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What is teriparatide, and how does it work (mechanism of action)?
- Teriparatide (Forteo) is a prescription medicine used to treat osteoporosis, a bone disease that over time causes bones to become fragile and more likely to break. Teriparatide is similar to human parathyroid hormone (PTH) and is made using recombinant DNA (rDNA) technology. PTH is naturally produced by the body and is the key regulator of calcium and phosphate metabolism in the bone and kidney. Calcium and phosphate are the main minerals necessary for bone health. PTH also increases the absorption of calcium in the intestines. Teriparatide binds to the same receptors as natural PTH and mimics the favorable effects of PTH on bone health. Beneficial effects of teriparatide in osteoporosis treatment include reduced bone turnover, formation of new bone, and increased bone mineral density and bone strength.
- Teriparatide was first approved by the FDA in 2002.
What brand names are available for teriparatide?
Is teriparatide available as a generic drug?
Do I need a prescription for teriparatide?
What are the uses for teriparatide?
Forteo is a prescription medicine that is used to treat:
What are the side effects of teriparatide?
The most common side effects of Forteo are
In animal studies some rats developed osteosarcoma, a type of bone cancer. Osteosarcoma is a rare but serious form of cancer rarely reported in patients taking Forteo. To investigate if Forteo increases the risk of osteosarcoma, a voluntary patient registry has been developed. Patients can get more information about this registry by calling 1-866-382-6813 or visiting www.forteoregistry.rti.org.
Possible serious side effects or adverse events:
- Patients with Paget's disease of bone, pediatric and young adult patients with open epiphyses (ends of long bones that are still growing), and patients with prior external beam or implant radiation involving the skeleton should not receive Forteo.
- Forteo should not be used for more than 2 years in a patient's lifetime and should not be given to patients with bone cancer, history of skeletal cancer, metabolic bone diseases other than osteoporosis, or hypercalcemic disorders.
- Forteo may increase blood levels of calcium and uric acid. It may also increase calcium levels in urine.
What is the dosage for teriparatide?
- The recommended dose for all FDA approved indications is 20 mcg subcutaneously once a day. F
- Forteo should be administered subcutaneously in either the thigh or stomach area.
- Forteo pens are preset to deliver 20 mcg of medicine with each injection.
- The safety and effectiveness of Forteo injection has not been studied beyond 2 years of treatment.
Which drugs or supplements interact with teriparatide?
- Forteo injection should be used cautiously in patients taking digoxin (Lanoxin), a medication used to treat irregular heart rhythms. Forteo increases calcium in the blood and high levels of calcium may increase the risk for digoxin associated side effects.
- Forteo injection should be used cautiously with other medicines that may increase calcium in the blood.
What else should I know about teriparatide?
What preparations of teriparatide-injection are available?
Prefilled multi-dose pen containing 600 mcg/2.4ml. Each dose is 20 mcg.
How should I keep teriparatide-injection stored?
- Forteo injection should be stored in the refrigerator between 2 C to 8 C (36 F to 4 F).
- Pens should be removed from the refrigerator only when ready to use and returned to the refrigerator right after use. Forteo injection should not be stored in the freezer.
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Forteo (teriparatide) is a drug prescribed to treat osteoporosis. Common side effects include joint pain, joint aches, and nausea. Drug interactions, storage, dosing, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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Related Disease Conditions
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
A broken bone is a fracture. There are different types of fractures, such as: compressed, open, stress, greenstick, spiral, vertebral compression, compound, and comminuted. Symptoms of a broken bone include pain at the site of injury, swelling, and bruising around the area of injury. Treatment of a fracture depends on the type and location of the injury.
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies, and should be discussed with your physician.
Osteopenia is a bone condition characterized by bone loss that is not as severe as in osteoporosis. Bone fracture is the typical symptom of osteopenia, though the condition may be present without symptoms. Treatment involves lifestyle modifications (quitting smoking, not drinking in excess) and ensuring an adequate intake of vitamin D and calcium.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.