tranexamic acid (injection, Cyklokapron)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is tranexamic acid-injection, and how does it work (mechanism of action)?

  • Tranexamic acid promotes the clotting of blood and thereby reduces bleeding due to tooth extractions in people with hemophilia. People with hemophilia bleed easily because they lack a specific blood protein necessary for forming blood clots.
  • Tranexamic acid is a man-made amino acid derivative that increases blood clotting by preventing the breakdown of fibrin. Fibrin is a protein and an important component of blood clots. It is broken down by another protein called plasmin. Tranexamic acid blocks the action of plasmin on fibrin and thereby prevents the breakdown of fibrin. This leads to stabilization and preservation of fibrin in blood clots. This helps reduce bleeding after a tooth extraction.
  • The FDA approved tranexamic acid injection in December, 1986.

What brand names are available for tranexamic acid-injection?

Cyklokapron

Is tranexamic acid-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for tranexamic acid-injection?

Yes

What are the uses for tranexamic acid-injection?

Tranexamic acid injection is used short-term (two to eight days) to prevent bleeding following tooth extraction in people with hemophilia.

What are the side effects of tranexamic acid-injection?

Common side effects of tranexamic acid injection include:

Other less common side effects side effects include:

What is the dosage for tranexamic acid-injection?

  • Prior to tooth extraction, tranexamic acid should be administered at a dose of 10 mg per kg body weight of intravenously.
  • Thereafter, a dose of 10 mg per kg body weight should be given three to four times daily for 2 to 8 days after tooth extraction.

Which drugs or supplements interact with tranexamic acid-injection?

  • Concomitant use with tissue plasminogen activators (used to prevent or treat blood clots) can reduce the effectiveness of tranexamic acid.
  • Concomitant use with factor IX complex concentrates or anti-inhibitor coagulant concentrates that promote blood clots is not recommended due to the increased risk of blood clots.

Is tranexamic acid-injection safe to take if I'm pregnant or breastfeeding?

  • Tranexamic acid injection has not been adequately evaluated in pregnant women.
  • Tranexamic acid is present in breast milk in trace amounts; therefore, caution must be exercised when it is used in nursing mothers.

What else should I know about tranexamic acid-injection?

What preparations of tranexamic acid-injection are available?

Single dose injection (vials or ampules): 100 mg/ml

How should I keep tranexamic acid-injection stored?

Tranexamic acid injection should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

REFERENCE: FDA Prescribing Information

Summary

Tranexamic acid injection (Cyklokapron) is a prescription medication used to prevent bleeding after tooth extraction in individuals with hemophilia. Side effects, drug interactions, warnings, dosing, and pregnancy and breastfeeding information should be reviewed prior to using any medication.

Treatment & Diagnosis

Prevention & Wellness

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Reviewed on 4/15/2016
References
REFERENCE: FDA Prescribing Information

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