- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: trolamine salicylate
Brand Names: Aspercreme Cream, Flex-Power Performance Sports, Myoflex Cream, Sportscreme
Drug Class: Analgesics, Topical
What is trolamine salicylate, and what is it used for?
Trolamine salicylate is a medication used for temporary relief from mild to moderate aches and pains of muscles and joints, associated with conditions such as arthritis, rheumatism, lower back pain, muscle sprains and strains, muscle soreness from exercise, cramps, bruises, and tendon or ligament pains. Trolamine salicylate is a topical pain-relief (analgesic) cream available over the counter (OTC). Trolamine salicylate relieves pain by reducing inflammation in the treatment region, however, it does not cure the underlying condition.
Trolamine salicylate works by inhibiting the activity of cyclo-oxygenase (COX) enzymes, which are responsible for initiating inflammatory responses in muscle and joint disorders. COX enzymes initiate the synthesis and release of pro-inflammatory substances such as prostaglandins and thromboxane when there is an injury or inflammation in the joints or muscles, which results in pain, swelling and other inflammation symptoms. Trolamine salicylate inhibits the inflammatory process and temporarily prevents pain generation.
Who should not use trolamine salicylate?
- Do not use if you are hypersensitive to salicylates, aspirin, trolamine salicylate, or any of its components. Use with caution if you are prone to allergic reactions.
- Do not use trolamine salicylate to treat children younger than 2 years of age.
- Avoid applying trolamine salicylate over a large area or for prolonged periods, particularly in young children.
- Do not apply on wounds or damaged skin.
- Do not cover tightly with a bandage.
- Do not apply external heat, including a heat pad, after topical application.
- Avoid contact with eyes and mucous membranes.
- Stop using trolamine salicylate and consult with your physician if
- Your condition worsens
- Redness of the skin occurs
- You develop skin irritation
- Symptoms persist for more than 7 days or clear up and reoccur within a few days
What are the side effects of trolamine salicylate?
Common side effects of trolamine salicylate include:
- Application site reactions such as:
- Fast breathing (hyperventilation)
- Ringing in the ears (tinnitus)
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of trolamine salicylate?
Analgesia for Minor Muscle/Joint Pain
- Apply liberal amount topically to affected area and massage three/four times daily
- Children below 2 years: Safety and efficacy not established
- Children above 2 years: Apply liberal amount topically to affected area and massage three/four times daily
- Topical use of trolamine salicylate is unlikely to result in overdose. Oral ingestion of trolamine salicylate can be harmful.
What drugs interact with trolamine salicylate?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Trolamine salicylate has no listed severe or serious interactions with other drugs.
- Moderate interactions of trolamine salicylate include:
- Trolamine salicylate has no listed mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- There are no adequate and well-controlled studies on the safety of trolamine salicylate use during pregnancy. Up to 20 weeks of pregnancy, trolamine salicylate may be used with caution in pregnant women, only if clearly needed. Trolamine salicylate is not recommended for use from 20 weeks of pregnancy until delivery.
- It is not known if trolamine salicylate is present in breast milk.
- If you are pregnant or breastfeeding, do not use any OTC products, including trolamine salicylate, without first checking with your healthcare provider.
What else should I know about trolamine salicylate?
- Use trolamine salicylate exactly as per label directions.
- Trolamine salicylate is for external use only.
- Avoid taking a bath or shower within 1 hour before or after application of trolamine salicylate.
- Store safely away from the reach of children.
- In case of oral ingestion of trolamine salicylate, seek immediate medical help or contact Poison Control.
- New COVID Variant XBB Is Gaining Ground Among Americans
- Berry Good for You: Some Foods Can Strengthen Your Brain
- Allergies & Asthma: Keep Sneezes & Wheezes at Bay This Holiday Season
- COVID in Pregnancy Can Vary — Get Vaccinated to Stay Safe
- Caregiving Can Heighten Loneliness, or Ease It
- More Health News »
Trolamine salicylate is a medication used for temporary relief from mild to moderate aches and pains of muscles and joints, associated with conditions such as arthritis, rheumatism, lower back pain, muscle sprains and strains, muscle soreness from exercise, cramps, bruises, and tendon or ligament pains. Common side effects of trolamine salicylate include blistering, peeling, redness, irritation, nausea, diarrhea, vomiting, fast breathing (hyperventilation), ringing in the ears (tinnitus), confusion, and drowsiness. Do not take if pregnant or breastfeeding.
Multimedia: Slideshows, Images & Quizzes
What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis
What is rheumatoid arthritis (RA)? Learn about treatment, diagnosis, and the symptoms of juvenile rheumatoid arthritis. Discover...
RA Home Remedies
People try all sorts of things to relieve rheumatoid arthritis pain. WebMD debunks some of the common ones and lets you know what...
