Lifetime risk of getting cancer

The term cancer refers to the uncontrolled growth of cells in the body. There are trillions of cells in our body. Under normal circumstances, the cells grow and divide according to the body’s needs. When the cells become old or develop any abnormality, they die. Thus, the growth, division, and death of the cells occur under regulated conditions in the body. This ensures that body functions occur optimally while maintaining the structure of various tissues and organs in the body. When this regulation of cell growth, division, and death is disturbed, cancer begins. Thus, the abnormal or “cancerous” cell is no more under the control of the regulatory machinery, and it keeps dividing to produce more cells of its type. This leads to the crowding of cells at the affected site. The abnormal cells devour the nutrients and oxygen while depriving the normal cells of nutrients, oxygen, and even space. The abnormal cells invade nearby and distant sites (metastasis) hampering normal functioning wherever they go.
Cancer can affect almost any part of the body from the head to the toes and is named according to the site of origin. Cancer can be divided into two broad categories.
- Hematologic or blood cancer: It arises from any of the blood cells. Examples include lymphoma, leukemia, and multiple myeloma.
- Solid tumor cancer: It arises from the tissues and organs other than the blood cells. Examples include breast, prostate, lung, colorectal and ovarian cancer.
One in three people in the United States suffers from cancer. Cancer is the second leading cause of death worldwide. It affects around 1.8 million people each year in the United States. Moreover, it causes the second-highest number of deaths (after ischemic heart disease) in the United States. It was responsible for around 606,520 deaths in 2020.
The odds of having any type of cancer depend on the presence of several risk factors that make you more likely to have that cancer. These include factors such as
- Age
- Gender
- Personal or family history of cancer
- Exposure to any cancer-causing chemicals or ultraviolet (UV) rays
- A lifestyle that includes addictions (smoking and alcohol consumption)
Thus, the lifetime risk or odds of developing or dying from any type of cancer differ from person to person.
Lifetime risk of developing or dying from cancer
The risk of cancer or dying from it can be expressed in two ways: percentage and odds. Thus, if a man’s risk of dying from breast cancer in the United States is 0.03 percent, it means he has around 1 in 3,333 (100/0.03) chance of dying from breast cancer. In terms of odds, it means around 1 in 3,333 men in the United States will die from breast cancer.
The lifetime risks of developing and dying from certain cancers for men and women in the United States are given in the tables below. Data are taken from the National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) database. Risks are expressed as an average for the entire US population. Thus, your individual risk may vary depending upon the presence or absence of any risk factors.
Males
Risk of developing | Risk of dying from | |||
---|---|---|---|---|
% | 1 in | % | 1 in | |
All invasive sites | 40.2 | 2 | 20.5 | 5 |
Bladder (includes in situ) | 3.8 | 26 | 0.9 |
109 |
Brain and nervous system | 0.7 | 143 | 0.5 | 188 |
Breast | 0.1 | 727 | <0.1 | 3,260 |
Colon and rectum | 4.2 | 24 | 1.8 | 57 |
Esophagus | 0.8 | 126 | 0.7 | 137 |
Hodgkin lymphoma | 0.2 | 434 | <0.1 | 2,792 |
Kidney and renal pelvis | 2.2 | 46 | 0.6 | 175 |
Larynx (voice box) | 0.5 | 200 | 0.2 | 561 |
Leukemia | 1.9 | 54 | 0.9 | 107 |
Liver and bile duct | 1.5 | 69 | 1 | 97 |
Lung and bronchus | 6.4 | 16 | 5 | 20 |
Melanoma of the skin | 3.7 | 27 | 0.4 | 235 |
Multiple myeloma | 1.0 | 105 | 0.5 | 218 |
Non-Hodgkin lymphoma | 2.4 | 42 | 0.8 | 126 |
Oral cavity and pharynx | 1.7 | 60 | 0.4 | 239 |
Pancreas | 1.7 | 59 | 1.4 | 71 |
Prostate | 12.5 | 8 | 2.4 | 41 |
Stomach | 1.0 | 98 | 0.4 | 239 |
Testicles | 0.4 | 244 | <0.1 | 4,982 |
Thyroid | 0.7 | 149 | 0.1 | 1,699 |
Females
Risk of developing | Risk of dying from | |||
---|---|---|---|---|
% | 1 in | % | 1 in | |
All invasive sites | 38.5 | 3 | 17.9 | 6 |
Bladder (includes in situ) | 1.2 | 86 | 0.3 | 292 |
Brain and nervous system | 0.5 | 186 | 0.4 | 239 |
Breast | 12.9 | 8 | 2.5 | 39 |
Cervix | 0.6 | 159 | 0.2 | 461 |
Colon and rectum | 4.0 | 25 | 1.6 | 62 |
Esophagus | 0.2 | 433 | 0.2 | 513 |
Hodgkin lymphoma | 0.2 | 517 | 0 | 3.683 |
Kidney and renal pelvis | 1.3 | 79 | 0.3 | 311 |
Larynx (voice box) | 0.1 | 835 | 0 | 2,239 |
Leukemia | 1.3 | 77 | 0.7 | 150 |
Liver and bile duct | 0.6 | 157 | 0.5 | 182 |
Lung and bronchus | 6.0 | 17 | 4.2 | 24 |
Melanoma of the skin | 2.5 | 40 | 02 | 463 |
Multiple myeloma | 0.7 | 138 | 04 | 272 |
Non-Hodgkin lymphoma | 1.9 | 52 | 0.6 | 164 |
Oral cavity and pharynx | 0.7 | 140 | 0.2 | 536 |
Pancreas | 1.6 | 61 | 1.4 | 73 |
Ovary | 1.2 | 85 | 0.8 | 119 |
Stomach | 0.7 | 152 | 0.3 | 351 |
Testicles | 0.4 | 244 | <0.1 | 4,982 |
Thyroid | 1.8 | 55 | 0.1 | 1,413 |
Uterus | 3.1 | 32 | 0.7 | 154 |

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