GENERIC NAME: VORICONAZOLE - ORAL SUSPENSION (vor-ih-CON-ah-zole)
BRAND NAME(S): Vfend
HOW TO USE: This medicine comes with a Patient Information Leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine.Shake the bottle well before taking each dose. Use the oral dispenser supplied with the medication to measure out each dose carefully.Take this medication by mouth on an empty stomach (at least 1 hour before or after a meal) usually twice daily, or as directed by your doctor. The dose and duration of treatment depend on your condition and response to therapy.Continue to take this medication until the full prescribed amount is finished. Stopping the medication too early may result in reinfection.Inform your doctor if your condition persists or worsens.
SIDE EFFECTS: Fever, chills, nausea, diarrhea, dizziness, flushing and headache may occur. If any of these effects persist or worsen, notify your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these serious side effects occur: vision changes (e.g., blurring, color vision changes), sensitivity of eyes to light (photophobia).Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, sun sensitivity, change in the amount of urine, easy bleeding or bruising, bone/muscle/joint pain.Seek immediate medical attention if any of these rare but very serious side effects occur: severe dizziness, fainting, fast/irregular heartbeat.This drug may rarely cause serious (possibly fatal) liver problems. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes or skin, dark urine, unusual fatigue, stomach/abdominal pain.A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking voriconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole-type antifungal drugs (e.g., itraconazole, ketoconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Tell your doctor your medical history, especially of: liver disease, heart problems (e.g., irregular heartbeats), recent chemotherapy, mineral/electrolyte imbalance (e.g., low blood levels of calcium).Voriconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using voriconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using voriconazole safely.This medication, especially when taken for long periods of time, may affect your vision. Your vision should be monitored closely while taking this medication. Report any loss of vision, problems recognizing colors correctly, or any other vision problems immediately to your doctor.This drug may make you dizzy or cause vision changes. Do not drive (especially at night), use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, use a sunscreen and wear protective clothing when outdoors.Before having surgery, tell your doctor or dentist that you are using this medication.This product contains sucrose and is therefore not recommended if you have a rare hereditary metabolic condition (e.g., fructose intolerance, sucrase-isomaltase deficiency, glucose-galactose malabsorption).Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).This medication is not recommended for use during pregnancy as it may cause harm to an unborn baby. Women should use a reliable form of birth control while taking this medication. Consult your doctor for more details.It is not known whether this drug passes into breast milk. Breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: ergot alkaloids (such as ergotamine, dihydroergotamine), sirolimus, a certain combination HIV medication (such as efavirenz/emtricitabine/tenofovir).Many drugs besides voriconazole may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include certain alpha blockers (such as alfuzosin, silodosin, tamsulosin), birth control pills, cisapride, dronedarone, eletriptan, eplerenone, lurasidone, ranolazine, certain "statin" drugs (such as lovastatin, simvastatin), ticagrelor, tolvaptan, among others.Other medications can affect the removal of voriconazole from your body, which may affect how voriconazole works. Examples include certain barbiturates (such as mephobarbital, phenobarbital), carbamazepine, enzalutamide, primidone, rifamycins (such as rifabutin, rifampin), ritonavir, St. John's wort, among others.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., liver, kidney, vision tests) may be performed to monitor your progress or check for side effects. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture. Do not refrigerate or freeze. Discard any unused portion after 14 days. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised January 2014. Copyright(c) 2014 First Databank, Inc.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.