- A Visual Guide to PMS Slideshow
- Pelvic Inflammatory Disease (PID) Quiz: Test Your IQ
- Pelvic Pain Pictures Slideshow
What is Unasyn, and how does it work?
Unasyn is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below:
- Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli,* Klebsiella spp.* (including K. pneumoniae*), Proteus mirabilis,* Bacteroides fragilis,* Enterobacter spp.,* and Acinetobacter calcoaceticus.*
- Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K. pneumoniae*), Bacteroides spp. (including B. fragilis), and Enterobacter spp.*
- Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli,* and Bacteroides spp.* (including B. fragilis*).
* Efficacy for this organism in this organ system was studied in fewer than 10 infections.
While Unasyn is indicated only for the conditions listed above, infections caused by ampicillin-susceptible organisms are also amenable to treatment with Unasyn due to its ampicillin content. Therefore, mixed infections caused by ampicillin-susceptible organisms and beta-lactamase producing organisms susceptible to Unasyn should not require the addition of another antibacterial.
Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify the organisms causing infection and to determine their susceptibility to Unasyn.
Therapy may be instituted prior to obtaining the results from bacteriological and susceptibility studies when there is reason to believe the infection may involve any of the beta-lactamase producing organisms listed above in the indicated organ systems. Once the results are known, therapy should be adjusted if appropriate.
To reduce the development of drug-resistant bacteria and maintain effectiveness of Unasyn and other antibacterial drugs, Unasyn should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
What are the side effects of Unasyn?
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Unasyn and other antibacterial drugs, Unasyn should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.
What is the dosage for Unasyn?
- Unasyn may be administered by either the IV or the IM routes.
- For IV administration, the dose can be given by slow intravenous injection over at least 10-15 minutes or can also be delivered in greater dilutions with 50-100 mL of a compatible diluent as an intravenous infusion over 15-30 minutes.
- Unasyn may be administered by deep intramuscular injection.
- The recommended adult dosage of Unasyn is 1.5 g (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) to 3 g (2 g ampicillin as the sodium salt plus 1 g sulbactam as the sodium salt) every six hours.
- This 1.5 to 3 g range represents the total of ampicillin content plus the sulbactam content of Unasyn, and corresponds to a range of 1 g ampicillin/0.5 g sulbactam to 2 g ampicillin/1 g sulbactam. The total dose of sulbactam should not exceed 4 grams per day.
Pediatric Patients 1 Year Of Age Or Older
- The recommended daily dose of Unasyn in pediatric patients is 300 mg per kg of body weight administered via intravenous infusion in equally divided doses every 6 hours.
- This 300 mg/kg/day dosage represents the total ampicillin content plus the sulbactam content of Unasyn, and corresponds to 200 mg ampicillin/100 mg sulbactam per kg per day.
- The safety and efficacy of Unasyn administered via intramuscular injection in pediatric patients have not been established. Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations, and the total dose of sulbactam should not exceed 4 grams per day.
- The course of intravenous therapy should not routinely exceed 14 days.
- In clinical trials, most children received a course of oral antimicrobials following initial treatment with intravenous Unasyn.
Impaired Renal Function
- In patients with impairment of renal function the elimination kinetics of ampicillin and sulbactam are similarly affected, hence the ratio of one to the other will remain constant whatever the renal function.
- The dose of Unasyn in such patients should be administered less frequently in accordance with the usual practice for ampicillin and according to the following recommendations:
TABLE 5 Unasyn Dosage Guide for Patients with Renal Impairment
|Creatinine Clearance (mL/min/1.73m2)||Ampicillin/Sulbactam Half-Life (Hours)||Recommended Unasyn Dosage|
|≥30||1||1.5-3 g q 6h-q 8h|
|15-29||5||1.5-3 g q 12h|
|5-14||9||1.5-3 g q 24h|
When only serum creatinine is available, the following formula (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function.
|Males:||(weight in kg) x (140 - age)|
|(72) x serum creatinine (mg/100 mL)|
|Females:||(0.85) x (above value)|
Compatibility, Reconstitution And Stability
- Unasyn sterile powder is to be stored at or below 30°C (86°F) prior to reconstitution.
- When concomitant therapy with aminoglycosides is indicated, Unasyn and aminoglycosides should be reconstituted and administered separately, due to the in vitro inactivation of aminoglycosides by any of the aminopenicillins.
What drugs interact with Unasyn?
- Probenecid decreases the renal tubular secretion of ampicillin and sulbactam.
- Concurrent use of probenecid with Unasyn may result in increased and prolonged blood levels of ampicillin and sulbactam.
- The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone.
- It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
- There are no data with Unasyn and allopurinol administered concurrently.
- Unasyn and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of Unasyn.
Is Unasyn safe to use while pregnant or breastfeeding?
- Reproduction studies have been performed in mice, rats, and rabbits at doses up to ten (10) times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to Unasyn.
- There are, however, no adequate and well-controlled studies in pregnant women.
- Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Low concentrations of ampicillin and sulbactam are excreted in the milk; therefore, caution should be exercised when Unasyn is administered to a nursing woman.
Latest Women's Health News
Daily Health News
Unasyn is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in conditions such as skin and skin structure infections, intra-abdominal infections, and gynecological infections.
Multimedia: Slideshows, Images & Quizzes
Do I Have Pneumonia? Symptoms & Signs
Pneumonia can be deadly. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease.
Bacterial Infections 101: Types, Symptoms, and Treatments
Get more information on bacterial skin infections, which bacteria cause food poisoning, sexually transmitted bacteria, and more....
Skin Infections: Types, Causes, and Symptoms
Viruses, bacteria, and fungi can all cause skin infections. What is scabies? Learn about golden staph infections, cellulitis,...
Related Disease Conditions
Second Source article from Government
Pneumonia (Symptoms, Causes, Types, Treatment, and Recovery)
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
Is Pneumonia Contagious?
Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. If inflammation affects both lungs, the infection is termed double pneumonia. If it affects one lung, it is termed single pneumonia. If it affects only a certain lobe of a lung it's termed lobar pneumonia. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue.
Yeast infections vs. STDs in Men and Women
How Long Is Pneumonia Contagious?
Pneumonia may be contagious for 2-14 days. Usually, the goal of medications given for pneumonia is to limit the spread of the disease.
Can Pneumonia Go Away On Its Own?
Mild pneumonia may be healed by body’s defense system. However severe cases of pneumonia require medical attention especially viral pneumonia.
Staph Infection Causes
Staph or Staphylococcus is a group of bacteria that is found over the skin of most individuals. Staph bacteria usually live inside the nose, but they do not cause an infection. Staph infections may turn deadly if the bacteria invade deeper into the body, entering the bloodstream, joints, bones, lungs, or heart.
Treatment & Diagnosis
- Pneumonia FAQs
- Pneumonia ... Quick New Urine Test
- Pneumonia Vaccination: Who Should Have One?
- Is It Easier to Get Staph Infection When You've Had it Before?
- How Do You Get Staph Infection?
- How to Get Rid of a Staph Infection
- Should I Get the Pneumonia Vaccine Every Year?
- How Long Is Pneumonia Contagious?
- Pneumonia Symptoms
- E. coli Infection Facts
- Pneumonia Treatment
- Pneumonia vs. Walking Pneumonia
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.