What are the Long Term Effects of Omeprazole?

Last Editorial Review: 1/11/2018

Ask the experts

Since omeprazole inhibits acid production, how long can it safely be taken without upsetting the acid/alkaline balance? Can the 20mg. dosage be taken every other day rather than daily and have similar effects? For symptoms of indigestion, is two-week therapy adequate?

Doctor's response

Omeprazole controls acid production in the stomach only and does not affect the acid/alkaline balance of the body. The drug has been in use for some 10 years and appears to be safe for long term use. Omeprazole has not been studied when given every other day so it is not known if it is effective when given this way. Most of the diseases that Omeprazole is prescribed for (e.g., ulcers, esophagitis) take longer than two weeks to treat.


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