Vtama (tapinarof) cream, 1%

Vtama (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults. It is not known if Vtama cream is safe and effective in children with psoriasis under 18 years of age. The specific mechanisms by which Vtama cream exerts its therapeutic action in psoriasis patients are unknown. 

The most common side effects of Vtama cream include:

• red raised bumps around the hair pores (folliculitis)
• pain or swelling in the nose and throat (nasopharyngitis)
• skin rash or irritation, including itching and redness, peeling, burning, or stinging
• headache
• itching
• flu

Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:

• Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
• Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
• Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
• Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.

This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.

Vtama cream, 1%

Each gram of Vtama cream contains 10 mg of tapinarof in a white to off-white cream

• Apply a thin layer of Vtama cream only to your psoriasis skin lesions 1 time a day. Avoid applying Vtama cream to unaffected areas of your skin.
• Wash hands after application, unless Vtama cream is for treatment of the hands.
• If someone else applies Vtama cream for you, they should wash their hands after application.
• Vtama cream is not for oral, ophthalmic, or intravaginal use.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Vtama cream for a condition for which it was not prescribed. Do not give Vtama cream to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Vtama cream that is written for health professionals.

Currently, there is no data available on any potential drug interactions with Vtama.

Before using Vtama cream, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant. It is not known if Vtama cream will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if Vtama cream passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Vtama cream.

• Store Vtama cream at room temperature between 68°F to 77°F (20°C to 25°C).
• Do not freeze Vtama cream.
• Protect Vtama cream from exposure to excessive heat.
• Keep Vtama cream and all medicines out of the reach of children.