Paradoxical adipose hyperplasia is a rare side effect of the cosmetic procedure called cryolipolysis.
It is called so because the cryolipolysis procedure is expected to reduce the fatty or adipose tissue deposits, which are paradoxically increased (hyperplasia) in this side effect.
The symptoms of paradoxical adipose hyperplasia may appear a few days to weeks after cryolipolysis.
- The treated area feels thicker and firmer.
- A mass or swelling may be felt under the skin and is often slightly painful to touch.
- It may gradually increase in size although the severity of hyperplasia may vary from moderate to severe.
- The treated area may develop hard lumps due to unequal fat distribution under the skin.
What is cryolipolysis?
Cryolipolysis, popularly called CoolSculpting, is a popular cosmetic procedure that uses very cold temperatures to destroy fat cells. It is a minimally invasive procedure requiring no sedation and is generally done in outpatient settings to safely remove stubborn fat deposits without any downtime.
Millions of cryosculpting procedures are performed globally and most have minimal side effects, such as:
- numbness, or
- darkening of the treated area.
Most of these side effects completely resolve in a few months.
A rare, but serious, side effect of this procedure is paradoxical adipose hyperplasia that increases the number of fat cells in the treated area.
Is paradoxical adipose hyperplasia cancerous?
No, paradoxical adipose hyperplasia is a benign (noncancerous) condition. It may, however, cause significant disfigurement. Thus, the affected person may have considerable emotional stress due to this side effect.
What are the risk factors of paradoxical adipose hyperplasia after cryolipolysis?
Paradoxical adipose hyperplasia is a rare side effect seen in less than one percent of the patients undergoing cryolipolysis. The definitive causes and risk factors of paradoxical adipose hyperplasia are not well understood.
Some of the potential risk factors of this condition include:
- Male gender (males are about three times more likely to be affected than females)
- Genetic predisposition
- Use of a large handpiece during the procedure
- A cryolipolysis procedure done in the past
- Hispanic or Latino origin
- Cryolipolysis done on the abdominal region
Can paradoxical adipose hyperplasia be reversed?
Paradoxical adipose hyperplasia does not go away on its own. Most affected people require corrective surgeries, such as excision or corrective liposuction. Because these procedures are invasive, many people do not appreciate them, since most people chose cryolipolysis in the first place because of its noninvasive nature.
An abdominoplasty or tummy tuck procedure may be needed along with liposuction surgery in some people with paradoxical adipose hyperplasia affecting the abdomen. Repeated surgeries may be needed in severe cases.
Some people may choose to undergo the additional laser lipolysis or a repeat cryolipolysis procedure, but the results may not be satisfactory. Often, the corrective surgery is delayed for a few months after cryolipolysis to allow the treated area to soften.
IMAGESBrowse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies See Images
Nikolis A, Enright KM. A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8658 Cycles in 2114 Patients. Aesthet Surg J. 2021 Jul 14;41(8):932-941. https://pubmed.ncbi.nlm.nih.gov/33216910/
Kelly ME, Rodríguez-Feliz J, Torres C, Kelly E. Treatment of Paradoxical Adipose Hyperplasia following Cryolipolysis: A Single-Center Experience. Plast Reconstr Surg. 2018 Jul;142(1):17e-22e. https://pubmed.ncbi.nlm.nih.gov/29952891
American Society of Plastic Surgeons. Nonsurgical Fat Reduction. https://www.plasticsurgery.org/cosmetic-procedures/nonsurgical-fat-reduction/cryolipolysis
Top What Is Paradoxical Adipose Hyperplasia Related Articles
Can a Tummy Tuck Cause Stomach Issues?Stomach cramps are the most common side effect after the tummy tuck procedure. Abdominoplasty or tummy tuck is a cosmetic procedure to remove excess skin and fat from the abdomen or tummy. Scarring, pain, swelling and other issues may occur after a tummy tuck.
Diet Pills, Weight Loss Drugs, SuppressantsMaintaining a healthy weight is important because being overweight or underweight may lead to various health issues. Body mass index or BMI is calculated by dividing a person’s weight in kilograms by the square of their height in meters.
Diet & Weight Loss: Reasons You're Not Losing Belly FatIf you're trying to lose belly fat but can't, there's probably a reason.
Does Coolsculpting Really Work?CoolSculpting (medical term: cryolipolysis) is also called fat-freezing. This technique uses extremely low temperatures to break fat cells down in the body. It is one of the most popular techniques for nonsurgical fat reduction. Around 4,50,000 CoolSculpting procedures have been performed all over the world. The origin of CoolSculpting (destroying fat cells by freezing) has an interesting story behind it.
Fitness and Exercise: Best Exercises for Weight LossIf you’re trying to lose weight, some exercises might be better than others. Check out these 11 choices you can put in your workout routine.
How Long Do CoolSculpting Results Last?Cool sculpting treatments actually kill fat cells, hence results may last indefinitely. To maintain long-term results, the individual may need to adhere to a healthy diet and regular exercise. Once fat cells are removed, they can’t migrate or re-grow. After cool sculpting treatment, results will begin to develop a few weeks after the procedure.
Is Abdominoplasty Safe?Abdominoplasty (tummy tuck) is a procedure to correct abdominal deformity due to excess skin, subcutaneous tissue and laxity of the abdominal wall musculature. Abdominoplasty is one of the most performed cosmetic surgical procedures and the procedure is usually performed by a plastic surgeon.
Is Coolsculpting Permanent?Cool sculpting or cryolipolysis is a nonsurgical or noninvasive method for body contouring. The procedure involves the use of cold temperature to kill fat cells present under the skin (subcutaneous fat). Since the fat cells are killed, the results are technically permanent.
Diet and Weight Loss: Morning Habits to Help You Lose WeightYour morning habits can help you lose weight. Learn tips for healthy eating, better sleep, and mind/body wellness.
Obesity and OverweightGet the facts on obesity and being overweight, including the health risks, causes, reviews of weight-loss diet plans, BMI chart, symptoms, causes, surgical and nonsurgical treatments, and medications.
Skin RashThe word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different skin conditions. The most common of these are scaly patches of skin and red, itchy bumps or patches all over the place.
Sebaceous HyperplasiaSebaceous hyperplasia is a skin condition that becomes more common with age. It's caused when your sebaceous oil glands produce too much oil, which can be trapped under your skin and cause bumps. The good news is, there are many treatment options available for sebaceous hyperplasia.
The 10 Best Diet Plans For Weight LossDiet means a reduction in calorie intake. For the optimal management of overweight and obese patients, a combination of diet, exercise, and behavioral modifications may be helpful. Weight loss is directly related to the difference between the individual’s energy intake and energy expenditure.
Weight Loss Pills and Supplements: Do They Work?A bodyweight over the healthy limit is associated with several health conditions, such as diabetes, heart diseases, and certain cancers. According to health experts, long-term weight loss can be safely attained by making healthy lifestyle changes like healthy eating patterns, limiting calorie intake, and doing regular physical activity. Many people, however, are not able to make these healthy lifestyle changes.
Weight Loss QuizAre you trying to lose weight? Take this quiz to see what you can add to routine to get on the right track for results!
Weight Loss Surgery QuizWhat happens after weight loss surgery? What should you eat? Take this quiz to learn about bariatric surgery. Are you a candidate?