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- Is tolazamide-oral available as a generic drug?
- Do I need a prescription for tolazamide-oral?
- What are the uses for tolazamide-oral?
- What are the side effects of tolazamide-oral?
- What is the dosage for tolazamide-oral?
- Which drugs or supplements interact with tolazamide-oral?
- What else should I know about tolazamide-oral?
What are the uses for tolazamide-oral?
What are the side effects of tolazamide-oral?
Side effects associated with tolazamide therapy include:
- Increase sensitivity to the sunlight (photophobia),
- Sensations of stomach fullness
- Muscle weakness
- Water loss from the body (diuresis)
Possible serious side effects of tolazamide include:
What is the dosage for tolazamide-oral?
- Generally, patients are started on 100 to 250 mg of tolazamide once daily with breakfast or first meal of the day.
- Start with 100 mg/day for fasting blood sugar <200 mg/dL or 250 mg for fasting blood sugar >200 mg/dL.
- Use 100 mg/day for patients who are malnourished, underweight, elderly, or those not eating properly.
- Dosage may be increased by 100-250 mg at weekly intervals.
- The maximum daily dose is 500 mg orally twice daily (1000mg/day).
The safety and efficacy of tolazamide has not been established in pediatric patients. No specific dose adjustments are recommended in patients with kidney or liver disease.
Which drugs or supplements interact with tolazamide-oral?
- Coadministration of tolazamide with quinolone antibiotics may cause abnormal changes in blood glucose. Therefore, blood glucose must be closely monitored if these agents must be used together.
- Tolazamide may increase blood levels of methotrexate (Rheumatrex, Trexall) by interfering with the binding of methotrexate to blood proteins.
- Anti-retroviral protease inhibitors, a type of anti-HIV medication, may decrease the effectiveness of tolazamide and consequently worsen blood glucose control.
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