The FDA has issued an emergency use authorization (EUA) for monoclonal antibodies (mAbs) for the treatment of COVID-19 under specific conditions.
Antibodies are proteins produced by a type of immune cells (B cells) in the body that attack harmful cells in response to infection. The site on the pathogen to which the antibody binds is called an antigen epitope.
Monoclonal antibodies for COVID-19 are lab-produced antibodies that can prevent the SARS-CoV-2 virus from attaching to cells. They are produced from a single clone of B cells and target the same antigen epitope on the virus. mAbs against SARS-CoV-2 are called anti-SARS-CoV-2 mAbs. They have specific epitopes on the spike protein present on the surface of the coronavirus, which play a crucial role in allowing the entry of the virus into the host cell and thus causing COVID-19.
The FDA has issued EUA to four types of mAb treatments for the treatment of SARS-CoV-2 infection:
- Bamlanivimab plus etesevimab
- Casirivimab plus imdevimab
Who is eligible for monoclonal antibodies for COVID-19?
Anti-SARS-CoV-2 monoclonal antibodies (mAbs) may be used for the treatment of mild to moderate COVID-19 in adults and children (at least 12 years or older and weighing at least 88 lbs) with positive results of direct SARS-CoV-2 viral testing and who are at a high risk of progressing to severe COVID-19. The minimum body mass index for receiving anti-SARS-CoV-2 mAbs is 25.
Conditions that may act as high risk factors for progression to the severe disease include:
- Age 65 or older
- Chronic diseases such as chronic kidney disease, diabetes, cardiovascular diseases, and chronic lung diseases
- Obesity or being overweight
- Immunocompromised individuals
- Neurodevelopmental disorders (such as cerebral palsy)
- Genetic or metabolic syndrome
- Severe congenital anomalies
- Medical-related technological dependence (such as gastrostomy, tracheostomy, or positive pressure ventilation not related to COVID-19)
mAbs can be used in both non-hospitalized people and people hospitalized due to a reason other than COVID-19, provided that they have mild to moderate COVID-19. Anti-SARS-CoV-2 mAbs cannot be given if the affected person:
- Is hospitalized for COVID-19
- Requires oxygen therapy due to COVID-19
- Is on chronic oxygen therapy due to underlying non-COVID-19-related comorbidity and requires an increase in oxygen flow rate from the baseline because of COVID-19
Anti-SARS-CoV-2 mAbs may be administered as a preventive therapy or postexposure prophylaxis for certain individuals, including people who are at high risk of SARS-CoV-2 infection and have a higher likelihood of progressing to serious illness if infected.
Can you get vaccinated against COVID-19 if you received monoclonal antibodies?
According to the CDC, people who have received anti-SARS-CoV-2 monoclonal antibodies (mAbs) must avoid vaccination against COVID-19 until at least 90 days have passed after the therapy is completed. This waiting period is a precautionary measure because anti-SARS-CoV-2 mAbs can interfere with the immune response generated by the body in response to the vaccine, rendering it less effective or ineffective.
If, however, a person vaccinated against COVID-19 gets the disease, they may be administered anti-SARS-CoV-2 mAbs regardless of the timing of vaccination. This may be done if there are no logistical or supply constraints limiting the availability of the authorized anti-SARS-CoV-2 mAbs.
Top What Is a Monoclonal Antibody for COVID-19 Related Articles
Can COVID-19 Vaccine Affect Fertility?The COVID-19 vaccine does not affect fertility.
Coronavirus COVID-19 Prevention: Test Your Medical IQWhat's really the best way to prevent the spread of new coronavirus COVID-19? Should wear a mask or not? Take this quiz to find out!
COVID-19 Coronavirus Disease: Articles of InterestRead about COVID-19 Coronavirus Disease. See interesting articles related to vitamins and supplements to boost immunity, symptoms, prevention, vaccines, historical comparisons to past pandemics, and more.
Coronavirus: How COVID-19 Affects Your BodyBy now, everyone knows about COVID-19. But do you know how it can affect your body?
What Are the Differences Between Moderna and Pfizer-BioNTech COVID-19 Vaccines?Despite being made using the same technology and sharing similar effects on the body, here are the differences between the Moderna and Pfizer-BioNTech COVID-19 vaccines.
Do Recovered COVID-19 Patients Have Antibodies?While antibodies have been found in people who recover from COVID-19, it’s unclear how long the immune response lasts. It’s important to continue following public health guidelines to protect yourself from reinfection.
How Do the COVID-19 Coronavirus Tests Work?Tests used for detection of SARS-CoV-2 (COVID-19) may use two methods to detect SARS-CoV-2 virus, the cause of COVID-19 disease, a debilitating and potentially deadly viral pneumonia. Genomic or molecular detection confirms the presence of viral DNA. The immunoglobulin or serology tests can tell whether or not you have been exposed to coronavirus, but not whether you are currently infected. Both tests administered in tandem can give you your complete COVID-19 infection status.
Is COVID-19 Life-Threatening?Most people infected with COVID-19 experience mild to moderate respiratory symptoms and recover without special medical treatment. However, the virus is much more life-threatening to older people and those with underlying medical problems.
Is Your Immune System Stronger After COVID-19?A robust immune system protects you from getting sick following exposure to germs and viruses. Yes, recovering from COVID-19 makes your immune system stronger.
Lung and Respiratory: Signs That You May Have Had COVID-19Could you have already had COVID-19 and not know it? Learn some signs that might indicate just that.
How to Differentiate Between the Signs and Symptoms of COVID-19, Allergies, Cold, and Flu?Coronavirus disease or COVID-19 is an infectious disease caused by a newly discovered coronavirus called SARS-CoV-2. Most people with COVID-19 will experience a mild to moderate respiratory illness and recover without the need for intensive or special treatment. Serious illness is more likely in elderly people and those with underlying medical conditions such as heart disease, diabetes, chronic respiratory disease, and cancer.
Tests Available for COVID-19Getting tested for COVID-19 can identify you as a positive or negative patient of the disease. Remember no test is 100% accurate. Different methods of testing have been launched to trace COVID-19 infection.
What Is the COVID-19 Antibody Test For?The COVID-19 antibody test, also known as a serology test, is a blood test that looks for antibodies to determine whether you have had a recent or past infection of the virus that causes COVID-19.
COVID-19 (Coronavirus, 2019-nCoV)Infection with COVID-19 (2019 novel coronavirus, 2019-nCoV) causes respiratory problems in humans. Transmission of COVID-19 occurs mainly through contact with respiratory sections from an infected person, however, fecal contamination may also spread the virus. Symptoms start off flu-like and progress to coughing, fever, shortness of breath, shaking chills, headache, loss of sense of taste and/or smell, muscle pain, and sore throat. Treatment focuses on supportive care and symptom relief. COVID-19 vaccines are available.
Coronavirus COVID-19 (SARS-CoV-2) Pandemic Outbreak: What You Need to KnowA new strain of coronavirus (COVID-19, SARS-CoV-2) was reported from Wuhan, China in December, 2019. This outbreak of respiratory flu-like symptoms has quickly spread resulting in a worldwide pandemic. Learn about symptoms, treatment, prevention and vaccine efforts.