- Side Effects
- Drug Interactions
What is Verquvo (vericiguat), and what is it used for?
Verquvo (vericiguat) is a prescription medicine used in adults who are having symptoms of their chronic (long-lasting) heart failure, who have had a recent hospitalization or the need to receive intravenous (IV) medicines and have an ejection fraction (amount of blood pumped with each heartbeat) of less than 45 percent:
- to reduce the risk of dying and
- to reduce the need to be hospitalized
What are the side effects of Verquvo?
Females of reproductive potential: Exclude pregnancy before the start of treatment. To prevent pregnancy, females of reproductive potential must use effective forms of contraception during treatment and for one month after stopping treatment. Do not administer Verquvo to a pregnant female because it may cause fetal harm.
The most common side effects of Verquvo include:
These are not all the possible side effects of Verquvo. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Verquvo?
- The recommended starting dose of Verquvo is 2.5 mg orally once daily with food.
- Double the dose of Verquvo approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient.
- For patients who are unable to swallow whole tablets, Verquvo may be crushed and mixed with water immediately before administration.
Pregnancy Testing In Females Of Reproductive Potential
- Obtain a pregnancy test in females of reproductive potential prior to initiating treatment with Verquvo.
What drugs interact with Verquvo?
Other Soluble Guanylate Cyclase Stimulators
- Verquvo is contraindicated in patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators.
- Concomitant use of Verquvo with PDE-5 inhibitors is not recommended because of the potential for hypotension.
Verquvo contraindications, and pregnancy and breastfeeding safety
Verquvo may cause birth defects if taken during pregnancy.
- Females must not be pregnant when they start taking Verquvo.
- Females who are able to get pregnant:
- Your healthcare provider will do a pregnancy test to make sure that you are not pregnant before you start taking Verquvo.
- You must use effective forms of birth control during treatment and for 1 month after you stop treatment with Verquvo. Talk to your healthcare provider about forms of birth control that you may use to prevent pregnancy during treatment with Verquvo.
- Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with Verquvo.
Do not take Verquvo if you:
- are taking another medicine called a soluble guanylate cyclase stimulator (sGC). Ask your healthcare provider if you are not sure if you are taking an sGC medicine.
- are pregnant.
Before you take Verquvo, tell your healthcare provider about all your medical conditions, including if you:
- are breastfeeding or plan to breastfeed. It is not known if Verquvo passes into your breast milk. Do not breastfeed if you take Verquvo. Talk with your healthcare provider about the best way to feed your baby if you take Verquvo.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain other medicines may affect how Verquvo works.
Verquvo (vericiguat) is a prescription heart medication used in adults who are having symptoms of chronic (long-lasting) heart failure to reduce the risk of hospitalization or death. Do not take Verquvo if pregnant or may become pregnant. The most common side effects of Verquvo include low blood pressure and low red blood cells (anemia).
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Related Disease Conditions
What Is a Good Resting Heart Rate by Age?
Normal resting heart rate (RHR) values can range from anywhere between 60-100 beats per minute (bpm). As cardiovascular fitness increases, the resting heart rate value decreases. Resting heart rate is the number of beats per minute the heart takes while a person is fully rested.
How the Heart Works: Sides, Chambers, and Function
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include chest pain, burning in the throat, difficulty swallowing, the feeling of food sticking in the throat, and a burning feeling in the chest. Causes of heartburn include dietary habits, lifestyle habits, and medical causes. Treatments for heartburn include lifestyle changes, OTC medication,prescription medication, and surgery.
Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms, including left arm pain and chest pain, are well known but other, more nonspecific symptoms may be associated with a heart attack. Nausea, vomiting, malaise, indigestion, sweating, shortness of breath, and fatigue may signal a heart attack. Heart attack symptoms and signs in women may differ from those in men.
Is a Resting Heart Rate of 50 Good?
A resting heart rate of 50 beats per minute (bpm) is good for you if you are an athlete or a medical practitioner. If you are not feeling dizzy or ill, a resting heart rate of 50 is a good indicator that your heart is functioning quite well.
GERD (Acid Reflux, Heartburn)
GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms of uncomplicated GERD are: heartburn, regurgitation, and nausea. Effective treatment is available for most patients with GERD.
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
Can a Chest Muscle Strain Feel Like a Heart Attack?
