What Is Mononeuritis Multiplex?

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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What is mononeuritis multiplex?

Doctor's response

Mononeuritis multiplex is inflammation of two or more nerves, typically in unrelated portions of the body.

Mononeuritis multiplex causes a loss of function of the muscle tissue that is innervated by the affected nerve. For example, sudden loss of ability to normally lift the foot up while walking (foot drop) can be caused by mononeuritis multiplex when accompanied by loss of nerve function elsewhere in the body.

There are many causes of mononeuritis multiplex including diabetes mellitus, infections (such as AIDS, Lyme disease, and leprosy), sarcoidosis, and connective tissues diseases (such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis, Churg-Strauss syndrome, cryoglobulinemia, Sjogren's syndrome.

The treatment of mononeuritis multiplex depends on the underlying cause.

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Reviewed on 1/11/2018