GENERIC NAME: TRIMETHOBENZAMIDE - INJECTION (try-meth-oh-BENZ-uh-mide)
BRAND NAME(S): Tigan
USES: This medication is used to treat nausea and vomiting that can occur following surgery or with certain stomach/intestinal problems (e.g., gastroenteritis). Treating vomiting quickly can prevent a serious loss of body water (dehydration). Trimethobenzamide belongs to a class of drugs known as antiemetics. It works by decreasing the signals in the brain that lead to vomiting.Trimethobenzamide injection must not be used in children.
HOW TO USE: Inject this medication into a large muscle of the buttock, usually 3-4 times a day as needed or as directed by your doctor. This medication should not be injected into a vein. Ask your doctor or pharmacist how to properly give this drug to lessen injection-related side effects.Before using, check the product visually for particles or discoloration. If either is present, do not use the liquid.Dosage is based on your medical condition and response to therapy. Take this medication exactly as directed to get the most benefit from it. Do not take more medication or take it more often than prescribed. Ask your doctor or pharmacist if you have questions.Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.Inform your doctor if your condition persists or worsens.
SIDE EFFECTS: Diarrhea, headache, dizziness, drowsiness, blurred vision, muscle cramps, or pain/stinging/burning/redness at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: confusion, muscle spasms, unusual uncontrolled movements (especially of the face, mouth, tongue, arms, or legs), shaking (tremor), restlessness, drooling.Tell your doctor immediately if any of these rare but very serious side effects occur: severe arching of the back, mouth sores, unusual bleeding/bruising, seizures, mental/mood changes (e.g., depression), yellowing eyes/skin, dark urine.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using trimethobenzamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high fever, kidney problems, stomach/intestinal problems (e.g., appendicitis), swelling/disease of the brain (encephalitis/encephalopathy), a serious loss of body water (dehydration), mineral (electrolyte) imbalance.This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to the effects of this drug.Trimethobenzamide injection must not be used in children.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents should call the US National Poison Hotline at 1-800-222-1222. Canada residents should call a provincial poison control center.
NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood counts, liver function) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
MISSED DOSE: If you use this medication regularly and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
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Nausea and Vomiting
Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia. Some causes of nausea and vomiting may be life-threatening, for example, heart attack, abdominal obstruction, and cancers. Treatment of nausea and vomiting depends upon the cause.
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