Generic drug: clorazepate dipotassium
Brand name: Tranxene
What is Tranxene (clorazepate dipotassium), and how does it work?
Tranxene is a prescription medicine used:
- to treat anxiety disorders
- with other medicines to treat partial seizures
- to treat the symptoms of sudden alcohol withdrawal
It is not known if Tranxene is safe and effective in children less than 9 years of age.
What are the side effects of Tranxene?
The most common side effects of Tranxene include:
These are not all the possible side effects of Tranxene. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Tranxene?
For The Symptomatic Relief Of Anxiety
- Tranxene T-TAB tablets are administered orally in divided doses. The usual daily dose is 30 mg. The dose should be adjusted gradually within the range of 15 to 60 mg daily in accordance with the response of the patient. In elderly or debilitated patients it is advisable to initiate treatment at a daily dose of 7.5 to 15 mg.
- Tranxene tablets may also be administered in a single dose daily at bedtime; the recommended initial dose is 15 mg. After the initial dose, the response of the patient may require adjustment of subsequent dosage. Lower doses may be indicated in the elderly patient. Drowsiness may occur at the initiation of treatment and with dosage increment.
For the symptomatic relief of acute alcohol withdrawal:
- The following dosage schedule is recommended:
|1st 24 hours (Day 1)||30 mg initially; followed by 30 to 60 mg in divided doses|
|2nd 24 hours (Day 2)||45 to 90 mg in divided doses|
|3rd 24 hours (Day 3)||22.5 to 45 mg in divided doses|
|Day 4||15 to 30 mg in divided doses|
- Thereafter, gradually reduce the daily dose to 7.5 to 15 mg. Discontinue drug therapy as soon as patient's condition is stable.
- The maximum recommended total daily dose is 90 mg. Avoid excessive reductions in the total amount of drug administered on successive days.
As An Adjunct To Antiepileptic Drugs
- In order to minimize drowsiness, the recommended initial dosages and dosage increments should not be exceeded.
- The maximum recommended initial dose in patients over 12 years old is 7.5 mg three times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 90 mg/day.
Children (9-12 years)
- The maximum recommended initial dose is 7.5 mg two times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 60 mg/day.
What drugs interact with Tranxene?
- The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABAA sites and opioids interact primarily at mu receptors.
- When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation.
- If Tranxene is to be combined with other drugs acting on the central nervous system, careful consideration should be given to the pharmacology of the agents to be employed.
- Animal experience indicates that clorazepate dipotassium prolongs the sleeping time after hexobarbital or after ethyl alcohol, increases the inhibitory effects of chlorpromazine, but does not exhibit monoamine oxidase inhibition. Clinical studies have shown increased sedation with concurrent hypnotic medications. The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants.
- If Tranxene tablets are used to treat anxiety associated with somatic disease states, careful attention must be paid to possible drug interaction with concomitant medication.
- In bioavailability studies with normal subjects, the concurrent administration of antacids at therapeutic levels did not significantly influence the bioavailability of Tranxene tablets.
Is Tranxene safe to use while pregnant or breastfeeding?
- An increased risk of congenital malformations associated with the use of minor tranquilizers (chlordiazepoxide, diazepam, and meprobamate) during the first trimester of pregnancy has been suggested in several studies.
- Clorazepate dipotassium, a benzodiazepine derivative, has not been studied adequately to determine whether it, too, may be associated with an increased risk of fetal abnormality.
- Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.
- Patients should be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physician about the desirability of discontinuing the drug. Tranxene tablets should not be given to nursing mothers since it has been reported that nordiazepam is excreted in human breast milk.
Tranxene is a prescription medicine used to treat anxiety disorders, (with other medicines) to treat partial seizures, and to treat the symptoms of sudden alcohol withdrawal. The most common side effects of Tranxene include drowsiness, dizziness, upset stomach, blurred vision, and dry mouth.
Multimedia: Slideshows, Images & Quizzes
A Visual Guide to Generalized Anxiety Disorder
Learn about generalized anxiety disorder (GAD). See if your worries are normal or something more by learning about symptoms,...
Anxiety, Stress, Worry, and Your Body
What is the definition of anxiety, stress, and worry? Find treatments to relieve stress, eliminate worry, and combat anxiety as...
Anxiety & Panic Disorders: Risk Factors for Anxiety
Do you feel anxious? Many things could make it more likely. Learn more, including what you can do if you feel anxious.
