- What is testosterone topical solution (Axiron), and how does it work (mechanism of action)?
- What brand names are available for testosterone topical solution (Axiron)?
- Is testosterone topical solution (Axiron) available as a generic drug?
- Do I need a prescription for testosterone topical solution (Axiron)?
- What are the side effects of testosterone topical solution (Axiron)?
- What is the dosage for testosterone topical solution (Axiron)?
- Is testosterone topical solution (Axiron) safe to take if I'm pregnant or breastfeeding?
- What else should I know about testosterone topical solution (Axiron)?
What is testosterone topical solution (Axiron), and how does it work (mechanism of action)?
Axiron is a solution of testosterone that is administered through the skin of the armpit for treatment of low testosterone levels. It belongs to a class of drugs called androgens. Other testosterone replacement products include Androderm, Androgel, Testim, and Fortesta. Testosterone is the major male sex hormone responsible for the normal growth and development of the male sex organs and secondary sex characteristics. These effects include development of the prostate, penis and scrotum; distribution of facial, pubic, chest and axillary hair; development of a deep voice and alterations in muscle mass and fat distribution. Low production of testosterone leads to erectile dysfunction, reduced sexual desire, fatigue and loss of energy, depression, regression of secondary sexual characteristics and weakening of bones (osteoporosis). Testosterone replacement products supplement or replace natural production of testosterone and reverse symptoms of low testosterone levels. The FDA approved Axiron in November 2010.
What are the side effects of testosterone topical solution (Axiron)?
The most common side effects are application site reactions such as itching, blisters, and redness.
Other side effects include:
- headache,
- diarrhea,
- vomiting,
- acne, enlarged breasts,
- high blood pressure,
- mood swings,
- nervousness,
- changes in libido,
- increased serum prostate specific antigen (PSA) levels, and
- increased volume of red blood cells.
Other important side effects include:
- Reduced sperm production,
- prolonged painful erection,
- enlarged prostate,
- depression, and
- worsening of heart failure also occur.
Quick GuideLow Testosterone (Low T) Treatments
What is the dosage for testosterone topical solution (Axiron)?
The recommended dose is 30 to 120 mg daily once every morning at approximately the same time. The starting dose is 30 mg (1 pump actuation) applied to each armpit (60 mg total). The total daily dose may be decreased to 30 mg or increased to 90 mg (3 pump actuations) or from 90 to 120 mg (4 pump actuations) based on blood testosterone levels. Hands should be washed thoroughly with soap and water after applying Axiron.
Is testosterone topical solution (Axiron) safe to take if I'm pregnant or breastfeeding?
Axiron should not be used during pregnancy because testosterone is harmful to the fetus.
Axiron should not be used by nursing mothers because of the possibility of adverse effects in the nursing infant.
What else should I know about testosterone topical solution (Axiron)?
What preparations of testosterone topical solution (Axiron) are available?
PREPARATIONS: Solution: 2% (30 mg/1.5 ml actuation)
How should I keep testosterone topical solution (Axiron) stored?
Axiron should be stored at room temperature 15 C to 30 C (59 F to 86 F)
Summary
Testosterone topical solution (Axiron) is a testosterone solution that is administered through the skin of the armpit to treat low levels of testosterone. Side effects, drug interactions, and patient safety information should be reviewed prior to taking this medication.
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Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Depression
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).Depression in the Elderly
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