Medical Definition of Transaminase, serum glutamic pyruvic (SGPT)

Reviewed on 3/29/2021

Transaminase, serum glutamic pyruvic (SGPT): An enzyme that is normally present in liver and heart cells, and is released into blood when the liver or heart is damaged. Blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. Interpretation of elevated SGPT levels depends on the context, and can necessitate additional clinical and laboratory information.

Also known as alanine aminotransferase (ALT).

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