Medical Definition of Transforming growth factor

Reviewed on 3/29/2021

Transforming growth factor: (TGF) One of several proteins secreted by transformed cells that can stimulate the growth of normal cells. Transforming growth factor alpha (TGF alpha or TGF-A) binds the epidermal growth factor receptor (EGFR) and stimulates the growth of endothelial cells (cells that line the inside of blood vessels). Transforming growth factor beta (TGF-beta or TGF-B) is found in hematopoietic (blood-forming) tissue and initiates a signaling pathway that suppresses the early development of cancer cells.

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