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- Is tolazamide-oral available as a generic drug?
- Do I need a prescription for tolazamide-oral?
- What are the uses for tolazamide-oral?
- What are the side effects of tolazamide-oral?
- What is the dosage for tolazamide-oral?
- Which drugs or supplements interact with tolazamide-oral?
- What else should I know about tolazamide-oral?
What are the uses for tolazamide-oral?
- Tolazamide is used with diet and exercise to reduce blood glucose levels in adult patients with type 2 diabetes mellitus.
What are the side effects of tolazamide-oral?
Side effects associated with tolazamide therapy include:
- Dizziness
- Fatigue
- Headache
- Malaise
- Vertigo
- Increase sensitivity to the sunlight (photophobia),
- Itching
- Rash
- Hives
- Anorexia
- Constipation
- Diarrhea
- Sensations of stomach fullness
- Heartburn
- Nausea
- Vomiting
- Muscle weakness
- Water loss from the body (diuresis)
Possible serious side effects of tolazamide include:
- Disulfiram (Antabuse)-like reactions (for example, severe flushing accompanied by low blood pressure (hypotension) and tachycardia
- Low blood glucose
- Low blood sodium
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Blood disorders
- Liver dysfunction
What is the dosage for tolazamide-oral?
Adults
- Generally, patients are started on 100 to 250 mg of tolazamide once daily with breakfast or first meal of the day.
- Start with 100 mg/day for fasting blood sugar <200 mg/dL or 250 mg for fasting blood sugar >200 mg/dL.
- Use 100 mg/day for patients who are malnourished, underweight, elderly, or those not eating properly.
- Dosage may be increased by 100-250 mg at weekly intervals.
- The maximum daily dose is 500 mg orally twice daily (1000mg/day).
The safety and efficacy of tolazamide has not been established in pediatric patients. No specific dose adjustments are recommended in patients with kidney or liver disease.
Which drugs or supplements interact with tolazamide-oral?
- Coadministration of tolazamide with quinolone antibiotics may cause abnormal changes in blood glucose. Therefore, blood glucose must be closely monitored if these agents must be used together.
- Tolazamide may increase blood levels of methotrexate (Rheumatrex, Trexall) by interfering with the binding of methotrexate to blood proteins.
- Anti-retroviral protease inhibitors, a type of anti-HIV medication, may decrease the effectiveness of tolazamide and consequently worsen blood glucose control.
What else should I know about tolazamide-oral?
What preparations of tolazamide-oral are available?
Oral tablets: 100, 250, and 500 mg
How should I keep tolazamide-oral stored?
Tablets should be stored at room temperature, between 15 C and 30 C (59 F to 86 F).
SLIDESHOW
Type 2 Diabetes Diagnosis, Treatment, Medication See SlideshowSummary
Tolazamide (Tolinase brand has been discontinued.) is a drug prescribed to reduce glucose in people with type 2 diabetes. Tolinase is combined with exercise and diet. Side effects include:
Drug interactions, storage, dosing, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
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