Depression: Foods to Avoid If You Have Anxiety or Depression
Feeling a little jittery? It could be something you ate. Learn the foods to avoid if you're anxious or depressed.
Related Disease Conditions
Second Source article from WebMD
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
Seizures: Symptoms and Types
Seizures occur when there is an abnormal burst of electrical activity in the brain and are divided into two categories: generalized and partial. Learn about the symptoms of different types of seizures, and check out the center below for more medical references on seizures, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
What Happens During an Anxiety Attack?
Anxiety can occur during everyday life, it could be fleeting or it could persist and build. But if you have an anxiety disorder, you may feel your anxiety or panic overwhelm you with intense anxiety and fear.
Can the Vagus Nerve Cause Seizures?
The vagus nerve is an important pathway to the brain in addition to helping to control seizures. Stimulation of the vagus nerve leads to the discharge of electrical energy into a wide area of the brain, disturbing the abnormal brain activity that causes seizures. The vagus nerve is used to treat seizures that do not respond to medications.
Which Color Light Helps Anxiety?
Chromotherapy is an alternative medicine technique that claims to cure various physical or mental disorders by using colors. Most practitioners of modern medicine believe that this technique lacks scientific evidence.
Seizure vs. Seizure Disorders: What's the Difference?
Seizures and seizure disorders are not the same medical problems. A seizure happens when the electrical activity in the brain is uncontrolled. There are about 40 different types of seizure disorders, in which epilepsy is one. Symptoms depend on the type of disorder, but can include loss of consciousness, uncontrolled twitching or shaking of one side, or the entire body.
What Is a Cluster Seizure?
Cluster seizures are episodes of increased seizure activity in which two or more seizures occur in 24 hours. Multiple seizures occur one after the other typically with a recovery period between each seizure and are different from a person’s usual seizure pattern.
What Are the Six Types of Anxiety Disorders?
Anxiety disorders cause worry, fear and panic as an irrational response to mundane situations. The six main types are generalized anxiety disorder, panic disorder, social anxiety, separation anxiety, trauma-related disorders and phobias.
What Is the Difference Between a Panic Attack and an Anxiety Attack?
What is the difference between a panic attack and an anxiety attack? Learn about the differences between these common occurrences.
Holiday Depression, Anxiety, and Stress
Though the holidays are a fun time for most, for others, they're a sad, lonely and anxiety-filled time. Get tips on how to avoid depression and stress during the holiday season.
What Does Anxiety Do to Your Body?
It increases a person’s chances of suffering from other medical conditions, such as heart diseases, raised blood pressure, high cholesterol obesity, depression and diabetes. In short term, anxiety may cause sleep disturbances and poor work performance.
Is Valerian Root Good for Anxiety?
Valerian is an herb that has been used for many centuries to help relieve anxiety and as a sleep aid in traditional medicine. The studies for proving the effectiveness of valerian root for sleep and anxiety have not been conclusive. More studies are required to prove its effectiveness and find the optimal dose.
Is Trichotillomania an Anxiety Disorder?
Trichotillomania, also known as hair-pulling, is an impulse control disorder. It could be caused by anxiety and stress. It can coexist with an anxiety disorder. However, psychiatrists consider it as a separate illness and not an anxiety disorder.
What Are the Different Types of Seizures?
A seizure is a sudden change in the brain's normal electrical activity. During a seizure, brain cells fire uncontrollably than their normal rate, temporarily affecting the way a person behaves, moves, thinks, or feels. Recurrent seizures are called epilepsy. Seizures are usually categorized into three types depending on their onset.
How Do You Stop Multiple Seizures?
Seizures are a medical emergency. Whether the seizure is a first-time onset or a recurring episode, it is advisable to dial 911 and call for help. A group of drugs called benzodiazepines is usually administered to stop multiple seizures.
What Triggers Social Anxiety?
Social anxiety disorder, also known as social phobia, is a mental health condition that is characterized by extreme anxiety and fear of social settings. People with social anxiety disorder have a constant, intense, persistent fear of being watched, judged, negatively evaluated, or rejected in a social situation.
What Symptoms Are Caused by Anxiety?
It's normal to feel stressed or worried about things that happen in our everyday lives. However, people who experience anxiety disorders often feel heightened fear or worry about common situations.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.