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- What is tranexamic acid (Lysteda), and how does it work (mechanism of action)?
- What are the uses for Lysteda?
- Lysteda Side effects
- What's the dosage for Lysteda, and how should I take it?
- Which drugs or supplements interact with this medication?
- What brand names are available for tranexamic acid?
- Is tranexamic acid available as a generic drug?
- Do I need a prescription for this drug?
- Is it safe to take Lysteda if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is tranexamic acid (Lysteda), and how does it work (mechanism of action)?
Tranexamic acid (Lysteda) promotes the clotting of blood and thereby reduces bleeding due to heavy menstruation.
Tranexamic acid is a man-made amino acid derivative that increases blood clotting by preventing the breakdown of fibrin. Fibrin is a protein and an important component of blood clots. It is broken down by another protein called plasmin. Tranexamic acid blocks the action of plasmin on fibrin and thereby prevents the breakdown of fibrin.This leads to stabilization and preservation of fibrin in blood clots, and this helps reduce bleeding during a heavy menstrual cycle.
The FDA approved tranexamic acid in November 2009.
What are the uses for Lysteda?
Lysteda Side effects
Side effects of this drug include:
- Abdominal and back pain
- Joint pain
- Muscle cramps and spasms
- Musculoskeletal pain
- Nasal and sinus problems
Tranexamic acid may increase the risk of forming blood clots.
What's the dosage for Lysteda, and how should I take it?
In females 12 years of age and older, the recommended dose is two 650 mg tablets (1300 mg) by mouth three times a day for a maximum of 5 days during the menstrual cycle. It may be administered without regard to meals. Tablets should be swallowed whole and not chewed or broken.
Safe and effective use of tranexamic acid is not determined in premenarcheal girls or girls under the age of 12.
Which drugs or supplements interact with this medication?
- Concomitant use of tranexamic acid and birth control medications can increase the risk of blood clots.
- Concomitant use with tissue plasminogen activators (used to prevent or treat blood clots) can reduce the effectiveness of tranexamic acid.
- Concomitant use with Factor IX complex concentrates or anti-inhibitor coagulant concentrates that promote blood clots is not recommended due to the increased risk of blood clots.
What brand names are available for tranexamic acid?
Lysteda is the brand name available in for tranexamic acid in the US.
Do I need a prescription for this drug?
Yes, you need a prescription from your doctor or other health care professional for Lysteda.
Is it safe to take Lysteda if I'm pregnant or breastfeeding?
- Tranexamic acid is not approved for use in pregnant women. Moreover, there no adequate studies of tranexamic acid to determine safe and effective use in pregnant women.
- Tranexamic acid is present in breast milk in trace amounts; therefore, caution must be exercised before considering itsuse in nursing mothers.
What else should I know about this drug?
What preparations of tranexamic acid (Lysteda) are available?
Tablets: 650 mg.
How should I keep tranexamic acid (Lysteda) stored?
Tranexamic acid tablets should be stored between 15 C to 30 C (59 F to 86 F).
Lysteda (tranexamic acid) is a medication prescribed to promote blood clotting during menstruation, thus reducing bleeding due to heavy periods (menstruation). Non-FDA (off-label) uses are:
- Nosebleeds (epistaxis)
- Cone biopsy
- Hyphema (an eye condition)
- Hereditary angioedema (a condition that is similar to hives)
Side effects are anemia, joint pain, headache, fatigue, sinus or nasal problems, muscle spasms and cramps, abdominal pain, migraine, and back pain. Lysteda comes in tablets of 650 mg. It may interact with birth control medications, tissue plasminogen activators, and Factor IX complex concentrates. Lysteda is not approved for during pregnancy, and it is excreted in breast milk. Talk with your OB/GYN about taking this drug if you are pregnant or breastfeeding.
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Related Disease Conditions
Hives, also called urticaria, is a raised, itchy area of skin that is usually a sign of an allergic reaction. The allergy may be to food or medications, but usually the cause of the allergy (the allergen) is unknown.
