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- What is tigecycline, and how does it work (mechanism of action)?
- What are the side effects of tigecycline?
- What is the dosage for tigecycline?
- Which drugs or supplements interact with tigecycline?
- Is tigecycline safe to take if I'm pregnant or breastfeeding?
- What else should I know about tigecycline?
What is tigecycline, and how does it work (mechanism of action)?
Tigecycline is an injectable antibiotic used for the treatment of infections caused by susceptible bacteria. Tigecycline is similar to tetracycline antibiotics and has activity against a large number of bacteria. Tigecycline binds to bacterial ribosomes which produce the cell's proteins. The binding prevents bacterial ribosomes from producing important proteins needed for bacterial growth and multiplication. Tigecycline prevents bacteria from multiplying, but it does not kill bacteria. Tigecycline was approved by the FDA in June 2005.
What brand names are available for tigecycline?
Is tigecycline available as a generic drug?
Do I need a prescription for tigecycline?
What are the side effects of tigecycline?
Other side effects include:
- pain at the injection site;
- swelling and irritation;
- increased or decreased heart rate; and
Tigecycline is similar to tetracycline antibiotics and therefore may have similar side effects such as increased sensitivity to sunlight. Tigecycline may cause permanent discoloration of teeth if used during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years). Like other antibiotics, tygecycline can alter normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting tigecycline (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
What is the dosage for tigecycline?
Tigecycline is administered via intravenous infusions over 30-60 minutes. The initial dose is 100 mg followed by 50 mg every 12 hours. The usual duration of treatment is 5-14 days for complicated skin infections or for complicated intra-abdominal infections, and 7-14 days for community-acquired bacterial pneumonia.
Which drugs or supplements interact with tigecycline?
Tigecycline may decrease the elimination of the blood thinner warfarin (Coumadin) thereby increasing warfarin levels in blood. Therefore, there is a potential for tigecycline to increase the effects of warfarin and promote bleeding. Any effect on warfarin and the potential increased risk of bleeding should be monitored by tests of bleeding.
Is tigecycline safe to take if I'm pregnant or breastfeeding?
Administration of tigecycline to pregnant women may cause harm to the fetus, and use during tooth development may cause permanent discoloration of teeth.
What else should I know about tigecycline?
What preparations of tigecycline are available?
Single dose vial: 50 mg
How should I keep tigecycline stored?
The powder should be stored at room temperature between 15 C - 30 C (59 F - 86 F). Once mixed, it may be stored at room temperature for up to 24 hours (up to six hours in the vial and the remaining time in the intravenous bag). It may also be refrigerated at 2 C - 8 C (36 F - 46 F) for up to 48 hours in an intravenous bag after mixing.
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Tigecycline (Tygacil) is an antibiotic used to treat complicated skin infections caused by susceptable strains of bacteria, for treating complicated intra-abdominal infections caused by susceptible strains of bacteria, and to treat community-aquired bacterial pneumonia. Side effects, dosage, drug interactions, and patient safety information should be reviewed prior to taking this medication.
Related Disease Conditions
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
CRE Bacteria Infection
Carbapenem-resistant Enterobacteriaceae (CRE) is a type of bacteria that is highly resistant to antibiotics. Escherichia coli (E. coli) and Klebsiella are common types of Enterobacteriaceae that can be found in the human intestines. However, these bacteria can cause infections if they escape the intestines. Carbapenems are broad-spectrum antibiotics that treat infections caused by bacteria that are highly resistant to other types of antibiotics.
NDM-1 (New Delhi metallo-beta-lactamase) is an enzyme produced by certain strains of bacteria that have recently acquired the genetic ability to make this compound. Bacteria that produce NDM-1 are resistant to all commonly used beta-lactam antibiotics. Klebsiella, Escherichia and Acinetobacter are known to possess the gene for NDM-1, which can turn these bacteria into superbugs. Symptoms and signs of NDM-1 infection include fever, fatigue, and shock. Treatment depends upon the NDM-1 strain.
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