ombitasvir, paritaprevir and ritonavir

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is Technivie, and how does it work (mechanism of action)?

: Technivie is a combination oral medication containing ombitasvir, paritaprevir, and ritonavir. Technivie is used with ribavirin (Rebetol) to treat genotype 4 hepatitis C virus (HCV) infections in patients without liver cirrhosis. Technivie belongs to a class of drugs called direct-acting antiviral agents. Similar drugs include

Ombitasvir and paritaprevir are antivirals that have direct activity against HCV. They block the effect of proteases which are enzymes that HCV uses for making new viruses, leading to reduced numbers of HCV copies in the body. Ombitasvir blocks HCV NS5A protease while paritaprevir blocks HCV NS3/4A protease. The third medicine in Technivie, ritonavir, is not active against the HCV virus. It is used to increase blood levels of paritaprevir by inhibiting the breakdown of paritaprevir.

The combination of Technivie and ribavirin for 12 weeks resulted in 100% cure rates in patients with genotype 4 chronic HCV without cirrhosis. Cure was defined as undetectable levels of HCV in the body 3 months after treatment had ended. The FDA approved Technivie in July 2015.

What brand names are available for Technivie?


Is Technivie available as a generic drug?


Do I need a prescription for Technivie?


What are the side effects of Technivie?


  • Technivie may cause an abnormal increase in liver enzymes, especially in females taking ethinyl estradiol-containing medications such as combined oral contraceptives or contraceptive patches or contraceptive vaginal rings. Ethinyl estradiol-containing medications must be stopped before starting treatment with Technivie.
  • Warnings and precautions for ribavirin should be followed because it is used in combination with Technivie.
  • Ritonavir, a component of Technivie is an HIV protease inhibitor used to treat HIV infections. Any person infected with both HCV and HIV and are treated with Technivie should also receive antiretroviral HIV treatment to reduce the risk of HIV drug resistance.

What is the dosage for Technivie?

  • The recommended dose of Technivie is two tablets by mouth once daily with the morning meal. Technivie is used in combination with another HCV medication called ribavirin. The dosage of ribavirin is based on weight and usually is administered twice daily with food. Adults with genotype 4 infection without cirrhosis should receive 12 weeks of Technivie plus ribavirin.
  • Alternatively, some patients who are unable to tolerate ribavirin may be treated with Technivie alone for 12 weeks.
  • Technivie is not recommended for patients with moderate or severe liver disease.

Which drugs or supplements interact with Technivie?

Technivie interacts with many drugs. The prescribing information should be consulted for a complete list of drugs that interact with Technivie. Technivie should not be used with the following medications:

Is Technivie safe to take if I'm pregnant or breastfeeding?

Although no fetal adverse events were reported in animal studies, adequate and well-controlled studies of Technivie treatment in pregnant women are lacking. Therefore, Technivie should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

However, when Technivie is administered with ribavirin, the combination regimen should not be used in pregnant women and in men who can father children. Ribavirin is known to cause birth defects and should be avoided during pregnancy.

It is not known whether Technivie is excreted into human milk. Due to the lack of conclusive safety data, Technivie should be used cautiously in nursing mothers.

What else should I know about Technivie?

What preparations of Technivie are available?

Oral tablets each containing 12.5 mg ombitasvir, 75 mg paritaprevir, and 50 mg ritonavir.

How should I keep Technivie stored?

Technivie tablets should be stored at room temperature, between 15 and 30 C (59 F and 86 F).


Technivie (ombitasvir, paritaprevir and ritonavir) is a combination drug prescribed to treat heptatitis C in patients without liver cirrhosis. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication

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REFERENCE: FDA Prescribing Information