Opium tincture is an oral liquid medication used to control diarrhea. Opium tincture contains morphine which is an opioid pain reliever. Opioids can reduce gastrointestinal motility, propulsion, secretions, and increase gastrointestinal muscle tone. These effects help in controlling diarrhea. Opium tincture is a controlled substance.

N/A

GENERIC AVAILABLE: Yes

Yes

Side effects of opium tincture are:

• sedation,
• constipation,
• nausea,
• vomiting,
• itching, and
• rash.

Respiratory depression and physical and psychological dependence also occur.

• Adults: Take 0.6 ml by mouth 4 times a day not to exceed 6 ml per day.
• Children: Safe and effective use of opium tincture is not established in children.

Opium tincture should not be used with medications like naltrexone and buprenorphine because they increase sedation and lower beneficial effect of opium tincture.

Opium tincture contains morphine. Morphine should be avoided in patients treated with monoamine oxidase inhibitors (MAOI) due to enhance toxicity of morphine including confusion, high blood pressure, tremor, hyperactivity, coma, and death. Drugs in this class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), and linezolid (Zyvox). Morphine should not be administered within 14 days of stopping an MAOI.

There are no adequate studies done on opium tincture to determine safe and effective use in pregnant women.

Opium tincture contains morphine. Morphine is excreted in breast milk; however, the American Academy of Pediatrics committee states that it is safe to use while breastfeeding.

What preparations of tincture of opium-oral liquid are available?

Opium tincture is odorless oral liquid containing 10 mg of anhydrous morphine per one ml.

How should I keep tincture of opium-oral liquid stored?

Store tincture of opium at room temperature between 68 F to 77 F (20 C to 25 C).