trimagnesium citrate anhydrous

Medically Reviewed on 1/17/2023

Generic Name: trimagnesium citrate anhydrous

Brand Name: Magnitria

Drug Class: Electrolytes

What is trimagnesium citrate anhydrous, and what is it used for?

Trimagnesium citrate anhydrous is a salt of magnesium and citric acid, used as a dietary supplement to treat and prevent magnesium deficiency (hypomagnesemia).

Trimagnesium citrate is a compound of magnesium ions and citrate molecules in the ratio of 3:2. Trimagnesium citrate anhydrous is available over the counter (OTC) as a dehydrated oral powder that provides adequate supplemental magnesium for patients with or at risk for magnesium deficiency.

Magnesium is one of the essential electrolytes that plays an important role in more than 300 biochemical reactions in the body. Magnesium is required for many biological functions, including neuromuscular activity, temperature regulation, synthesis of DNA and RNA, energy production through carbohydrate metabolism, and detoxification reactions.

Trimagnesium citrate anhydrous is used to treat or reduce the risk of hypomagnesemia in patients with:


  • Do not use trimagnesium citrate anhydrous in patients with:
    • High levels of magnesium in blood (hypermagnesemia)
    • Known hypersensitivity to proton pump inhibitors (PPIs)
    • Gastrointestinal obstructions
  • Use with caution in patients with impaired kidney function.
  • High fat content in food can reduce the absorption of magnesium.
  • Magnesium may enhance the neuromuscular blocking effect of neuromuscular blocking agents. Use with caution.
  • Avoid concomitant use with calcium polystyrene sulfonate.
  • Do not use concurrently with calcium channel blockers, magnesium may enhance their hypotensive effects.

What are the side effects of trimagnesium citrate anhydrous?

Common side effects of trimagnesium citrate anhydrous include:

Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:

This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.


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What are the dosages of trimagnesium citrate anhydrous?

Oral Powder

  • 1504 mg/powder sachet (elemental magnesium/sachet: 243 mg [20 mEq])


Magnesium Supplementation

  • Dietary supplement to treat or reduce the risk of magnesium deficiency
  • Dose based on elemental magnesium (Mg) 243-486 mg orally daily
  • If 486 mg/day administered, give as 2 doses 4-8 hours apart

Dosing Considerations

  • 243 mg elemental Mg provides 60% of recommended daily intake (RDI)
  • RDI for adults is 400 mg/day
  • Other ingredients: Xylitol, citric acid, natural and artificial orange flavor, dextrin, and sucralose


  • Mix with 4-8 oz of water, stir well, and drink
  • May take with or without food
  • Store in a dry location at 59-86 degrees F (15-30 degrees C)


  • Safety and efficacy not established


  • Trimagnesium citrate anhydrous overdose symptoms include diarrhea and stomach pain, which should resolve with the discontinuation of the drug.

What drugs interact with trimagnesium citrate anhydrous?

Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.

  • Trimagnesium citrate anhydrous has no listed severe interactions with other drugs.
  • Serious interactions of trimagnesium citrate anhydrous include:
    • baloxavir marboxil
  • Trimagnesium citrate anhydrous has moderate interactions with at least 31 different drugs.
  • Trimagnesium citrate anhydrous has no listed mild interactions with other drugs.

The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.

It is important to always tell your doctor, pharmacist, or health care provider about all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or healthcare provider if you have any questions about the medication.

Pregnancy and breastfeeding

  • Trimagnesium citrate anhydrous use may be acceptable during pregnancy to maintain normal magnesium levels. Check with your physician for appropriate dosages.
  • Magnesium is present in breastmilk and concentrations remain constant during the first year of lactation. The effects of prolonged increments of supplemental magnesium are not known.
  • Check with your physician before taking any OTC drug, including trimagnesium citrate anhydrous, if you are pregnant or breastfeeding.

What else should I know about trimagnesium citrate anhydrous?

  • Take trimagnesium citrate anhydrous exactly as prescribed or as per label directions.
  • Avoid taking any OTC drug, including supplemental magnesium, without checking with your physician, if you have any ailment.
  • Discontinue use and inform your physician if you experience a sudden change in your bowel habits.
  • Store safely out of reach of children.
  • In case of overdose, seek medical help or contact Poison Control.


Trimagnesium citrate anhydrous is a salt of magnesium and citric acid, used as a dietary supplement to treat and prevent magnesium deficiency (hypomagnesemia) in people with congestive heart failure, high blood pressure (hypertension), Crohn’s disease, ulcerative colitis, celiac disease, and other conditions. Common side effects of trimagnesium citrate anhydrous include diarrhea, abdominal cramping, weakness (asthenia), muscle weakness, electrolyte imbalance, high magnesium levels in blood (hypermagnesemia), respiratory depression, low blood pressure (hypotension), and dizziness.

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Medically Reviewed on 1/17/2023