- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: tizanidine
Brand Name: Zanaflex
Drug Class: Alpha2 Adrenergic Agonists
What is tizanidine, and what is it used for?
Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation.
The FDA approved tizanidine in November 1996.
What is the dosage for tizanidine?
- Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours.
- Increase by 2 to 4 mg until satisfactory response is achieved; however, the maximum dose is 36 mg per day.
Which drugs interact with tizanidine?
Tizanidine should not be used with:
- ciprofloxacin (Cipro),
- amiodarone (Cordarone),
- cimetidine (Tagamet),
- oral contraceptives,
- acyclovir (Zovirax), and
- fluvoxamine (Luvox).
These medications can slow down the breakdown of tizanidine and lead to increased sedation, drowsiness and slowed reflexes.
Tizanidine should be used with caution with medications like:
- alprazolam (Xanax),
- clonazepam (Klonopin),
- diazepam (Valium),
- zolpidem (Ambien),
- oxycodone (Roxicodone),
- hydromorphone (Dilaudid),
- amitriptyline (Elavil),
- nortriptyline (Pamelor) and
These medications can further increase the side effects of tizanidine.
Is tizanidine safe to take if I'm pregnant or breastfeeding?
What else should I know about tizanidine?
What preparations of tizanidine are available?
What preparations of tizanidine are available?
- Capsules: 2, 4, 6 mg; Tablets: 2, 4 mg
How should I keep tizanidine stored?
- Store tizanidine tablets and capsules between temperatures of 15 C – 30 C (59 F – 86 F).
- Shingles Ups Odds of Stroke, Heart Attack By Almost 30%
- 'How Can I Prevent Heart Disease?' Docs Give Different Answers to Men, Women
- 'COVID-somnia' May Be Easing as Americans Report Better Sleep
- Bacteria Risk Spurs Recall of 8 Million Laundress Products
- U.S. to End Mpox Public Health Emergency in January
- More Health News »
Tizanidine is a drug used to treat the tendency of muscles to spasm, typically resulting from neurological problems. Common side effects of tizanidine include low blood pressure, dry mouth, dizziness, sleepiness, weakness, fatigue, blurred vision, and constipation. Consult your doctor if pregnant or breastfeeding.
Multimedia: Slideshows, Images & Quizzes
What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis
MS is an autoimmune disease that attacks the nerves of the central nervous system. Learn about multiple sclerosis (MS) causes,...
Muscle Cramps (Charley Horse) and Muscle Spasms
What are the differences between muscle spasms and cramps? Learn about the causes of muscle spasms and cramps (charley horse) in...
Celebrities With Multiple Sclerosis (MS)
Learn about celebrities, such as Montel Williams and Jack Osbourne, who are living with multiple sclerosis.
Multiple Sclerosis (MS) Quiz: Test Your Medical IQ
Multiple Sclerosis is a debilitating neurological condition. Take the MS Quiz to test your knowledge of the causes, symptoms,...
Multiple Sclerosis: Signs of Multiple Sclerosis Relapse
Signs of an MS relapse can vary in type and intensity. This WebMD slideshow lists some of the more common relapse symptoms.
Picture of Multiple Sclerosis Symptoms
Symptoms of multiple sclerosis may be single or multiple and may range from mild to severe in intensity and short to long in...
Multiple Sclerosis: Making an MS Friendly Home
Adults with multiple sclerosis may be at risk for injuries, hazards, and falling at home. Some simple home modifications can...
Neck Pain: Causes of Stiffness, Muscle Spasms, Treatment, and Relief
What causes chronic neck pain? If you have poor posture, bad sleep habits, or spine problems, these issues can lead to a stiff...
Related Disease Conditions
Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing strenuous exercise in a hot environment, prolonged muscle use, and certain diseases of the nervous system may cause muscle spasms. Symptoms and signs of a muscle spasm include an acute onset of pain and a possible bulge seen or felt beneath the skin where the muscle is located. Gently stretching the muscle usually resolves a muscle spasm.
Multiple Sclerosis (MS)
Multiple sclerosis or MS is an autoimmune disorder in which brain and spinal cord nerve cells become demyelinated. This damage results in symptoms that may include numbness, weakness, vertigo, paralysis, and involuntary muscle contractions. Different forms of MS can follow variable courses from relatively benign to life-threatening. MS is treated with disease-modifying therapies. Some MS symptoms can be treated with medications.
