tobramycin ophthalmic solution

Tobramycin is an aminoglycoside antibiotic that interferes with bacterial production of proteins, ultimately leading to bacterial death. Tobramycin, like other aminoglycoside antibiotics, targets various gram-positive and gram-negative bacteria. Targeted organisms include Staphylococcus aureus, Staphylococcus epidermidis, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, Proteus vulgaris (most strains), Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, and some Neisseria species. The FDA approved tobramycin ophthalmic solution in December 1980.

Tobrex

GENERIC AVAILABLE: Yes

Yes

Side effects are rare. Less than 1% report sensitivity reactions including swelling and itching of the eyelid, and reddening of the eye (conjunctiva).

The initial dose for adults and children two months old or greater is 1 to 2 drops every 2 to 4 hours in the infected eye. For severe infections, up to 2 drops every hour may be used until improvement is seen, at which time the dose should be reduced.

There are no known drug interactions with tobramycin ophthalmic solution.

There is no evidence of harm to the fetus in animal studies with systemic tobramycin use; no direct studies in humans have been conducted. Blood levels are undetectable after ophthalmic tobramycin use.

Tobramycin ophthalmic solution is not absorbed into the body at detectable levels, and therefore not expected to be present in the breast milk. However, breast feeding is not recommended due to the potential for adverse effects in the infant.

What preparations of tobramycin-ophthalmic ointment are available?

Ophthalmic Solution 0.3%

How should I keep tobramycin-ophthalmic ointment stored?

Tobramycin ophthalmic solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Some preparations may be refrigerated and stored between 2 C to 8 C (36 F to 46 F).