Chest muscle strains can cause sudden, acute pain that feels like a heart attack. Learn the signs of a chest muscle strain, what causes it, how doctors diagnose it, and what you can do to treat it.
What Are the Four Main Functions of the Heart?
The heart is a muscular organ situated in the chest just behind and slightly toward the left of the breastbone. The heart works all the time, pumping blood through the network of blood vessels called the arteries and veins. The heart is enclosed within a fluid-filled sac called the pericardium. The pericardium is a protective covering that produces fluid, which lubricates the heart and prevents friction between the heart and the surrounding organs.
What Is the Quickest Way to Get Rid of Heartburn?
Taking antacids is considered the quickest way to get rid of heartburn. These over-the-counter medications help neutralize stomach acid. They are one of the first recommended treatments. They may provide quick relief. However, antacid overuse can cause problems such as diarrhea or chronic kidney disease, especially if they contain aluminum and magnesium.
Heart Attack (Myocardial Infarction)
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
An arrhythmia is an abnormal heart rhythm. With an arrhythmia, the heartbeats may be irregular or too slow (bradycardia), to rapid (tachycardia), or too early. When a single heartbeat occurs earlier than normal, it is called a premature contraction.
Heartburn vs. Acid Reflux (Differences and Similarities)
Heartburn and acid reflux are not the same thing. Heartburn is actually a symptom of acid reflux. Heartburn gets its name because it feels like a burning sensation around the heart. Another symptom that occurs with heartburn is a bitter or sour taste in the mouth, usually when you eat or lye down. Heartburn affects more than 60 million people in the US at least once a month. Acid reflux, or GERD, occurs when stomach acid backs up into the esophagus, which irritates it. Heartburn is just one symptom of acid reflux. Other symptoms of acid reflux include: Belching Nausea after eating A feeling of fullness during or after eating Abdominal bloating Upset stomach Belching Wheezing Reflux laryngitis A tightness in the throat Problems swallowing Indigestion In some people, vomiting Causes of acid reflux and heartburn include: Being obese Slouching (poor posture) Medications like calcium channel blockers, theophylline, nitrates, and antihistamines Foods and drinks like caffeine, citrus fruits and vegetables, alcohol, and chocolate Pregnancy Diabetes Increase in stomach acid Eating a heavy meal Eating before bed The treatment for heartburn and acid reflux is to treat the underlying cause, for example, GERD, with over-the-counter (OTC) medicine, prescription medicine, natural remedies, and lifestyle changes like a eating a healthy, less fatty, spicy diet, not eating big meals, not eating before bed, and getting regular exercise to improve your posture.Sometimes a heart attack can mimic heartburn and acid reflux because they feel very similar. If you have symptoms of chest pain, tightness in the chest, heartburn, acid reflux, jaw, tooth, or head pain; shortness of breath, nausea, vomiting, sweating, discomfort in the upper middle of the abdomen, arm or upper back pain, or the general feeling of being ill, go to the nearest Emergency Department immediately because these are the symptoms of a heart attack.REFERENCES:American College of Gastroenterology. "Acid Reflux." 2017.<http://patients.gi.org/topics/acid-reflux/> familydoctor.org. "Heartburn." Updated: Mar 2014.<https://familydoctor.org/condition/heartburn/> National Library of Medicine; PubMed Health. "Heartburn and GERD: Treatment options for GERD." Updated: Nov 18, 2015.<https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072436/>
What Are the 4 Stages of Congestive Heart Failure?
The New York Heart Association developed the four stages of congestive heart failure depending on the functional capabilities of the heart which includes Class I, Class II, Class III, and Class IV.
Arrhythmias (Heart Rhythm Disorders)
Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions (PVCs), sinus tachycardia, and sinus bradycardia, to abnormal heart rhythms such as tachycardia, ventricular fibrillation, ventricular flutter, atrial fibrillation, atrial flutter, paroxysmal supraventricular tachycardia (PSVT), Wolf-Parkinson-White syndrome, brachycardia, or heart blocks. Treatment is dependent upon the type of heart rhythm disorder.
Ways to Relieve Acid Reflux (GERD, Heartburn)
Most people have experienced some sort of pain or discomfort following a large meal or a particular food that didn’t quite agree with their stomach. Acid reflux symptoms can happen without a specific underlying condition.
