- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: tizanidine
Brand Name: Zanaflex
Drug Class: Alpha2 Adrenergic Agonists
What is tizanidine, and what is it used for?
Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation.
The FDA approved tizanidine in November 1996.
What is the dosage for tizanidine?
- Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours.
- Increase by 2 to 4 mg until satisfactory response is achieved; however, the maximum dose is 36 mg per day.
Which drugs interact with tizanidine?
Tizanidine should not be used with:
- ciprofloxacin (Cipro),
- amiodarone (Cordarone),
- cimetidine (Tagamet),
- oral contraceptives,
- acyclovir (Zovirax), and
- fluvoxamine (Luvox).
These medications can slow down the breakdown of tizanidine and lead to increased sedation, drowsiness and slowed reflexes.
Tizanidine should be used with caution with medications like:
- alprazolam (Xanax),
- clonazepam (Klonopin),
- diazepam (Valium),
- zolpidem (Ambien),
- oxycodone (Roxicodone),
- hydromorphone (Dilaudid),
- amitriptyline (Elavil),
- nortriptyline (Pamelor) and
These medications can further increase the side effects of tizanidine.
Is tizanidine safe to take if I'm pregnant or breastfeeding?
What else should I know about tizanidine?
What preparations of tizanidine are available?
What preparations of tizanidine are available?
- Capsules: 2, 4, 6 mg; Tablets: 2, 4 mg
How should I keep tizanidine stored?
- Store tizanidine tablets and capsules between temperatures of 15 C – 30 C (59 F – 86 F).
Tizanidine is a drug used to treat the tendency of muscles to spasm, typically resulting from neurological problems. Common side effects of tizanidine include low blood pressure, dry mouth, dizziness, sleepiness, weakness, fatigue, blurred vision, and constipation. Consult your doctor if pregnant or breastfeeding.
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Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing strenuous exercise in a hot environment, prolonged muscle use, and certain diseases of the nervous system may cause muscle spasms. Symptoms and signs of a muscle spasm include an acute onset of pain and a possible bulge seen or felt beneath the skin where the muscle is located. Gently stretching the muscle usually resolves a muscle spasm.
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Multiple sclerosis or MS is an autoimmune disorder in which brain and spinal cord nerve cells become demyelinated. This damage results in symptoms that may include numbness, weakness, vertigo, paralysis, and involuntary muscle contractions. Different forms of MS can follow variable courses from relatively benign to life-threatening. MS is treated with disease-modifying therapies. Some MS symptoms can be treated with medications.
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