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- What is thioridazine- oral, and how does it work (mechanism of action)?
- Is thioridazine- oral available as a generic drug?
- Do I need a prescription for thioridazine- oral?
- What are the side effects of thioridazine- oral?
- What is the dosage for thioridazine- oral?
- Which drugs or supplements interact with thioridazine- oral?
- Is thioridazine- oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about thioridazine- oral?
What is thioridazine- oral, and how does it work (mechanism of action)?
Thioridazine is an oral antipsychotic medication used for the management of schizophrenia. Thioridazine is one of the older, first-generation antipsychotic medications. Examples of other first-generation antipsychotics include:
- prochlorperazine (Compazine, Compro, Procomp)
- chlorpromazine (Promapar, Thorazine)
- perphenazine (Trilafon)
- trifluoperazine (Stelazine)
Although the exact mechanism of antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Thioridazine is used when patients do not respond to other antipsychotics.
What are the side effects of thioridazine- oral?
Thioridazine causes extrapyramidal side effects such as:
- Abnormal muscle contractions
- Difficulty breathing and swallowing
- Neck spasms
Other side effects include:
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
What is the dosage for thioridazine- oral?
- The recommended starting dose of thioridazine for treating schizophrenia is 50 to 100 mg every 8 hours.
- Maintenance is recommended with doses every 6-12 hours with a total daily dose of 200 to 800 mg.
- The dose for treating depressive disorders is 25 mg every 8 hours. The dose may be increased slowly to 20 to 200 mg daily.
Which drugs or supplements interact with thioridazine- oral?
Combining thioridazine with medications such as procainamide (Pronestyl), sotalol (Betapace), amiodarone (Cordarone), and dofetilide (Tikosyn) that affect heart rate and rhythm can cause abnormal heart beats.
Antidepressants such as fluoxetine (Prozac), sertraline (Zoloft) and tricyclic antidepressants may reduce the breakdown of thioridazine, leading to increased blood levels and side effects of thioridazine.
Thioridazine should be used with caution with medications that depress the central nervous system and cause sedation or drowsiness. Examples include alprazolam (Xanax), clonazepam (Klonopin), zolpidem (Ambien), codeine, morphine, and alcohol. Such combinations can cause excessive sedation, drowsiness, weakness, confusion, speech impairment, and in severe cases coma or death. Combining alcohol with thioridazine also increases the risk of low blood pressure.
Is thioridazine- oral safe to take if I'm pregnant or breastfeeding?
Use of thioridazine during pregnancy has not been adequately studied. Infants exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder.
Safe use of thioridazine by nursing mothers has not been established.
What else should I know about thioridazine- oral?
What preparations of thioridazine- oral are available?
Tablets: 10, 25, 50 and 100 mg.
How should I keep thioridazine- oral stored?
Thioridazine tablets should be stored between 15 C and 30 C (59 F and 86 F).
REFERENCE: FDA Prescribing Information.
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Anticholinergic or antispasmodic (generic name) drugs include prescription medications used to treat a variety of medical conditions like:
- muscle spasms,
- breathing problems,
- movement disorders,
- motion sickness,
- and gastrointestinal cramps.
Examples of anticholinergic (antispasmodic) drugs include:
- Parkinson's disease medications,
- Benadryl, antipsychotics,
- and Levsin.
Examples of anticholinergic drugs for overactive bladder include:
- and Sanctura.
Examples of anticholinergic antidepressant medications include:
- and Norpranmin.
Examples of anticholinergic muscle relaxants include:
- and Norflex.
Anticholinergic motion sickness medications include:
- and respiratory medications.
Anticholinergic drug side effects, drug interactions, storage, dosing, and pregnancy and safety information should be reviewed prior to taking any medication.
Brief Psychotic DisorderBrief psychotic disorder is a short-term mental illness that features psychotic symptoms. There are three forms of brief psychotic disorder. The first occurs shortly after a major stress, the second has no apparent trauma that triggers the illness, and the third is associated with postpartum onset. Symptoms include hallucinations, delusions, unusual behavior, disorientation, changes in eating and sleeping, and speech that doesn't make sense. Treatment typically involves medication and psychotherapy.
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perphenazinePerphenazine (Trilafon - discontinued) is a prescription drug used to manage schizophrenia, severe nausea and vomiting in adults, and hiccups that last longer than a month. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information is provided.
Depression Physical SymptomsDepression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Learn the signs of depression that show up in the body.
Schizoaffective DisorderSchizoaffective disorder is a mental illness that features schizophrenia and a mood disorder, either major depression or bipolar disorder. Symptoms include agitation, suicidal thoughts, little need for sleep, delusions, hallucinations, and poor motivation. Treatment may involve psychotherapy, medication, skills training, or hospitalization.
SchizophreniaSchizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to communicate and pay attention. Symptoms of psychosis appear in men in their late teens and early 20s and in women in their mid-20s to early 30s. With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.
Schizophrenia SlideshowWhat is schizophrenia? Learn about schizophrenia symptoms, signs, and treatment. Read about schizophrenia types such as paranoid schizophrenia, catatonic schizophrenia, and disorganized schizophrenia.
Schizophrenia QuizSchizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz.
Schizotypal Personality DisorderSchizotypal personality disorder is characterized by odd behaviors, feelings, perceptions, and ways of relating to others that interfere with one's ability to function. Medication and psychotherapy can help the sufferer to manage their symptoms.