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and conditions that overwork the heart. Symptoms of heart failure include congested lungs, fluid and water retention, dizziness, fatigue and weakness, and rapid or irregular heartbeats. There are two types of congestive heart failure, systolic or left-sided heart failure; and diastolic or right-sided heart failure. Treatment, prognosis, and life-expectancy for a person with congestive heart failure depends upon the stage of the disease.
A heart murmur is a heart problem that can occur, for example, during pregnancy or exercise, or it can be a symptom of serious heart condition, for example, congenital heart defects or heart valve disease. A heart murmur makes a whooshing or swishing sound. Symptoms of a heart murmur include swelling of the legs or feet, dizzy or lightheaded, blackouts, chest pain, rapid heart rate (palpitations), difficulty doing normal daily activities, fatigue, and a bluish tinge on the skin, lips, and fingernails. Treatment for heart murmurs in infants, children, and adults depend on the cause. Some heart murmurs can be harmless while some are serious and life threatening.
Heartburn During Pregnancy
Heartburn during pregnancy is quite common. During pregnancy the lower esophageal sphincter muscle becomes weakened , which likely occurs due to the effect of the high levels of the hormones estrogen and progesterone during pregnancy. Fortunately, this resolves after pregnancy. Management of heartburn during pregnancy are generally involves lifestyle changes and avoiding foods that promote heartburn, for example, don't smoke, avoid tight clothing, eat small, frequent meals, chew gum, or sip liquids.
How Long Can You Live With Heart Valve Disease?
The heart has two upper (atria) and two lower chambers (ventricles). There are certain structures, called valves, present in the heart to regulate the flow of blood into, within, and out of the heart. These valves are flaps present at specific junctions in the heart.
What Does a Broken Heart Feel Like?
Falling in love marinates our brain in “feel good” chemicals of its own making. After a breakup or the death of a loved one, the brain stops producing these chemicals, and the body literally suffers from withdrawal of these feel-good hormones.
Beyond Food: What Triggers Heartburn and GERD?
Heartburn is the burning sensation in the chest due to backflow or reflux of the acidic stomach contents into the food pipe (esophagus). Heartburn is a major symptom of gastroesophageal reflux disease or GERD.
Heart Disease: Sudden Cardiac Death
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Second Source WebMD Medical Reference
Second Source article from Government
Survival Rate of Heart Valve Replacement Surgery
The survival rate for a heart valve replacement surgery depends on which valve is involved. This was analyzed in a large study in which the lifespan of a large population, who went ahead with the surgery, is observed for a specific timeframe.
Second Source WebMD Medical Reference
Heart Attack vs. Stroke Symptoms, Differences, and Similarities
Heart attack usually is caused by a clot that stops blood flow supplying oxygen to an area of heart muscle, which results in heart muscle death. Stroke or "brain attack" is caused by a loss of blood supply to the brain (usually a blood clot) or by hemorrhagic stroke (bleeding within the brain), which results in brain tissue death. Both heart attack and stroke usually come on suddenly, produce similar symptoms, can be disabling, and can be fatal. The classic symptoms and warning signs of heart attack are different. Classic heart attack warning signs are chest pain or discomfort, shortness of breath, pain that radiates to the shoulders, back, arms, belly, jaw, or teeth, sweating, fainting, and nausea and vomiting. Moreover, woman having a heart attack may have additional symptoms like abdominal pain or discomfort, dizziness, clammy skin, and moderate to severe fatigue. The classic symptoms and warning signs that a person is having a stroke are confusion or loss of consciousness, sudden severe headache, speech problems, problems seeing out of one or both eyes, and numbness or weakness of only one side of the body. Moreover, a woman having a stroke may have additional warning symptom and signs like shortness of breath, disorientation, agitation, behavioral changes, weakness, nausea, vomiting, seizures, and hiccups. Recognition of stroke symptoms is vital for emergency treatment. The acronym "FAST" stands for recognition of Facial drooping, Arm weakness, Speech difficulty, and a Time for action. If you experience the symptoms heart attack or stroke (FAST) or see them develop in another person, then contact 911 immediately.
