GENERIC NAME: TILUDRONATE - ORAL (till-EW-dro-nate)
BRAND NAME(S): Skelid
USES: Tiludronate is used to treat a certain type of bone disease called Paget's disease. This disease weakens and deforms bones. Tiludronate works by slowing bone loss, helping to keep your bones strong and less likely to break. It also helps reduce bone pain from this disease. This medication belongs to a class of drugs known as bisphosphonates.
HOW TO USE: Follow these instructions very closely to make sure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth without food as directed by your doctor, usually once a day. The dosage is based on your medical condition and response to treatment. Take it on an empty stomach at least 2 hours before or 2 hours after a meal.Take tiludronate with a full glass of plain water (6 to 8 ounces/180 to 240 milliliters). Do not take it with any other beverage, including mineral water. After taking tiludronate, stay fully upright (sitting, standing, or walking) and do not lie down for at least 30 minutes.Do not take tiludronate at the same time as food or other medications because they may affect its absorption. Take this medication 2 hours before or 2 hours after taking any products that contain aluminum, calcium, iron, magnesium, or zinc. Some examples include certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice.If you take antacids that contain aluminum or magnesium, take them at least 2 hours after taking tiludronate.If you take aspirin or indomethacin, take the dose 2 hours before or 2 hours after your tiludronate dose.Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day as directed by your doctor, usually for 3 months.
SIDE EFFECTS: Nausea, vomiting, diarrhea, gas, or runny nose may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: new or worsening bone/joint/muscle pain, new or unusual hip/thigh/groin pain, jaw pain, eye/vision problems.This medication may infrequently cause irritation and ulcers in your stomach or esophagus. Get medical help right away if any of these serious side effects occur: new/severe/worsening heartburn, chest pain, difficult/painful swallowing, stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking tiludronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate, etidronate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, inability to sit upright or stand for at least 30 minutes, difficult/painful swallowing, esophagus problems (such as heartburn, narrowing of the esophagus), stomach/intestinal problems (such as ulcers), low level of calcium in the blood.Infrequently, people taking this class of medication (bisphosphonates) have had serious jawbone problems (osteonecrosis). Lack of proper dental hygiene, poorly fitting dentures, or certain dental procedures (such as tooth extraction, dental surgery) may increase your risk. Medical conditions (such as gum disease/infection, cancer, anemia) might also increase the risk. If you develop jaw pain, tell your doctor and dentist immediately.Before having surgery (especially dental procedures), tell your doctor and dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking tiludronate before your surgery. Ask for specific instructions about stopping or starting this medication.Caution is advised if you are pregnant or planning to become pregnant in the future. This medication may stay in your body for many years. Its effects on an unborn baby are not known. Discuss the risks and benefits with your doctor before starting treatment with this medication.It is unknown if this drug passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
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DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.Eat well-balanced meals that contain adequate calcium and vitamin D. You may also need to take calcium and vitamin D supplements. Consult your doctor for specific advice.Laboratory and/or medical tests (such as X-rays, height, blood mineral levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, take it as soon as you remember, following the dose-timing instructions in the How to Use section. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Do not remove the tablets from the packaging until you are ready to use them. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.
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