- What is Technivie, and how does it work (mechanism of action)?
- What brand names are available for Technivie?
- Is Technivie available as a generic drug?
- Do I need a prescription for Technivie?
- What are the side effects of Technivie?
- What is the dosage for Technivie?
- Which drugs or supplements interact with Technivie?
- Is Technivie safe to take if I'm pregnant or breastfeeding?
- What else should I know about Technivie?
What is Technivie, and how does it work (mechanism of action)?
: Technivie is a combination oral medication containing ombitasvir, paritaprevir, and ritonavir. Technivie is used with ribavirin (Rebetol) to treat genotype 4 hepatitis C virus (HCV) infections in patients without liver cirrhosis. Technivie belongs to a class of drugs called direct-acting antiviral agents. Similar drugs include
- boceprevir (Victrelis),
- sofosbuvir (Sovaldi),
- simeprevir (Olysio),
- telaprevir (Incivek), and
- ombitasvir, paritaprevir, ritonavir, and dasabuvir (Viekira Pak).
Ombitasvir and paritaprevir are antivirals that have direct activity against HCV. They block the effect of proteases which are enzymes that HCV uses for making new viruses, leading to reduced numbers of HCV copies in the body. Ombitasvir blocks HCV NS5A protease while paritaprevir blocks HCV NS3/4A protease. The third medicine in Technivie, ritonavir, is not active against the HCV virus. It is used to increase blood levels of paritaprevir by inhibiting the breakdown of paritaprevir.
The combination of Technivie and ribavirin for 12 weeks resulted in 100% cure rates in patients with genotype 4 chronic HCV without cirrhosis. Cure was defined as undetectable levels of HCV in the body 3 months after treatment had ended. The FDA approved Technivie in July 2015.
What are the side effects of Technivie?
- Technivie may cause an abnormal increase in liver enzymes, especially in females taking ethinyl estradiol-containing medications such as combined oral contraceptives or contraceptive patches or contraceptive vaginal rings. Ethinyl estradiol-containing medications must be stopped before starting treatment with Technivie.
- Warnings and precautions for ribavirin should be followed because it is used in combination with Technivie.
- Ritonavir, a component of Technivie is an HIV protease inhibitor used to treat HIV infections. Any person infected with both HCV and HIV and are treated with Technivie should also receive antiretroviral HIV treatment to reduce the risk of HIV drug resistance.
What is the dosage for Technivie?
- The recommended dose of Technivie is two tablets by mouth once daily with the morning meal. Technivie is used in combination with another HCV medication called ribavirin. The dosage of ribavirin is based on weight and usually is administered twice daily with food. Adults with genotype 4 infection without cirrhosis should receive 12 weeks of Technivie plus ribavirin.
- Alternatively, some patients who are unable to tolerate ribavirin may be treated with Technivie alone for 12 weeks.
- Technivie is not recommended for patients with moderate or severe liver disease.
Which drugs or supplements interact with Technivie?
Technivie interacts with many drugs. The prescribing information should be consulted for a complete list of drugs that interact with Technivie. Technivie should not be used with the following medications:
- Afluzosin hydrochloride (Uroxatral), a medicine used to treat benign prostate hyperplasia (BPH), due to the risk of hypotension (low blood pressure).
- Certain anti-seizure medications, including carbamazepine (Tegretol), phenytoin (Dilantin), and phenobarbital (Luminal), which may decrease the blood concentrations of Technivie and reduce the effectiveness of treatment.
- Rifampin (Rifadin, Rimactane), a component of many regimens for treating tuberculosis, which may decrease the blood concentrations of Technivie, reducing the effectiveness of treatment.
- Ergot derivatives which are used to treat migraine headaches should not be used with Technivie due to the risk of ergot toxicity.
- Combination birth control pills that contain ethinyl estradiol should be avoided due to the potential for liver damage.
- St. John's Wort may decrease the blood concentrations of Technivie, resulting in reduced effectiveness of treatment.
- Commonly used cholesterol lowering agents, lovastatin (Mevacor) and simvastatin (Zocor), should be avoided due to the risk for serious muscle pain and injury, including rhabdomyolysis.
- Combining Technivie and pimozide (Orap) may increase the risk for abnormal heart beats.
- Combining efavirenz (Sustiva) and Technivie may increase the risk of liver damage.
- Combining Technivie with sildenafil (Viagra, Revatio) and similar drugs may increase the risk of vision problems, low blood pressure, fainting, and priapism (painful, long lasting erection).
- Technivie increases blood levels of triazolam (Halcion) and midazolam, leading to increased sedation and respiratory depression.
Is Technivie safe to take if I'm pregnant or breastfeeding?
Although no fetal adverse events were reported in animal studies, adequate and well-controlled studies of Technivie treatment in pregnant women are lacking. Therefore, Technivie should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
However, when Technivie is administered with ribavirin, the combination regimen should not be used in pregnant women and in men who can father children. Ribavirin is known to cause birth defects and should be avoided during pregnancy.
It is not known whether Technivie is excreted into human milk. Due to the lack of conclusive safety data, Technivie should be used cautiously in nursing mothers.
What else should I know about Technivie?
What preparations of Technivie are available?
Oral tablets each containing 12.5 mg ombitasvir, 75 mg paritaprevir, and 50 mg ritonavir.
How should I keep Technivie stored?
Technivie tablets should be stored at room temperature, between 15 and 30 C (59 F and 86 F).
Technivie (ombitasvir, paritaprevir and ritonavir) is a combination drug prescribed to treat heptatitis C in patients without liver cirrhosis. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication
Multimedia: Slideshows, Images & Quizzes
Hepatitis C Quiz: What is Hepatitis C?
How many Americans have hepatitis C? Take this quiz to learn the facts about this chronic disease....
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function....
Picture of Liver
Front View of the Liver. The liver is a large, meaty organ that sits on the right side of the belly. See a picture of the Liver...
Hepatitis: How Do You Get Hepatitis A, B, and C?
Hepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver...
Hepatitis C (Hep C) Symptoms and Treatment
What is Hepatitis C (Hep C, HVC)? Learn about hepatitis c symptoms, how you get hepatitis c, contagiousness, and hepatitis C...
Related Disease Conditions
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation,...
Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral...
Hepatitis (Viral Hepatitis, A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or...
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion,...
Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as: gallstones, high...
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like: fatigue,...
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of...
Hepatitis C Cure (Symptoms, Transmission, Treatments, and Cost)
Hepatitis is inflammation of the liver. There are a variety of toxins, diseases, illicit drugs, medications, bacterial and viral...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.