Pain-Relief Tips for Bumps, Bruises, Sprains, and Strains in Pictures
View this First Aid slideshow on Care and Pain Relief. See how to get pain relief if you've bumped your head, sprained your...
Why Are My Joints So Stiff? What Can I Do?
You use your joints to bend, touch, type, drive -- to do just about everything. Find out more from WebMD about what can make your...
Arthritis: Everyday Habits to Ease Inflammation
Chronic inflammation harms your body and raises risk of disease. These everyday lifestyle changes can help lower it.
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Arthritis: Reasons Why Your Hips Hurt
You use them to sit, stand, dance, kick, and run. Find out from WebMD's slide show what makes your hips hurt, and what you can do...
Rheumatoid Arthritis Exercises: Joint-Friendly Workouts
Regular exercise boosts fitness and helps reverse joint stiffness for people with rheumatoid arthritis (RA). WebMD demonstrates...
Rheumatoid Arthritis Quiz: What is Rheumatoid Arthritis?
How is rheumatoid arthritis different from other forms of arthritis, such as osteoarthritis and gout? Take the Rheumatoid...
Picture of Knee Joint
The knee joint has three parts. See a picture of Knee Joint and learn more about the health topic.
Arthritis: Supplements for Joint Pain
Can supplements help relieve joint pain and swelling? Find out how certain compounds may aid your stiff, tender joints.
Tips for Healthy Joints: Exercise, Nutrition, & More
Dealing with joint pain and arthritis? Learn why weight matters--and why NOT to stretch before exercise. See these solutions for...
Arthritis: 16 Bad Habits That Cause Joint Pain
Being overweight, wearing uncomfortable shoes, or carrying a heavy purse can make joint pain and arthritis symptoms worse. Some...
Arthritis: Causes and Treatment for Joint Stiffness and Pain
Arthritis and injuries can leave your joints swollen, tender, and damaged. Discover treatments for morning stiffness, sore...
Arthritis: Ways to Ease Hip Pain
Health habits, home remedies, and other ways you can find relief when your hips hurt.
Related Disease Conditions
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.
Pain Management and Rheumatoid Arthritis
Second Source article from WebMD
Temporomandibular Joint Disorders (TMJ, TMD)
Second Source WebMD Medical Reference
Temporomandibular Joint Syndrome (TMJ)
Temporomandibular joint (TMJ) syndrome is a disorder that causes symptoms like pain, clicking, and popping of the jaw. TMJ is caused by injury to the temporomandibular joint. Stress, poor posture, jaw trauma, genetic predisposition, and inflammatory disorders are risk factors for the condition. A variety of self-care measures (application of ice, use of over-the-counter pain medication, massage, relaxation techniques) and medical treatment options (dental splint, Botox, prescription medications, surgery) are available to manage TMJ. The prognosis of TMJ is good with proper treatment.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Which Foods Make Arthritis Worse?
Certain foods can contribute to arthritis joint inflammation, like processed foods high in salt, alcohol, red meat, and others. Foods that are good for the joints are beans, greens, and other whole foods that have high fiber and nutrient content and low calories.
Sacroiliac (SI) Joint Pain
Sacroiliac (SI) joint pain is a general term to reflect pain in the SI joints. Causes of SI joint pain include osteoarthritis, abnormal walking pattern, and disorders that can cause SI joint inflammation including gout, rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Treatment includes oral medications, cortisone injections, and surgery.
16 Early Rheumatoid Arthritis (RA) Signs & Symptoms
Early rheumatoid arthritis (RA) symptoms and signs vary differently from person to person. The most common body parts that are initially affected by RA include the small joints of the hands, wrists, and feet, and the knees and hip joints. Joint inflammation causes stiffness. Warmth, redness, and pain may vary in degree.
How Long Does a Strained Back Take to Heal?
When the lower spine muscles become swollen and inflamed, this is known as a strain. The majority of back strain pain will go away without help in one to four weeks.
Is a Muscle Strain the Same as a Muscle Tear?
What is the difference between a muscle strain and a muscle tear?
Sprains and Strains
An injury to a ligament is called a sprain, and an injury to muscle or tendon is called a strain. Sprains and strains may be caused by repetitive movements or a single stressful incident. Symptoms and signs include pain and swelling. Though treatment depends upon the extent and location of the injury, rest, ice, compression, and elevation are key elements of treatment.
What Foods Worsen Rheumatoid Arthritis?
A diet high in processed foods and sugary drinks has been shown to aggravate symptoms of rheumatoid arthritis. Check out the center below for more medical references on rheumatoid arthritis, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
12 Early Signs of Arthritis in Hands
Hand arthritis occurs when there is inflammation in one or more joints of the hand and wrist. A few of the common types of arthritis that affect the hands are osteoarthritis, rheumatoid arthritis, post-traumatic arthritis (arthritis as a result of an injury), psoriatic arthritis and gout.
