- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Brand Name: Ultracet
Drug Class: Opioid Agonists
What is tramadol and acetaminophen, and what is it used for?
Tramadol and acetaminophen each relieve pain, but they do so by different mechanisms. Tramadol achieves pain relief in two ways. It binds to the -opioid receptor on nerves (the same mechanism that is responsible for the effectiveness of narcotics, such as morphine), and it also inhibits the reuptake by nerves of two neurotransmitters, serotonin, and norepinephrine, that the nerves use to communicate with one another. This inhibition may lead to reduced transmission of pain signals from the nerve to nerve in the spinal cord and brain.
Acetaminophen achieves pain relief in the spinal cord and brain by increasing the threshold to pain, that is, by increasing the strength of the painful stimulus that is necessary in order to give rise to the sensation of pain. It does this by inhibiting an enzyme that makes prostaglandins. Ultracet was approved by the FDA in 2001.
What are the side effects of tramadol and acetaminophen?
Ultracet usually is well-tolerated. The most common side effects are:
Because tramadol is chemically related to the narcotic class of drugs such as morphine and hydrocodone (Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco), it can cause psychological or physical dependence. Some patients who received tramadol have reported seizures.
Abrupt withdrawal of tramadol may result in the following side effects:
An overdose of acetaminophen can result in severe liver damage.
What is the dosage for tramadol and acetaminophen?
- The usual dose of Ultracet is two tablets every four to six hours as needed for the relief of pain.
- Patients should not take more than two tablets at a time or more than 8 tablets per day.
Which drugs interact with tramadol and acetaminophen?
- Carbamazepine (Tegretol) or rifampin can increase the rate of metabolic breakdown of tramadol, thus making tramadol less effective.
- Concomitant administration of quinidine, fluoxetine (Prozac), paroxetine (Paxil) and amitriptyline (Elavil, Endep), ketoconazole (Nizoral, Extina, Xolegel, Kuric), or erythromycin may reduce the elimination of tramadol, increasing the risk for serious side effects from tramadol.
- Combining tramadol with monoamine oxidase inhibitors (for example, Parnate), selective serotonin inhibitors (SSRIs, for example, fluoxetine [Prozac]), linezolid (Zyvox), St. John's wort, triptans (for example sumatriptan [Imitrex, Alsuma]) may result in severe side effects such as seizures or a condition called serotonin syndrome.
- Tramadol may increase the central nervous system and respiratory depression when combined with alcohol, anesthetics, narcotics, tranquilizers, or sedative hypnotics.
- Scans Show Brain Changes in People With Long COVID
- Got GERD? Eat This Way to Help Avoid Symptoms
- 5 Women Contracted Syphilis Affecting the Eyes From the Same Asymptomatic Man
- Long COVID Now Common in U.S. Nursing Homes
- Breathing in Coal-Based Pollution Could Be Especially Deadly: Study
- More Health News »
Pregnancy and breastfeeding
What else should I know about tramadol and acetaminophen?
What preparations of tramadol and acetaminophen are available?
- Tablets: tramadol, 37.5 mg, and acetaminophen, 325 mg.
How should I keep tramadol and acetaminophen stored?
- Ultracet should be stored at room temperature, between 15 and 30 C (59-86 F). It should be kept out of the reach of children.
Ultracet is a combination of the drugs tramadol and acetaminophen. Ultracet is prescribed for the short-term relief of moderate to severe acute pain. Ultracet usually is well-tolerated. The most common side effects are constipation, tiredness, and increased sweating. Do not take tramadol and acetaminophen if pregnant and consult your doctor if breastfeeding.
Multimedia: Slideshows, Images & Quizzes
Pain Management: Signs Your Muscle Pain Is Something Else
Could your achy muscles be a sign of more than a tough workout? Learn when a twinge might warrant a visit to the doctor's office.
Pain Management: Surprising Causes of Pain
What's causing your pain? Learn the common causes of lower back pain, as well as pain in the knee, stomach, kidney, shoulder,...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive chronic pain...
Back Pain Quiz: Test Your Back Pain IQ
There are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge...
Fibromyalgia Quiz: What Is Fibromyalgia?