MS (Multiple Sclerosis) vs. ALS (Amyotrophic Lateral Sclerosis)
ALS (amyotrophic lateral sclerosis, Lou Gehrig's disease) and MS (multiple sclerosis) are both diseases of the nervous system (neurodegenerative). ALS is a disease in which the nerve cells in the body are attacked by the immune system, although it's not considered an autoimmune disease by some scientists. MS is an autoimmune disease in which the insulated covering of the nerves (myelin sheath) in the CNS (central nervous system) degenerate, or deteriorate. Scientists don't know the exact cause of either problem. However, they have discovered that mutations in the gene that produces the SOD1 enzyme were associated with some cases of familial ALS. Scientists also theorize that multiple sclerosis may be caused by infection or vitamin D deficiency. ALS occurs between 50-70 years of age (the average age of occurrence ALS is 55), and mostly affects men. While MS occurs between 20-60 years of age, and mostly affects women. About 30,000 people in the US have ALS, and an average of 5,000 new diagnoses per year (that's about 15 new cases per week). Worldwide, MS affects more than 2.3 million people, with about 10,000 new cases diagnosed each year (that's about 200 new diagnoses per week).Some of the signs and symptoms of both diseases include muscle weakness, muscle spasms, problems walking, fatigue, slurred speech, and problems swallowing. ALS signs and symptoms that are different from MS include problems holding the head upright, clumsiness, muscle cramps and twitches, problems holding objects, and uncontrollable periods of laughing or crying. MS signs and symptoms that are different from ALS include vision problems, vertigo and balance problems, sexual problems, memory problems, depression, mood swings, and digestive problems. There is no cure for either disease, however the prognosis and life expectancy are different. Multiple sclerosis is not a fatal condition, while ALS progresses rapidly and leads to death.
Types of Traumatic Brain Injury (TBI) Medications
Traumatic brain injury and related conditions, may require diuretics, anticonvulsants, sedatives, antidepressants, muscle relaxers, pain relievers, and stimulants to treat deficits in cognitive functions such as attention, memory, learning and language.
Multiple Sclerosis (MS) Symptoms and Treatments
Multiple sclerosis (MS) symptoms vary from person to person and can last for days to months without periods of remission. Symptoms of MS include sexual problems and problems with the bowel, bladder, eyes, muscles, speech, swallowing, brain, and nervous system. The early symptoms and signs of multiple sclerosis usually start between ages 20-40. MS in children, teens, and those over age 40 is rare. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.
Spinal Cord Injury: Treatments and Rehabilitation
When vertebrae are broken or dislocated, the result can cause traumatic injury to the spinal cord. A spinal cord injury can have significant physiological consequences. One indication of the severity of a spinal cord injury are respiratory complications. Spinal cord injuries are classified as either. Rehabilitation and recovery of a spinal cord injury is dependant upon the type of injury.
Is Multiple Sclerosis (MS) Contagious?
Multiple sclerosis, or MS, is a degenerative disease of the covering around the nerves in the central nervous system (CNS). Researchers and doctors don't know the exact cause, but many theorize that it may be due to environmental triggers, an autoimmune disease, and viruses (infections). Symptoms and signs of MS include vision changes, paralysis, vertigo, heat intolerance, slurred speech, sexual dysfunction, and urinary incontinence (the inability to urinate). There's no vaccine or cure for MS, but the progression and symptoms of the disease can be treated.
Multiple Sclerosis (MS) and Pregnancy
Multiple sclerosis or MS is a central nervous system disease in which the immune system attacks the myelin sheath (the protective coating around nerves). Symptoms of MS include pain, sexual problems, fatigue, numbness and tingling, emotional changes, and depression.Women who are pregnant and have multiple sclerosis may have more difficulty carrying a pregnancy. Multiple sclerosis does not affect ability to conceive, and does not seem to affect fertility. MS symptoms during pregnancy may stay the same or get better; however, they may worsen after giving birth. Pregnancy decreases the number of relapses, but flares increase in the first 3-6 months after delivery. Pregnant women with MS may carrying a pregnancy more difficult to tell when labor starts, and there is an increased need to use forceps or vacuum to assist with delivery or b7 C-section (Cesarean birth) increases. Some treatment MS drugs may be safe to use during pregnancy; however, some drugs should not be taken, for example, baclofen (Gablofen, Lioresal), fluoxetine (Prozac, Sarafem), or solifenacin succinate (VESIcare), and most disease-modifying therapies (DMTs). Talk with your healthcare team about vitamins, supplements, and medications that you are taking if you are pregnant and have MS.