How Long Does it Take for an Oblique Strain to Heal?
An oblique strain is a specific injury that affects your abdominal muscles. An oblique strain may heal within a few weeks to six weeks.
How Do You Tell If a Tendon Is Torn or Strained?
Learn the symptoms of a tendon tear and strain below, which include swelling, redness, severe pain, and an inability to move the affected limb.
Osteoarthritis vs. Osteoporosis Differences and Similarities
Arthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
Can Rheumatoid Arthritis Cause Heart Failure?
Rheumatoid arthritis can increase the risk of various cardiovascular diseases including heart failure and pericarditis. Heart failure is one of the common causes of increased mortality in people with RA.
What Foods Cause Joint Pain?
With arthritis, the constant pain and stiffness often lead the body to be in a state of stress or "inflammation." Foods that cause joint pain include heavily processed foods, red meat, foods high in sugar, fried foods, alcohol and foods rich in MSG, refined carbohydrates, gluten and purines.
How Long Does It Take for a Strained Muscle in the Arm to Heal?
A muscle strain refers to tearing or stretching of the muscle fibers. Typically, a strained arm muscle heals in a few weeks to a few months, depending on the extent of the injury to the muscle.
How Long Before a Strained Neck Muscle Heals?
A neck strain is an injury to the muscles or tendons of your neck muscles and tendons — two types of soft tissue. It typically takes days to weeks for strains to heal.
Arthritis in Knee: 4 Stages of Osteoarthritis
Painful joint swelling is called arthritis. Osteoarthritis is due to wear and tear of the joints over many years. Arthritis maye develop in any joint, including the fingers, hips and knees. Usually, patients with arthritis feel pain in their joints even after moderate movements. There are four stages of osteoarthritis of the knee.
How Long Does It Take for a Strained Leg Muscle to Heal?
A muscle strain usually results when it is overly stretched, and the muscle fibers tear. A mild or grade I strain may need ten days to three weeks to heal where a severe strain to the hamstrings may take up to six months.
11 Home Remedies for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-term disorder that progressively affects many parts of the body. Home remedies, diet, and lifestyle changes can help reduce pain and discomfort associated with RA alongside medical treatment. Home remedies alone cannot effectively treat RA or prevent the progression of the disease.
Why Is My Thumb Joint So Painful?
Causes of thumb joint pain include trigger thumb, thumb arthritis, carpal tunnel syndrome, De Quervain's tendonitis, and skier's thumb.
What Foods Trigger Arthritis Attacks?
Exercising regularly and eating a healthy diet can help you manage arthritis. Learn which foods to avoid and which foods to eat with arthritis.
Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than 6 weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
How Long Should a Sprained Thumb Hurt?
Thumb sprains can take anywhere from 2-12 weeks to heal depending on the severity of the sprain. Learn about how sprains are graded, diagnosed, and treated.
How Long Does It Take for Repetitive Strain Injury to Heal?
A repetitive strain injury (RSI) can heal within a few weeks to six months depending on the severity of the injury and available medical treatment.
Will Joint Pain From Menopause Go Away?
Whether joint pain from menopause will go away depends on whether the joint pain is purely due to hormonal changes seen in menopause or due to other associated factors.
How Bad Is a Grade II Hamstring Strain?
Grade II hamstring strain, known as a partial tear, is typically more painful and may result in some swelling or bruising. The injury should heal on its own with rest and proper physiotherapy.
Can Rheumatoid Arthritis Be Caused by Stress?
Rheumatoid arthritis can be caused by and result in stress, as well as other conditions such as gastrointestinal problems (IBD).
What Does a Rheumatoid Arthritis Rash Look Like?
Rheumatoid arthritis can cause a raised red, purple, or blue rash that appears on the arms, legs, or torso. Check out the center below for more medical references on rheumatoid arthritis, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
What Are the Four Stages of Rheumatoid Arthritis?
Rheumatoid arthritis is a chronic inflammatory disease categorized into the following four stages and classifications. Learn the causes, symptoms, and complications of RA below.
Rheumatoid Arthritis vs. Arthritis
Arthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.
Do Steroids Help With Arthritis?
Arthritis is the inflammation of one or more joints in the body. The disease is one of the most common chronic health conditions in the United States. Steroids are a class of drugs that reduce inflammation and have a suppressing effect on the immune system.
What Does Psoriatic Arthritis Joint Pain Feel Like?
Psoriatic arthritis may lead to various degrees of inflammation, swelling, stiffness, and pain in the joints, especially on one side of the body. Pain caused in the joints can be debilitating and reduce mobility.
