tobramycin optic (Tobrex)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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What is tobramcyin-ophthalmic drops, and how does it work (mechanism of action)?

Tobramycin (Tobrex) is an antibiotic eye drop. Tobramycin is an aminoglycoside antibiotic that kills susceptible bacteria by blocking bacterial protein synthesis. Death of susceptible bacteria occurs because of the lack of functional proteins. Tobramycin treats only bacterial eye infections and does not work for other types of eye infections.

The FDA approved tobramycin eye drops in December 1980. In addition to eye drops, tobramycin is also available as 0.3% ointment which is also used to treat external bacterial infections of the eye.

What brand names are available for tobramcyin-ophthalmic drops?

Tobrex

Is tobramcyin-ophthalmic drops available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for tobramcyin-ophthalmic drops?

Yes

What are the side effects of tobramcyin-ophthalmic drops?

Side effects associated with the use of tobramycin eye drops are mostly limited to the area(s) of application. Reported side effects include:

  • tearing,
  • swelling of the eye, and
  • itching, stinging, or burning of the eye.

Administration of eye drops may cause temporary vision problems including blurred vision. Patients should not engage in dangerous activities such as driving until their vision improves.

Although serious allergic reactions to tobramycin are unlikely, patient suspected of experiencing such a reaction must seek emergency medical help. Symptoms of a serious allergic reaction may include:

  • difficulty breathing,
  • swelling of the tongue,
  • face, or throat, and
  • severe rash.

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What is the dosage for tobramcyin-ophthalmic drops?

For all patients ≥ 2 months of age: Instill 1-2 drops into the infected eye every 4 to 6 hours. For severe infections, instill 2 drops into the infected eye every 30 minutes to an hour until improvement and then reduce to less frequent dosing intervals as indicated. Patients using tobramycin ophthalmic solution:

  • should wash their hands thoroughly with soap and water before and after using eye drops;
  • should be advised not to wear contact lenses during treatment of active eye infections;
  • must take care to avoid touching the dropper tip to the eye while administrating eye drops;
  • should wait for at least 5 minutes between applications if other eye drop preparations also are used.

Which drugs or supplements interact with tobramcyin-ophthalmic drops?

: Information on possible drug interactions with tobramycin ophthalmic drops is not found. However, as use of therapeutic levels of tobramycin eye drops does not result into clinically meaningful levels of drug in the blood, the potential for drug interaction with other agents is relatively low. Patients using other eye drops or those with pre-existing conditions of the eye should check with their doctor or pharmacists before using tobramycin ophthalmic drops.

Is tobramcyin-ophthalmic drops safe to take if I'm pregnant or breastfeeding?

Most aminoglycoside antibiotics are excreted into breast milk in low concentrations. The risk for adverse effects in the nursing infant with use of ophthalmic tobramycin is considered to be low. However, consideration of the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated infection should all be taken into account when making the decision to use tobramycin ophthalmic in nursing mothers.

What else should I know about tobramcyin-ophthalmic drops?

What preparations of tobramcyin-ophthalmic drops are available?

0.3% ophthalmic solution (eye drops or ointment)

How should I keep tobramcyin-ophthalmic drops stored?

Tobramycin ophthalmic solution should be stored at room temperature between 20 C and 25 (68 F and 77 F).

REFERENCE: FDA Prescribing Information.

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Summary

Tobramycin optic (Tobrex) is a prescription antibiotic used to treat external infections of the eye caused by bacteria. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is included.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

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Reviewed on 6/9/2015
References
REFERENCE: FDA Prescribing Information.

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