Fibromyalgia could be the reason for your constant, deep bodily pain. Learn more about this painful condition with the...
Pain Management: All About CBD Oil
Cannabidiol oil: It's made from marijuana and everyone seems to be talking about it. But what is it, and what does it really do?
Pain Management: One-Move Fixes for Pain and Stress
A quick stretch, yoga pose, or on-the-spot exercise can help fix sudden aches from head to toe. Learn how to quash pain with just...
Pain Management: Knee Pain Dos and Don'ts
Your knees go through a lot in the course of a day, and sometimes they can run into trouble. Here are a few things you can do...
Pain Management: Why Does My Calf Muscle Hurt?
There's a group of muscles on the back of each lower leg that doctors call "calf muscles." They play a key role in helping you...
Pain Management: Visual Guide to Frozen Shoulder
It's got nothing to do with cold weather. It means your shoulder is jammed up. WebMD guides you through the causes of frozen...
Pain Management: All About Your Knees
They do their job so well that you might take them for granted. Learn how they're put together, what can go wrong with them, and...
Pain Management: Why Knees Hurt
Your knees have lots of parts, and you use them a lot, so there's plenty that could go wrong. WebMD explains common things that...
Pain Management: Ergonomic Tips for a Home Office
Are you working at home? Find out how to set up a workspace to prevent stiffness, protect your muscles and joints, and avoid...
Related Disease Conditions
What Is the Strongest Painkiller?
The most powerful pain reliever is a class of medications known as “opioids,” which have a significant risk of addiction and dependency. These drugs are routinely recommended by doctors for severe pain treatment, as well as a variety of other illnesses.
Pain Management and Rheumatoid Arthritis
Second Source article from WebMD
Fibromyalgia is a chronic pain condition characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress reduction, exercise, and medication are the standard treatments for fibromyalgia.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
What Do You Do When Pain Management Doesn't Work?
If you suffer from chronic pain, it can be frustrating when your pain medications are no longer effective. Here is what you can do when pain management doesn’t work.
Pain Management: Neuropathic Pain
Neuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system (brain and spinal cord) or the peripheral nervous system (nerves outside the brain and spinal cord).
Treatment & Diagnosis
- Fibromyalgia FAQs
- Back Pain FAQs
- Pain Management: OTC NSAIDs - Doctors Dialogue
- Pain Management Over-The-Counter
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Doctors Answer Pain Questions
- When Should I Give a Child Tylenol for Fever?
- What Pain Medication Can I Take While on Warfarin?
- Does Pain Medication Affect Men and Women Differently?
- What Are the Side Effects of Acetaminophen?
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- acetaminophen - oral, Panadol, Tylenol
- tramadol/acetaminophen - oral, Ultracet
- tramadol - oral, Ultram
- butalbital/acetaminophen/caffeine (Esgic, Fioricet)
- Tramadol (Ultram) Side Effects
- Tylenol (acetaminophen) Side Effects, Warnings, and Interactions
- propoxyphene and acetaminophen (Darvocet)
- expectorant/decongestant/narcotic antitussive/acetaminophen-oral
- morphine high potency injection (Astramorph, Duramorph, Infumorph, AVINza)
- Ultram (tramadol) Side Effects, Warnings, and Interactions
- isometheptene, acetaminophen, dichloralphenazone - oral, Amidrine, Isocom, Midchlor, Mi
- Side Effects of Percocet (oxycodone/acetaminophen)
- acetaminophen/phenyltoloxamine-oral, Dologesic, Flextra-650, Novagesic, Rhinoflex, Staflex
- Side Effects of Ultracet (tramadol and acetaminophen)
- Side Effects of Vicodin (hydrocodone/acetaminophen)
- morphine extended-release capsule - oral, Avinza
- butalbital/acetaminophen - oral, Phrenilin
- salicylamide/acetaminophen/phenyltoloxamine - oral, Anabar, Dolorex, Lobac
- Pain Medications (Narcotics)
- Side Effects of Duramorph (morphine)
- acetaminophen rectal
- morphine sustained-action capsule - oral, Kadian
- pentazocine/acetaminophen - oral, Talacen
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information