Heart Attack vs. Heartburn
Heartburn is a symptom of another disease or medical problem and can be described as a feeling of burning in the chest accompanied by symptoms of nausea, vomiting, or a sour taste or food stuck in the back of the throat. Heart attack occurs when an artery in the heart is completely blocked by a blood clot, which causes that portion of heart muscle to die. Heart attack also has symptoms of chest pain, nausea, and vomiting, however, other warning signs and symptoms of a heart attack are unusual weakness or fatigue, and persistent and/or increased severity of symptoms over a few minutes. Heart attack is a life threatening emergency. If you think you or someone you are with is having a heart attack, call 911 immediately for urgent medical treatment. It may save your life.
Quick Relief For Heartburn
Heartburn refers to the burning sensation in the chest due to backflow or reflux of the acidic stomach contents into the food pipe (esophagus). If you are experiencing heartburn, you may ease the problem through various ways.
How Long Does It Take to Recover From a Heart Attack?
While it takes most people about 6-8 months to recover after a heart attack, overall recovery time depends on your general health, how severe the attack was, the type of treatment you received and when you received it.
Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a heart attack than men. High cholesterol, high blood pressure, obesity, and high triglycerides are contributors to heart disease. Some of the common symptoms of a heart attack in women include chest pain, shortness of breath, nausea, feeling faint or woozy, and more. Heart disease can be prevented by lifestyle changes and controlling high blood pressure, cholesterol, weight, and diseases such as diabetes.
Fitness: Exercises for a Healthy Heart
Regular exercise can help reduce the risk of heart disease. To achieve maximum benefits, do a mix of stretching exercises, aerobic activity, and strengthening exercise. Aim to get 20 to 30 minutes of aerobic exercise at least three to four times a week. Consult a doctor before exercising for the first time, especially if you have health problems.
Target Heart Rate Zone and Chart
Target heart rate zone is a term used to define a heart rate at which cardio exercises are to be done. Exercising regularly at a target heart rate ensures that there is minimum undue stress on the heart and maximum benefit from the exercises. The American Heart Association recommends people to exercise in their target heart rate zones, which are calculated as a percentage (usually between 50 and 85%) of your maximum (safe) heart rate.
What Does a Leaky Heart Valve Feel Like?
Many healthy people may have one or more valves that are slightly leaky, which do not cause any problems. The severity of the symptoms depends on the severity of the heart valve leak.
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to prevent or stop this damage to the heart muscle. Heart attack treatments included medications, procedures, and surgeries to protect the heart muscle against injury.
Is It Normal to Have Irregular Heartbeat After Ablation?
Cardiac (heart) ablation is a procedure performed to correct heart arrhythmias (irregular heart rhythm/beat). Cardiac ablation works by intentionally injuring or destroying (ablating) and scarring the tissue in the heart that triggers the abnormal heart rhythm.
How Long Can You Live With Heart Failure?
What is the life expectancy of people with heart failure? Learn about survival rates, determining factors, and lifestyle changes that may help increase your life expectancy.
What Are the Four Signs of an Impending Heart Attack?
A heart attack occurs when the blood vessel that supplies blood to your heart (coronary artery) gets blocked – partially or completely. The lack of blood supply means the heart does not get enough oxygen or nutrients.
Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may make risk factors for heart disease worse. The warning signs of stress can be physical, mental, emotional, or behavioral. Reducing stressors in an individuals life not only can lead to a more productive life, but may also decrease the risk for heart disease and causes of heart disease.
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures, and illustrations of diseased heart tissue and the mechanisms that lead to coronary artery disease, and possible heart attack. A coronary artery occlusion may be fatal, but most patients survive it. Death can occur when the occlusion leads to an abnormal heartbeat (severe arrhythmia) or death of heart muscle (extensive myocardial infarction).
Heart Valve Disease
Heart valve disease occurs when the heart valves do not work the way they should. Symptoms of valve disease include shortness of breath, weakness or dizziness, discomfort in your chest, palpitations, swelling of your ankles, feet or abdomen, and rapid weight gain.
What Are the Signs of a Heart Attack in Women?
Many women think that the typical signs of a heart attack like crushing chest pain and shortness of breath can be easily recognized and cannot be missed. The 4 silent signs of a heart attack are fatigue, chest pain, pain in the upper back, shoulder, arms, neck or jaw, and sleep disturbances.