Multiple Sclerosis (MS) Early Warning Signs and Types
Multiple sclerosis (MS) can be thought of as an immune-mediated inflammatory process involving different areas of the central nervous system (CNS) at various points in time. Early warning signs and symptoms of MS in children, teens, and adults are similar; however, children and teens with pediatric also may have seizures and a complete lack of energy. Adults with MS do not have these signs and symptoms. Other signs and symptoms of MS include inflammation of the optic nerve (optic neuritis), changes in vision, Wiping or having tissues around the eye and moving the eye may be painful, and double vision. There are four types of MS, relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and progressive relapsing MD (PRMS).
Can Stress Cause Multiple Sclerosis (MS)?
Multiple sclerosis (MS) results when your immune system attacks the cells of the brain and spinal cord. It is an autoimmune disease, a condition in which the body's immune system is misdirected and attacks its own cells. Stress can make it difficult for a person to manage MS symptoms. Regular exercise and mindful eating have been found to control the stress levels and overall health of people with MS.
Early Signs of Multiple Sclerosis
Multiple sclerosis (MS) is a progressive disease of the brain and spinal cord (central nervous system). MS is an autoimmune disease; the body’s immune system mistakenly attacks the cells of the nervous system.
What Are the Very First Signs of Multiple Sclerosis?
Multiple sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease that affects the brain and spinal cord of the central nervous system (CNS). MS is one of the most common causes of non-injurious disability in young and middle-aged adults.
Alternative Treatment (CAM) for MS
The term alternative therapy, in general, is used to describe any medical treatment or intervention that has not been scientifically documented or identified as safe or effective for a specific condition. Alternative therapy encompasses a variety of disciplines that range from diet and exercise to mental conditioning to lifestyle changes.
What Is Relapsing-Remitting Multiple Sclerosis?
The relapsing-remitting form of multiple sclerosis is characterized by clearly defined bouts of new or increased neurologic symptoms. After an attack, you will go through a period of healing called remission, during which you will have a few to no symptoms.
Does Alcohol Mess With Multiple Sclerosis?
Studies suggest that consuming alcohol may worsen some symptoms of multiple sclerosis.
What Is the Best Treatment for Spinal Cord Injury?
Immediate spinal cord injury (SCI) treatment can help avert worse consequences and is usually considered the best treatment option for SCI.
What Is the Difference Between Clinically Isolated Syndrome and Multiple Sclerosis?
Clinically isolated syndrome (CIS) is often considered as a phenotype or phase of multiple sclerosis (MS). The clinical symptoms of both CIS and MS look identical; however, they differ in the following ways.
What Is Sclerosis in Multiple Sclerosis?
The medical term sclerosis refers to abnormal hardening of body tissue. In multiple sclerosis, there is a development of hard areas called "plaques" along a neuron's axon (part of a nerve cell).
What Is the Main Cause of Multiple Sclerosis?
According to numerous studies, multiple sclerosis (MS) is a multifactorial disease with autoimmune, genetic, and environmental triggers. Learn nine potential triggers for MS.
What Are the Subtypes of Multiple Sclerosis (MS)?
Multiple sclerosis (MS) is a disease that affects the body's nervous system. There are six distinct forms of MS, with symptoms ranging from mild to severe.
What Are the Phenotypes of Multiple Sclerosis (MS)?
Phenotypes can be useful for clinical diagnosis by characterizing the most typical patterns of progression identified in MS patients. Learn about the four basic phenotypes of MS.
What Are the Early Signs of Multiple Sclerosis?
Multiple sclerosis is an autoimmune disease in which the immune system attacks the central nervous system (spinal cord and brain) by damaging and destroying the protective myelin sheath around the nerve fibers. Someone with multiple sclerosis might develop problems with muscle control, vision, bladder control and other body functions.
Treatment & Diagnosis
- Multiple Sclerosis MS FAQs
- Spinal Cord Injury: C4 Is a Crucial Level
- Medication Disposal
- Dangers of Mixing Medications
- Multiple Sclerosis: New Multiple Sclerosis Treatment Suspended
- Drugs: Buying Prescription Drugs Online Safely
- Progressive Muscle Relaxation
- Drugs: The Most Common Medication Errors
- Multiple Sclerosis: New Treatment Possibility for MS
- How Serious Is Multiple Sclerosis?
- What Causes Rectal Muscle Spasms?
- How Does Multiple Sclerosis Affect the Body?
- Multiple Sclerosis Treatment
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information