Does Hand Grip Help With Arthritis?
Because your hands are engaged in multiple functions every day, hand strength is a powerful predictor of your overall capacity to function and how severe your arthritis is.
How Do You Stop Arthritis From Progressing in Your Hands?
Learn these simple tips and tricks to help stop the progression of arthritis in your hands.
How Long Should It Take for a Sprained Ankle to Heal?
Depending on the severity of the sprain, a sprained ankle generally heals within 2 to 12 weeks of home management with proper treatment.
Safest Rheumatoid Arthritis Drugs During Pregnancy
None of the drugs used in the treatment of rheumatoid arthritis (RA) is completely safe during pregnancy. You must discuss with your physician regarding the decision to use, modify, or stop any medications.
What Are the Three Grades of Muscle Strain?
Depending on the severity of damage, muscle strains are classified into three grades. Learn about symptoms, causes, and treatment.
How Serious Is Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that typically affects the joints and other body parts. If not diagnosed early and appropriately treated, RA can lead to permanent deformities, disabilities, and serious systemic complications.
Breastfeeding With Rheumatoid Arthritis
You can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
Early Signs of Arthritis in the Fingers
The earliest signs of arthritis are pain, swelling and stiffness. If these symptoms are experienced in the fingers, it is likely because of rheumatoid arthritis. The signs and symptoms of arthritis in the fingers include popping sounds, joint deformity, warmth, mucus cysts and bone spurs.
How Do You Fix a High Ankle Sprain?
Treatment for a high ankle sprain typically follows the standard “RICE” protocol, which stands for rest, ice, compression, and elevation. More severe high ankle sprains may require surgery, taping, or braces.
What Is an Acromioclavicular Joint Injection?
Injecting corticosteroids into the AC joint is a method to treat its injuries or pain.
What Are the Best Exercises for SI Joint Pain?
When the ligaments in the sacroiliac joint become too lax or tight, it can cause pain. Here are the eight best exercises you can do for SI joint pain.
How Do You Make Your Joints Stronger?
Losing bone and muscle mass with age can lead to joint pain. Here are 5 tips to make your joints stronger so that you can keep joint problems at bay.
Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
What Does a Bicep Strain Feel Like?
Bicep pain is the most common symptom of a strained bicep, which may be accompanied by a popping sound, weakness in the shoulder or elbow, and bruising. Learn about the causes, diagnosis, and treatment of bicep strains. Check out the center below for more medical references on muscle injuries, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
Early Signs of Arthritis in Shoulder
Early signs and symptoms of arthritis in the shoulder include pain in the shoulder joint that's worse when lifting heavy objects, pain that radiates down the arm and shoulder joint sounds like grinding, clicking, and crackling.
How Do You Treat a Groin Strain?
A groin train may be treated with painkillers to manage symptoms and physical therapy to regain muscle strength. Surgery may be required in severe cases.
What Joints Does Palindromic Rheumatism Affect?
Palindromic rheumatism typically involves the major, large joints of the hand, often the metacarpophalangeal and proximal interphalangeal joints.
What Are 5 Common Risk Factors to Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is an autoimmune disorder (the body's immune system mistakenly attacks its own cells). Certain factors increase the risk of RA.
Osteoarthritis and Treatment
Painful swelling of the joints due to wear and tear over many years is called osteoarthritis. Osteoarthritis may develop in any joint that includes the fingers, hips, and knees. There are many treatment options available to curb the complications of arthritis.
What Can I Do for a Muscle Strain in My Back?
Muscle strain is sometimes called a pulled muscle. Treat a muscle strain in your back with ice, rest, compression, and heat or a see a doctor for an evaluation of a severe muscle strain in your back.
Treatment & Diagnosis
- Rheumatoid Arthritis FAQs
- Arthritis Medications
- Arthritis: Dr. Shiels Handshake
- Rheumatoid Arthritis Joint Symptoms and Signs: What Do They Mean?
- Patient Story: Rheumatoid Arthritis and Pregnancy
- How Do Arthritis Symptoms Start?
- Ultrasound Imaging of Joints in Rheumatoid Arthritis (RA)
- Can Fifth Disease Cause Arthritis Pain?
- What Can You Take for MCTD Inflammation Beside NSAIDs?
- What Kind of Joint Injections Treat Osteoarthritis?
- Does Magnetic Therapy for Arthritis Work?
- Can Glucosamine Treat Arthritis?
- Can You Have a Joint Aspiration on Coumadin (warfarin)?
- Can Microscopic Colitis Cause Joint Pain?
- Symptoms and Signs of Sprains and Strains
- Home Remedies, Treatment, and Prevention of Sprains and Strains
- Diagnosing Sprains and Strains
- Patient Story: Rheumatoid Arthritis Treatment
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.