Vtama (tapinarof) cream, 1%

Medically Reviewed on 6/12/2023

Brand Name: Vtama cream

Generic Name: tapinarof

Drug Class: AHR Agonists

What is Vtama (tapinarof) cream, and what is it used for?

Vtama (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults. It is not known if Vtama cream is safe and effective in children with psoriasis under 18 years of age. The specific mechanisms by which Vtama cream exerts its therapeutic action in psoriasis patients are unknown. 

What are the side effects of Vtama?

The most common side effects of Vtama cream include:

Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:

This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.

What is the dosage for Vtama?

Vtama cream, 1%

Each gram of Vtama cream contains 10 mg of tapinarof in a white to off-white cream

  • Apply a thin layer of Vtama cream only to your psoriasis skin lesions 1 time a day. Avoid applying Vtama cream to unaffected areas of your skin.
  • Wash hands after application, unless Vtama cream is for treatment of the hands.
  • If someone else applies Vtama cream for you, they should wash their hands after application.
  • Vtama cream is not for oral, ophthalmic, or intravaginal use.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Vtama cream for a condition for which it was not prescribed. Do not give Vtama cream to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Vtama cream that is written for health professionals.

What drugs interact with Vtama?

Currently, there is no data available on any potential drug interactions with Vtama.

Pregnancy and breastfeeding

Before using Vtama cream, tell your healthcare provider about all of your medical conditions, including if you:

  • are pregnant or plan to become pregnant. It is not known if Vtama cream will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Vtama cream passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Vtama cream.

What else should I know about Vtama cream?

  • Store Vtama cream at room temperature between 68°F to 77°F (20°C to 25°C).
  • Do not freeze Vtama cream.
  • Protect Vtama cream from exposure to excessive heat.
  • Keep Vtama cream and all medicines out of the reach of children.


Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer


Vtama (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults. The most common side effects of Vtama cream include red raised bumps around the hair pores (folliculitis), pain or swelling in the nose and throat (nasopharyngitis), skin rash or irritation (itching, redness, peeling, burning, or stinging), headache, itching, and flu. Consult your doctor if pregnant or breastfeeding.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 6/12/2023
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