Tylenol Liver Damage: Symptoms & Signs

Medically Reviewed on 4/27/2021

Tylenol liver damage is damage to the liver that occurs due to overdose of the drug acetaminophen. When used properly, acetaminophen is a safe and effective pain-relieving drug. Acetaminophen is found in many over-the-counter preparations as well as some prescription drugs like Vicodin.

Signs and symptoms of Tylenol liver damage can include

Cause of Tylenol liver damage

Overdose of acetaminophen, or the use of acetaminophen with excessive alcohol consumption, can damage the liver. The cause of the damage is the conversion of small amounts of acetaminophen to a harmful by-product called NAPQI (N-acetyl-p-benzoquinone imine). In recommended doses, the body can easily remove this toxic by-product. However, with excessive doses, the toxic metabolite accumulates and can damage the liver cells.

Other tylenol liver damage symptoms and signs


Long-term heavy alcohol consumption can cause: See Answer

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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.