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- What is tranexamic acid (Lysteda), and how does it work (mechanism of action)?
- What are the uses for Lysteda?
- Lysteda Side effects
- What's the dosage for Lysteda, and how should I take it?
- Which drugs or supplements interact with this medication?
- What brand names are available for tranexamic acid?
- Is tranexamic acid available as a generic drug?
- Do I need a prescription for this drug?
- Is it safe to take Lysteda if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is tranexamic acid (Lysteda), and how does it work (mechanism of action)?
Tranexamic acid (Lysteda) promotes the clotting of blood and thereby reduces bleeding due to heavy menstruation.
Tranexamic acid is a man-made amino acid derivative that increases blood clotting by preventing the breakdown of fibrin. Fibrin is a protein and an important component of blood clots. It is broken down by another protein called plasmin. Tranexamic acid blocks the action of plasmin on fibrin and thereby prevents the breakdown of fibrin.This leads to stabilization and preservation of fibrin in blood clots, and this helps reduce bleeding during a heavy menstrual cycle.
The FDA approved tranexamic acid in November 2009.
What are the uses for Lysteda?
Lysteda Side effects
Side effects of this drug include:
- Abdominal and back pain
- Joint pain
- Muscle cramps and spasms
- Musculoskeletal pain
- Nasal and sinus problems
Tranexamic acid may increase the risk of forming blood clots.
What's the dosage for Lysteda, and how should I take it?
In females 12 years of age and older, the recommended dose is two 650 mg tablets (1300 mg) by mouth three times a day for a maximum of 5 days during the menstrual cycle. It may be administered without regard to meals. Tablets should be swallowed whole and not chewed or broken.
Safe and effective use of tranexamic acid is not determined in premenarcheal girls or girls under the age of 12.
Which drugs or supplements interact with this medication?
- Concomitant use of tranexamic acid and birth control medications can increase the risk of blood clots.
- Concomitant use with tissue plasminogen activators (used to prevent or treat blood clots) can reduce the effectiveness of tranexamic acid.
- Concomitant use with Factor IX complex concentrates or anti-inhibitor coagulant concentrates that promote blood clots is not recommended due to the increased risk of blood clots.
What brand names are available for tranexamic acid?
Lysteda is the brand name available in for tranexamic acid in the US.
Do I need a prescription for this drug?
Yes, you need a prescription from your doctor or other health care professional for Lysteda.
Is it safe to take Lysteda if I'm pregnant or breastfeeding?
- Tranexamic acid is not approved for use in pregnant women. Moreover, there no adequate studies of tranexamic acid to determine safe and effective use in pregnant women.
- Tranexamic acid is present in breast milk in trace amounts; therefore, caution must be exercised before considering itsuse in nursing mothers.
Lysteda (tranexamic acid) is a medication prescribed to promote blood clotting during menstruation, thus reducing bleeding due to heavy periods (menstruation). Non-FDA (off-label) uses are:
- Nosebleeds (epistaxis)
- Cone biopsy
- Hyphema (an eye condition)
- Hereditary angioedema (a condition that is similar to hives)
Side effects are anemia, joint pain, headache, fatigue, sinus or nasal problems, muscle spasms and cramps, abdominal pain, migraine, and back pain. Lysteda comes in tablets of 650 mg. It may interact with birth control medications, tissue plasminogen activators, and Factor IX complex concentrates. Lysteda is not approved for during pregnancy, and it is excreted in breast milk. Talk with your OB/GYN about taking this drug if you are pregnant or breastfeeding.
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REFERENCE: FDA Prescribing Information.