triazolam

Triazolam is a drug that is used to promote sleep in individuals who have difficulty sleeping (insomnia). It is in the benzodiazepine family of drugs, the same family that includes diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), flurazepam (Dalmane), lorazepam (Ativan), and others. Insomnia is believed often to be the result of anxiety, a state in which the brain is excessively active. Gamma-aminobutyric acid (GABA) is a substance produced in the brain which inhibits (slows down) nerves and many of the activities of the brain. Triazolam and other benzodiazepines enhance the effects of GABA and thereby reduce activity in the brain and promote sleep. Triazolam was approved by the FDA in 1982.

Halcion

GENERIC AVAILABLE: yes

yes

The most common side effects of triazolam are:

• weakness or tiredness,
• dizziness,
• drowsiness,
• clumsiness, or
• unsteadiness.

Other side effects include:

• "hangover" effects,
• headache,
• increased dreaming,
• loss of memory,
• nausea,
• vomiting,
• confusion,
• depression,
• lightheadedness or fainting spells,
• mood changes,
• excitability,
• aggressive behavior,
• movement difficulty,
• staggering or jerky movements,
• muscle cramps, and
• tremors.

Triazolam usually is prescribed once daily at bedtime to promote sleep.

• Individuals over the age of 65 years may require smaller doses to avoid side effects.
• The recommended dose is 0.125 to 0.25 mg at bedtime.
• The maximum dose is 0.5 mg at bedtime.

Benzodiazepines, including triazolam, add to the effects of other drugs that also inhibit activity within the brain, such as:

• alcohol,
• barbiturates,
• narcotics, and
• some over-the-counter antihistamines (for example, diphenhydramine [Benadryl], chlorpheniramine maleate [Chlor-Trimeton]).

Combining the above drugs with benzodiazepines may cause excessive sedation.

Some drugs block the metabolism (elimination) of triazolam from the body, thereby raising the levels of triazolam in the body and causing excessive sedation. Such drugs include:

• cimetidine (Tagamet),
• erythromycin (E-Mycin; Estolate),
• clarithromycin (Biaxin),
• itraconazole (Sporanox),
• ketoconazole (Nizoral),
• fluconazole (Diflucan),
• telaprevir (Incivek),
• nelfinavir (Viracept),
• fluvoxamine (Luvox).
• Grapefruit juice can have a similar effect.

Phenytoin (Dilantin), carbamazepine (Tegretol), rifampin (Rifadin), and rifabutin (Mycobutin) increase the rate of elimination of triazolam from the body and can lead to a loss of triazolam's effectiveness.

Triazolam is contraindicated during pregnancy because benzodiazepines are associated with fetal abnormalities when used during pregnancy.

It is not known whether triazolam is secreted into human breast milk. Other benzodiazepines are, however, and it is likely that triazolam is as well. It should be avoided while breastfeeding.

What preparations of triazolam are available?

Tablets: 0.125mg and 0.25mg.

How should I keep triazolam stored?

Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).