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women and health professionals are not aware of the risk factors for heart disease in women and may delay diagnosis and treatment. Lifestyle factors such as diet, exercise, tobacco use, overweight/obesity, stress, alcohol consumption, and depression influence heart disease risk in women. High blood pressure, high cholesterol, and diabetes also increase women's risk of heart disease. Electrocardiogram (EKG or ECG), stress-ECG, endothelial testing, ankle-brachial index (ABI), echocardiogram, nuclear imaging, electron beam CT, and lab tests to assess blood lipids and biomarkers of inflammation are used to diagnose heart disease. Early diagnosis and treatment of heart disease in women saves lives. Heart disease can be prevented and reversed with lifestyle changes.
What Gets Rid of Heartburn Fast?
Learn what causes heartburn and how to get rid of heartburn fast.
What Causes Congestive Heart Failure?
Congestive heart failure is a chronic disease that progresses with time if left untreated. Heart failure can occur due to diseases of the heart, the blood vessels supplying oxygen and nutrients to the heart, or sometimes from factors outside the heart (extracardiac causes). With proper management, people who have congestive heart failure can lead nearly normal lives, depending on the severity of the condition.
How Serious Is a Heart Catheterization?
Cardiac catheterization is a minimally invasive procedure that is considered to be safe for most patients. The procedure helps doctors find and fix any heart problems. It is a low-risk procedure and complications are usually rare, but as with any procedure, complications may arise.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back.
Congenital Heart Defects
Congenital heart defects are heart problems that are present at birth. Genetics may play a role in some heart defects. Symptoms can range from nonexistent to severe and life-threatening. Fatigue, rapid breathing, and decreased blood circulation are a few possible symptoms of congenital heart defects. Many cases do not require any treatment. Procedures using catheters and surgery may be used to repair severe heart defects.
How Can I Take Care of My Heart at Home?
Heart disease is one of the leading causes of death in many countries. Keeping the heart healthy no matter how old you are may limit heart diseases and complications.
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart Association. Risk factors and symptoms of heart disease in women differ from those in men. Treatment may include lifestyle modification (diet, exercise, weight management, smoking cessation, stress reduction), medications, percutaneous intervention procedure (PCI), and coronary artery bypass grafting (CABG). Heart disease is reversible with treatment.
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are interconnected and affect your risk for heart disease or heart attack. For better heart health, avoid the following fried foods, hard margarine, commercial baked goods, most packaged and processed snack foods, high fat dairy, and processed meats such as bacon, sausage, and deli meats.
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries. Learn how to quit smoking today, to prolong your life.
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause of heart failure. The process of developing atherosclerosis (hardening of the arteries) begins early in life. Heart attack prevention should begin in childhood because the atherosclerosis process can not be reversed. The risk of having a heart attack increases if you have diseases or conditions such as high blood pressure, diabetes, and other heart conditions.
Can Congenital Heart Defects Be Cured?
Congenital heart disease or a congenital heart defect is a medical condition that is present in an individual at birth. There are different types of congenital heart defects, ranging from simple conditions that don’t cause symptoms to complex ones that cause severe, life-threatening symptoms.
How Do I Know if It’s a Panic Attack or Heart Attack?
What is the difference between a panic attack and a heart attack?
Does COVID-19 Affect My Heart?
As per the American Heart Association, COVID-19 may have a long-term effect on the heart. Having a heart condition doesn't make a person more likely to catch COVID-19, but an individual with heart disease or a serious heart condition is more likely to become severely ill from COVID-19 and has a higher risk of death.
What Is a Widowmaker Heart Attack?
A Widowmaker is a type of heart attack, which is deadlier than most others. A widowmaker heart attack occurs when the left ascending artery (LAD) that supplies blood to the front part of the heart (largest part) is clogged-up because of clots in the arterial wall. This causes the death of heart muscle in this area, medically termed myocardial infarction. Because the widowmaker damages a major portion of the heart, timely management is necessary to prevent fatalities.
What Can Heartburn Be a Sign of?
Heartburn symptoms may indicate a bigger health concern. Learn more about heartburn, heartburn symptoms, heartburn related to other health conditions, how it's diagnosed, and your treatment options for heartburn.
Can Peripheral Artery Disease Affect the Heart?
Peripheral artery disease is a condition in which extremities (usually the legs) do not receive sufficient blood flow due to the narrowing of or blocks in arteries. Peripheral artery disease is also likely to be a sign of more widespread accumulation of fat deposits in the arteries (atherosclerosis or plaque).
Treatment & Diagnosis
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