told to count calories. The most effective tips for weight loss include eating well, exercising regularly, and altering your lifestyle to achieve your goals.
What Are the Top 10 Most Prescribed Drugs?The top 10 most prescribed drugs are atorvastatin, levothyroxine, lisinopril, metformin, metoprolol, amlodipine, albuterol, omeprazole, losartan, and gabapentin.
Which Hormones Help You Lose Weight?Some major hormones in the body like thyroid, estrogen, and testosterone are associated with weight gain or loss. If you are able to correct hormonal imbalances, you may see a significant reduction in your body weight.
Why Do Guys Lose Weight So Fast?Men tend to lose weight faster than women. The reason that men lose weight faster than women includes that women are hormonally wired to store more fat; men and women store fat differently; menstruation triggers stress eating; men lose more water weight than women; men have more muscle than women and other factors.