Normal vaginal bleeding (menorrhea) occurs through the process of menstruation. Abnormal vaginal bleeding in women who are ovulating regularly most commonly involves excessive, frequent, irregular, or decreased bleeding. Causes of abnormal may arise from a variety of conditions that may include, uterine fibroids, IUDs, hypothyroidism, hyperthyroidism, lupus, STDs, pelvic inflammatory disease, emotional stress, anorexia nervosa, polycystic ovary syndrome (PCOS), cancers, early pregnancy.
Nosebleeds are common in dry climates during winter months, and in hot dry climates with low humidity. People taking blood clotting medications, aspirin, or anti-inflammatory medications may be more prone to nosebleeds. Other factors that contribute to nosebleed are trauma (including nose picking, especially in children), rhinitis (both allergic and nonallergic), and high blood pressure. First-aid treatments for a nosebleed generally do not need medical care. Frequent or chronic nosebleeds may require medical treatment such as over-the-counter (OTC) medication, and prevention of nose picking.
Premenstrual Syndrome (PMS)
Premenstrual syndrome (PMS) is a combination of physical and emotional disturbances that occur after a woman ovulates and ends with menstruation. Common PMS symptoms include; depression, irritability, crying, oversensitivity, and mood swings. For some women PMS symptoms can be controlled with natural and home remedies, medications, and lifestyle changes such as exercise, nutrition, and a family and friend support system.
Menstruation (Menstrual Cycle)
Menstruation (menstrual cycle) is also referred to as a "period." When a woman menstruates, the lining of the uterus is shed. This shedding of the uterine linking is the menstrual blood flow. The average menstrual cycle is 28 days. There can be problems with a woman's period, including heavy bleeding, pain, or skipped periods. Causes of these problems may be amenorrhea (lack of a period), menstrual cramps (dysmenorrhea), or abnormal vaginal or uterine bleeding. There are a variety of situations in which a girl or woman should see a doctor about her menstrual cycle.
Premenstrual Dysphoric Disorder (PMDD)
Premenstrual dysphoric disorder (PMDD) is considered a severe form of premenstrual syndrome (PMS). PMDD has also been referred to as late luteal phase dysphoric disorder. The cause of PMDD is unknown. Some of the common symptoms of PMDD (not an inclusive list) include mood swings, bloating, fatigue, headache, irritability, headache, breast tenderness, acne, and hot flashes. Treatment for PMDD is with medication to treat the symptoms of PMDD.
Menstrual Cramps and PMS (Premenstrual Syndrome) Treatment
Menstrual cramps and premenstrual syndrome (PMS) symptoms include abdominal cramping, bloating, a feeling of fullness, abdominal pain, mood swings, anxiety and more. Treatment for menstrual cramps and premenstrual syndrome (PMS) symptoms include regular sleep, exercise, smoking cessation, diet changes, and OTC or prescription medication depending on the severity of the condition.
Menstrual cramps (pain in the belly and pelvic area) are experienced by women as a result of menses. Menstrual cramps are not the same as premenstrual syndrome (PMS). Menstrual cramps are common, and may be accompanied by headache, nausea, vomiting, constipation, or diarrhea. Severity of menstrual cramp pain varies from woman to woman. Treatment includes OTC or prescription pain relief medication.
Hereditary Angioedema (HAE)
Hereditary angioedema or HAE is a genetic disease that causes swelling of the skin and tissues beneath it. Symptoms of HAE include shortness of breath, mood changes, laryngeal edema (a medical emergency), swelling of the hands and feet, muscle aches, and skin tingling. Treatment of HAE includes medication and avoidance of triggers.
Are Hives (Urticaria) Contagious?
Hives are not contagious are triggered by an allergic response to a substance. Symptoms and signs of hives include a raised, itchy red rash on the skin. An individual should seek medical care for hives if he or she develops dysphagia, wheezing, shortness of breath, or throat tightening.
What Are the Types of Eye Care?
Many common eye disorders resolve without treatment and some may be managed with over-the-counter (OTC) products. It's important to visit a physician or ophthalmologist is the problem involves the eyeball itself or the condition hasn't improved after 72 hours of use of an OTC eye care product.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
REFERENCE: FDA Prescribing Information.