- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is torsemide, and how does it work?
- What brand names are available for torsemide?
- Is it available as a generic drug?
- Do I need a prescription for it?
- What are the uses for torsemide?
- Torsemide side effects
- What dosages are available for torsemide, and how do I take it?
- Which drugs or supplements might cause interactions?
- Is torsemide safe to use during pregnancy or while breastfeeding?
- Storage and FDA approval
- Overdose information
What is torsemide, and how does it work?
Torsemide (Demadex) is a potent drug that's a diuretic (water pill). This medicine causes a profound increase in urine output (diuresis) by preventing the kidney from retaining water. Specifically, it blocks the reabsorption back into the blood of sodium and water that has been filtered out of the blood in the kidneys.
It is in a class of diuretic drugs called "loop" diuretics, which also includes the drugs furosemide (Lasix) and bumetanide (Bumex). Torsemide 10-20 mg is approximately equivalent to 1 mg of bumetanide and 40 mg of furosemide. The potent diuretic effect of torsemide can cause the loss of large amounts of body water leading to dehydration as well as the loss of electrolytes (for example, sodium, potassium, magnesium, and calcium). Therefore, careful medical supervision is necessary during treatment.
What are the uses for torsemide?
This drug is prescribed by doctors to treat several diseases and conditions.
- Torsemide (Demadex) is used for the medical treatment of edema (water retention) due to congestive heart failure, kidney disease, chronic kidney failure, or liver disease.
- It also is used alone or combined with other antihypertensive medications for the treatment of high blood pressure (hypertension).
Who shouldn't take Demadex?
- Patient's shouldn't take Demadex if they are allergic to it or to sulfonylureas to which it is related.
- Don't take it if you aren't able to urinate.
- Patients with liver disease with cirrhosis and ascites should use this drug with caution because sudden changes in fluid and electrolyte balance can cause hepatic coma.
Torsemide side effects
- Dry mouth
- Reduced kidney function
- Heart arrhythmias
- Muscle aches and pains
Possible side effects of this medication reported often include:
- Excessive urination
- Runny nose
- ECG abnormality
- Joint pain
- Stomach upset
- Sore throat
- Muscle pain
Possible serious side effects adverse effects include:
- Atrial fibrillation
- Chest pain
- Gastrointestinal bleeding
- High blood sugar (hyperglycemia)
- Increased uric acid (hyperuricemia)
- Low blood potassium (hypokalemia)
- Low blood pressure (hypotension)
- Dehydration (symptoms listed previously)
- Shunt thrombosis
- Rectal bleeding
- Ventricular tachycardia
- Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- Allergic reactions
- Reduced number of white blood cells and platelets
Demadex can cause dehydration and loss of potassium and other electrolytes. Low potassium levels (hypokalemia) can cause abnormal heart beats especially in people with heart disease or those taking the medicine digoxin (Lanoxin). Levels of potassium and other electrolytes should be monitored during medical treatment with this medicine.
What dosages are available for torsemide, and how do I take it?
- Torsimide (Demadex) comes in tablets of 5, 10, 20, and 100 mg. The 10 mg/ml injectable solution has been discontinued.
- Patients can take the tablets at any time without regard to meals. (You can take it on an empty stomach.)
- For the treatment for patients with heart failure the initial dose is 10 to 20 mg by mouth or injection once daily. The dose may be doubled until the desired diuretic effect is achieved. The maximum dose is 200 mg daily.
- Chronic kidney failure is treated with 20 to 200 mg orally or by injection once daily.
- The dose for treating high blood pressure is 2.5 to 10 mg orally once daily.
- Liver cirrhosis is treated with 5 to 40 mg orally or by injection once daily. It is combined with aldosterone antagonists or potassium-sparing diuretics.
Which drugs or supplements might cause interactions?
Several medicines may cause interactions with torsemide.
- Torsemide can cause low blood potassium, calcium, and magnesium levels. These changes can increase the risk of toxicity from digoxin (Lanoxin). Combining torsemide with other diuretics such as metolazone (Zaroxolyn), hydrochlorothiazide, or chlorthalidone (Hygroton) can exaggerate the losses of potassium and magnesium.
- The body's ability to eliminate lithium (Lithobid, Eskalith) may decrease in patients receiving torsemide. Therefore, careful monitoring of lithium levels in blood is recommended when torsemide and lithium are taken together in order to prevent increases in lithium levels and lithium toxicity.
- Indomethacin (Indocin) can reduce the diuretic and blood pressure-lowering effects of other loop diuretics (for example furosemide) and it probably can do the same with torsemide. Other nonsteroidal anti-inflammatory drugs, for example, ibuprofen (Motrin), naproxen (Naprosyn) may interact similarly.
- Concomitant use of torsemide and aminoglycosides may increase the risk of hearing impairment since both agents can affect hearing.
- Probenecid decreases the diuretic effect of torsemide by reducing secretion of torsemide into the kidney tubules.
Heart Health Resources
Is torsemide safe to use during pregnancy or while breastfeeding?
- Researches, doctors, and other health care professionals haven't established the safety of Demadex in pregnant women.
- It's also not known whether it's excreted in human milk.
There have been no human experiences with overdoses of this medication. Signs and symptoms of overdose may include:
- Low blood pressure (hypotension)
- Hypokalemia (low potassium levels)
- Hypochloremic alkalosis
If you think someone has taken an overdose of this drug call 911 or the poison control center at 1-800-222-1222.
Torsemide (Demadex) is a prescription drug used to treat:
Side effects may include:
Multimedia: Slideshows, Images & Quizzes
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Atrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment
Atrial fibrillation is the most common type of abnormal heart rhythm. Atrial fibrillation or AF can lead to serious heart...
Atrial Fibrillation (A-Fib) Quiz: Test Your Medical IQ
Learn the causes, symptoms, and treatments of the common heart abnormality known as atrial fibrillation (A-fib)....
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Kidney Disease Quiz: Test Your Medical IQ
Kidney disease is common. Take this kidney disease quiz to test your knowledge and learn the symptoms, causes and types of kidney...
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function....
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Liver
Front View of the Liver. The liver is a large, meaty organ that sits on the right side of the belly. See a picture of the Liver...
Picture of Kidneys
The kidneys are a pair of organs located in the back of the abdomen. See a picture of the Kidneys and learn more about the health...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
Lower Your Cholesterol, Save Your Heart
Need to lower your cholesterol levels? Use these smart diet tips to quickly and easily lower your blood cholesterol levels....
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
Kidney Failure (Symptoms, Signs, Stages, Causes, Treatment, and Life Expectancy)
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss,...
Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral...
12 Congestive Heart Failure Symptoms, Stages, Causes, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There...
Stroke (Signs, Symptoms, Warning Signs)
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding...
Liver Disease Symptoms, Signs, Treatment, and Life Expectancy
Liver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high...
Liver cancer is cancer of the liver cells (hepatocellular carcinoma) or of the ducts in the liver (cholangiocarcinoma). Liver...
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation,...
Tylenol Liver Damage
Tylenol liver damage (acetaminophen) can occur from accidentally ingesting too much acetaminophen, or intentionally. Signs and...
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart...
Drug-Induced Liver Disease
Drug-induced liver diseases are diseases of the liver that are caused by: physician-prescribed medications, OTC...
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and...
Fatty Liver (NASH)
Nonalcoholic fatty liver disease or NASH occurs due to the accumulation of abnormal amounts of fat within the liver. Fatty liver...
Inherited Liver Diseases
Second Source WebMD Medical Reference...
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Lung Anatomy (Structure and Function)
The lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood....
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease)....
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Daily Health News
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.