- What is tobramycin and dexamethasone? How does it work (mechanism of action)?
- What are Tobradex used for?
- What are the side effects of tobramycin and dexamethasone?
- What is the dosage for tobramycin and dexamethasone?
- Is tobramycin and dexamethasone safe to take if you are pregnant or breastfeeding?
- What else should you know about tobramycin and dexamethasone?
What is tobramycin and dexamethasone? How does it work (mechanism of action)?
TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension 0.3%/0.05%) ophthalmic suspension is indicated for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.
Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies.
The use of a combination drug with an anti-infective component is indicated where the risk of superficial ocular infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
The particular anti-infective drug in this product is active against the following common bacterial eye pathogens: Staphylococci, including S. aureus and S. epidermidis (coagulase-positive and coagulase-negative), including penicillin-resistant isolates. Streptococci, including some Group A and other beta-hemolytic species, some nonhemolytic species, and some Streptococcus pneumoniae. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii , most Proteus vulgaris isolates, Haemophilus influenzae , H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species.
The brand name for tobramycin and dexamethasone ophthalmic suspension is TOBRADEX®.
TOBRADEX® is not available in generic form. You need a prescription to obtain TOBRADEX®.
What are Tobradex used for?
Tobradex (tobramycin) and dexamethasone ophthalmic suspension) is indicated for steroid responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exist
What are the side effects of tobramycin and dexamethasone?
The most frequently reported side effects of Tobradex are:
- swelling of the eye lids, and
- redness of the conjunctivae.
Other side effects include:
What is the dosage for tobramycin and dexamethasone?
The recommended dose is one or two drops (solution or ointment) or one drop (suspension) into the conjunctival sac every four to six hours. The dosing interval may be reduced to every two hours during the initial 24 to 48 hours. The hands should be washed before each use of Tobradex or any eye medication. The head is tilted back, and the lower eye lid is pulled down with the index finger to form a pouch. The tip of the dropper should not touch the eye or eyelid. The bottle of Tobradex should be squeezed slightly to allow the prescribed number of drops (generally one or two drops) into the pouch. If the ointment is being used, a small strip (about 1cm or 1/2 inch) of ointment should be squeezed into the pouch. The eye should then be closed gently for one to two minutes without blinking.
- U.S. States With Tighter Access to Welfare Payments Have More Kids in Foster Care
- 1 in 10 Teens Have Sexted, Many See Porn by 6th Grade: Study
- Eating Lots of 'Ultra-Processed' Foods Could Harm Your Brain
- Record Number of Fatal Drug ODs for Pregnant, Postpartum Women
- Concerns Around Sex, Fertility Often Ignored in Breast Cancer Care: Survey
- More Health News »
Is tobramycin and dexamethasone safe to take if you are pregnant or breastfeeding?
- Although no human studies have assessed the effects of Tobradex on the fetus, animal studies have shown adverse fetal effects. Physicians should prescribe it to women who are pregnant only if its benefits are deemed to outweigh the potential risks.
- It is not known if Tobradex is excreted into breast milk.
What else should you know about tobramycin and dexamethasone?
What preparations of tobramycin and dexamethasone are available?
- Ophthalmic solution or ointment: 0.3% tobramycin and 0.1% dexamethasone.
- Opthalmic Suspension: 0.3% tobramycin and 0.05% dexamethasone.
How should I keep tobramycin and dexamethasone stored?
TOBRADEX should be kept at room temperature, 15-30 C (59-86 F), and protected from direct light.
Tobramycin and dexamethasone (Tobradex, Tobradex ST) is a medication prescribed for the treatment of steroid responsive ocular inflammation that requires steroid treatment, and is caused by a bacterial infection, or if there is a risk of infection. Side effects, drug interactions, and dosage information should be reviewed prior to taking this medication.
Related Disease Conditions
Pink Eye (Conjunctivitis)
Pinkeye, also called conjunctivitis, is redness or irritation of the conjunctivae, the membranes on the inner part of the eyelids and the membranes covering the whites of the eyes. These membranes react to a wide range of bacteria, viruses, allergy-provoking agents, irritants, and toxic agents.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Treatment & Diagnosis
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information.