Generic drug: valrubicin
Brand name: Valstar
What is Valstar (valrubicin), and how does it work?
What are the side effects of Valstar?
Common side effects of Valstar include:
- bladder irritation (symptoms such as pain, spasm, frequent urge to urinate, and
- blood in the urine),
- urinary incontinence,
- urinary tract infection, and
Valstar usually will cause urine to turn a reddish color for about 24 hours following a dose. This is a normal, harmless side effect of Valstar and should not be mistaken for blood in the urine.
What is the dosage for Valstar?
For Intravesical Use Only. Do NOT administer by intravenous or intramuscular routes.
Valstar is recommended at a dose of 800 mg administered intravesically once a week for six weeks. Delay administration at least two weeks after transurethral resection and/or fulguration.
Is Valstar safe to use while pregnant or breastfeeding?
- Based on findings in animal studies and its mechanism of action, Valstar can cause fetal harm when administered to a pregnant females.
- There are no available data in pregnant females to inform the drug-associated risk.
- There are no data on the presence of valrubicin or its metabolites in human milk, the effects of valrubicin on the breastfed infant, or its effects on milk production.
- Because of the potential for serious adverse reactions in breast-fed infants from valrubicin, advise a lactating female not to breastfeed during treatment with Valstar and for 2 weeks after the final dose.
Valstar (valrubicin) is a cancer (antineoplastic) medication used to treat bladder cancer. Common side effects of Valstar include bladder irritation (symptoms such as pain, spasm, frequent urge to urinate, and blood in the urine), urinary incontinence, urinary tract infection, and nausea.
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Related Disease Conditions
Second Source article from Government
Treatment for bladder cancer depends on the stage of the disease, the grade of the tumor, and the type of bladder cancer. Options for treatment include surgery, radiation therapy, chemotherapy, and biological therapy.
Interstitial Cystitis (IC) and Painful Bladder Syndrome (PBS)
Interstitial cystitis (IC)/painful bladder syndrome (PBS) is an inflammatory disease of the bladder that can cause ulceration and bleeding of the bladder's lining and can lead to scarring and stiffening of the bladder. Symptoms of interstitial cystitis may vary among individuals and may even vary with time in the same individual.
Overactive Bladder (OAB)
Overactive bladder is a sudden involuntary contraction of the muscle wall of the bladder causing urinary urgency (an immediate unstoppable need to urinate). Overactive bladder is is a form of urinary incontinence. Treatment options may include Kegel exercises, biofeedback, vaginal weight training, pelvic floor electrical stimulation, behavioral therapy, and medications.
A cystocele is also known as a fallen or prolapsed bladder. Heavy lifting and straining may cause a cystocele, which causes urine leakage and incomplete emptying of the bladder. Mild cystoceles may require no treatment, while large cystoceles may require surgery.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
Nerve Disease and Bladder Control
A nerve problem might affect your bladder control if the nerves that are supposed to carry messages between the brain and the bladder do not work properly. Such problems include urine retention, poor control of sphincter muscles, and overactive bladder. Treatment depends upon the cause of the nerve damage and resulting type of bladder control problem.
People who have bladder spasms, the sensation occurs suddenly and often severely. A spasm itself is the sudden, involuntary squeezing of a muscle. A bladder spasm, or "detrusor contraction," occurs when the bladder muscle squeezes suddenly without warning, causing an urgent need to release urine. The spasm can force urine from the bladder, causing leakage. When this happens, the condition is called urge incontinence or overactive bladder.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
What Neurological Disorders Cause Loss of Bladder Control?
Loss of bladder control is urinary incontinence. Severity ranges from occasionally leaking urine while straining, coughing or sneezing to having a frequent sudden urge to urinate. The causes of neurologic urinary incontinence include multiple sclerosis, Parkinson's disease, stroke, brain tumor, spinal injury and heavy metal poisoning.
How Can You Tell If Your Bladder Has Dropped?
The urinary bladder is a hollow organ in the pelvis that stores urine. During urination, urine leaves the bladder and exits the body through the urethra. The vagina supports the front of the bladder in women. This wall can weaken with age or get damaged during vaginal childbirth.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.