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- What is triamterene and hydrochlorothiazide, and how does it work (mechanism of action)?
- What brand names are available for triamterene and hydrochlorothiazide?
- Is triamterene and hydrochlorothiazide available as a generic drug?
- Do I need a prescription for triamterene and hydrochlorothiazide?
- What are the side effects of triamterene and hydrochlorothiazide?
- What is the dosage for triamterene and hydrochlorothiazide?
- Which drugs or supplements interact with triamterene and hydrochlorothiazide?
- Is triamterene and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
- What else should I know about triamterene and hydrochlorothiazide?
What is triamterene and hydrochlorothiazide, and how does it work (mechanism of action)?
Triamterene/hydrochlorothiazide is an oral diuretic (water pill) that is used for treating high blood pressure (hypertension) and edema (water accumulation). It is a combination of two different diuretics. The FDA approved triamterene/hydrochlorothiazide in December 1965.
The kidneys control the amount of sodium and water within the body. Normally, blood circulates through the kidneys where much of the water, sodium and other small molecules are filtered out of the blood and into the tubules of the kidney. Once in the tubules, much of the water and sodium are reabsorbed back into the blood. The water and sodium that is not reabsorbed passes on through the tubules and becomes urine that is eliminated from the body. Diuretics affect the reabsorption of sodium and water from the tubules and thus, the amount of sodium and water retained or eliminated by the body. In addition to controlling sodium, the kidney also controls the amount of potassium that is retained or eliminated from the body.
Diuretics eliminate salt (sodium) and water from the body. Hydrochlorothiazide is a diuretic that can be used alone for treating high blood pressure and edema. It works by blocking sodium and water reabsorption in the kidneys, thereby reducing sodium and water in the body. (Whereas it is clear how hydrochlorothiazide eliminates water from the body, its mechanism of action in lowering high blood pressure is not well understood.) To compensate for the increased amount of sodium and water in the tubules that will be lost as urine, the kidney tries to reabsorb more sodium and water. It does this by removing potassium from the blood and putting it into the tubules in exchange for sodium (and water) in the tubules. As a result, blood potassium levels fall. Triamterene is a diuretic that prevents reabsorption of sodium in exchange for potassium. Thus, it reduces sodium and water in the body but also prevents the depletion of potassium. For this reason, triamterene is called a potassium sparing diuretic. By combining hydrochlorothiazide with triamterene, sodium and water are eliminated from the body without the loss of potassium. However, this drug may allow potassium levels to increase so potassium levels should be closely monitored.
What are the side effects of triamterene and hydrochlorothiazide?
Side effects of triamterene/hydrochlorothiazide include abdominal pain, nausea, vomiting, rash, headache, dizziness, constipation, low blood pressure, electrolyte disturbance (for example, high potassium levels), muscle cramps, hypersensitivity, pancreatitis, and jaundice. Triamterene/hydrochlorothiazide may increase blood sugar (glucose) levels and precipitate or worsen diabetes. Patients allergic to sulfa drugs may also be allergic to hydrochlorothiazide because of the similarity in the chemical structure of the two drugs.
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What is the dosage for triamterene and hydrochlorothiazide?
The recommended dose is 1-2 tablets or capsules daily. The maximum dose is 75/50 mg daily. Like other diuretics, it should be taken in the morning in order to avoid excessive trips to the bathroom at night.
Which drugs or supplements interact with triamterene and hydrochlorothiazide?
Triamterene increases potassium levels in the body. Therefore, combining triamterene/hydrochlorothiazide with ACE inhibitors [for example, enalapril (Vasotec)], angiotensin receptor blockers [for example, losartan (Cozaar)], aliskiren (Tekturna), eplerenone (Inspra), potassium supplements or other drugs that also increase potassium may lead to dangerous potassium levels in the body.
Salt substitutes (for example, Mrs. Dash) contain potassium and may lead to excessive potassium levels in the body if combined with triamterene/hydrochlorothiazide.
Hydrochlorothiazide reduces the elimination of lithium (Lithobid) by the kidneys, increasing blood levels of lithium and lithium toxicity. Nonsteroidal antiinflammatory drugs, for example, ibuprofen, may reduce the blood pressure-reducing effects of triamterene/hydrochlorothiazide.
Is triamterene and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
Triamterene/hydrochlorothiazide has not been adequately studied in pregnant women.
Triamterene/hydrochlorothiazide has not been evaluated in nursing mothers. Hydrochlorothiazide is excreted in breast milk. Intense diuresis using hydrochlorothiazide may reduce the production of breast milk. Otherwise, hydrochlorothiazide is considered safe to use during nursing if required by the mother.
What else should I know about triamterene and hydrochlorothiazide?
What preparations of triamterene and hydrochlorothiazide are available?
Tablets: 37.5/25, 75/50 mg. Capsules: 37.5/25, 50/25 mg.
How should I keep triamterene and hydrochlorothiazide stored?
Triamterene/hydrochlorothiazide should be store at room temperature, 15 C - 30 C (59 F - 86 F).
Triamterene and hydrochlorothiazide (HCTZ, Maxzide, Dyazide) is a diuretic medication prescribed for the treatment of high blood pressure and edema. Side effects, drug interactions, and safety during pregnancy information should be reviewed prior to taking this medication.
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The prognosis is good for some people with cirrhosis of the liver, and the survival can be up to 12 years; however the life expectancy is about 6 months to 2 years for people with severe cirrhosis with major complications.
Congestive Heart Failure (CHF) OverviewCongestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
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Doctors also prescribe Lasix in conjunction with other high blood pressure pills to patients to treat high blood pressure (hypertension).
Profound diuresis with water and electrolyte depletion can occur if Lasix drug is given in excess amounts. Other side effects and adverse effects of this medicine include:
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- Systemic hypersensitivity reactions like severe anaphylactic shock, necrotizing angiitis, and interstitial nephritis.
- CNS (central nervous system) reactions like vertigo, headaches, blurred vision, tinnitus, and hearing loss.
- Blood reactions like anemia, leukopenia, thrombocytopenia, and eosinophilia.
- Hypersensitive skin reactions like rash, itching, hives, photosensitivity, exfoliative dermatitis, and Steven-Johnson syndrome.
- Heart reactions like orthostatic hypotension (fainting or dizziness when standing up) and an increase in triglyceride and cholesterol levels
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High Blood Pressure Hypertension
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms.
Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure.
The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater.
If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.
REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
High Blood Pressure Medication
High blood pressure (hypertension) medications include drugs from a variety of different drug classes and types.
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High Blood Pressure TreatmentHigh blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
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