- What is Technivie, and how does it work (mechanism of action)?
- What brand names are available for Technivie?
- Is Technivie available as a generic drug?
- Do I need a prescription for Technivie?
- What are the side effects of Technivie?
- What is the dosage for Technivie?
- Which drugs or supplements interact with Technivie?
- Is Technivie safe to take if I'm pregnant or breastfeeding?
- What else should I know about Technivie?
What is Technivie, and how does it work (mechanism of action)?
: Technivie is a combination oral medication containing ombitasvir, paritaprevir, and ritonavir. Technivie is used with ribavirin (Rebetol) to treat genotype 4 hepatitis C virus (HCV) infections in patients without liver cirrhosis. Technivie belongs to a class of drugs called direct-acting antiviral agents. Similar drugs include
- boceprevir (Victrelis),
- sofosbuvir (Sovaldi),
- simeprevir (Olysio),
- telaprevir (Incivek), and
- ombitasvir, paritaprevir, ritonavir, and dasabuvir (Viekira Pak).
Ombitasvir and paritaprevir are antivirals that have direct activity against HCV. They block the effect of proteases which are enzymes that HCV uses for making new viruses, leading to reduced numbers of HCV copies in the body. Ombitasvir blocks HCV NS5A protease while paritaprevir blocks HCV NS3/4A protease. The third medicine in Technivie, ritonavir, is not active against the HCV virus. It is used to increase blood levels of paritaprevir by inhibiting the breakdown of paritaprevir.
The combination of Technivie and ribavirin for 12 weeks resulted in 100% cure rates in patients with genotype 4 chronic HCV without cirrhosis. Cure was defined as undetectable levels of HCV in the body 3 months after treatment had ended. The FDA approved Technivie in July 2015.
What are the side effects of Technivie?
- Technivie may cause an abnormal increase in liver enzymes, especially in females taking ethinyl estradiol-containing medications such as combined oral contraceptives or contraceptive patches or contraceptive vaginal rings. Ethinyl estradiol-containing medications must be stopped before starting treatment with Technivie.
- Warnings and precautions for ribavirin should be followed because it is used in combination with Technivie.
- Ritonavir, a component of Technivie is an HIV protease inhibitor used to treat HIV infections. Any person infected with both HCV and HIV and are treated with Technivie should also receive antiretroviral HIV treatment to reduce the risk of HIV drug resistance.
Quick GuideHepatitis C (Hep C) Symptoms and Treatment
What is the dosage for Technivie?
- The recommended dose of Technivie is two tablets by mouth once daily with the morning meal. Technivie is used in combination with another HCV medication called ribavirin. The dosage of ribavirin is based on weight and usually is administered twice daily with food. Adults with genotype 4 infection without cirrhosis should receive 12 weeks of Technivie plus ribavirin.
- Alternatively, some patients who are unable to tolerate ribavirin may be treated with Technivie alone for 12 weeks.
- Technivie is not recommended for patients with moderate or severe liver disease.
Which drugs or supplements interact with Technivie?
Technivie interacts with many drugs. The prescribing information should be consulted for a complete list of drugs that interact with Technivie. Technivie should not be used with the following medications:
- Afluzosin hydrochloride (Uroxatral), a medicine used to treat benign prostate hyperplasia (BPH), due to the risk of hypotension (low blood pressure).
- Certain anti-seizure medications, including carbamazepine (Tegretol), phenytoin (Dilantin), and phenobarbital (Luminal), which may decrease the blood concentrations of Technivie and reduce the effectiveness of treatment.
- Rifampin (Rifadin, Rimactane), a component of many regimens for treating tuberculosis, which may decrease the blood concentrations of Technivie, reducing the effectiveness of treatment.
- Ergot derivatives which are used to treat migraine headaches should not be used with Technivie due to the risk of ergot toxicity.
- Combination birth control pills that contain ethinyl estradiol should be avoided due to the potential for liver damage.
- St. John's Wort may decrease the blood concentrations of Technivie, resulting in reduced effectiveness of treatment.
- Commonly used cholesterol lowering agents, lovastatin (Mevacor) and simvastatin (Zocor), should be avoided due to the risk for serious muscle pain and injury, including rhabdomyolysis.
- Combining Technivie and pimozide (Orap) may increase the risk for abnormal heart beats.
- Combining efavirenz (Sustiva) and Technivie may increase the risk of liver damage.
- Combining Technivie with sildenafil (Viagra, Revatio) and similar drugs may increase the risk of vision problems, low blood pressure, fainting, and priapism (painful, long lasting erection).
- Technivie increases blood levels of triazolam (Halcion) and midazolam, leading to increased sedation and respiratory depression.
Is Technivie safe to take if I'm pregnant or breastfeeding?
Although no fetal adverse events were reported in animal studies, adequate and well-controlled studies of Technivie treatment in pregnant women are lacking. Therefore, Technivie should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
However, when Technivie is administered with ribavirin, the combination regimen should not be used in pregnant women and in men who can father children. Ribavirin is known to cause birth defects and should be avoided during pregnancy.
It is not known whether Technivie is excreted into human milk. Due to the lack of conclusive safety data, Technivie should be used cautiously in nursing mothers.
What else should I know about Technivie?
What preparations of Technivie are available?
Oral tablets each containing 12.5 mg ombitasvir, 75 mg paritaprevir, and 50 mg ritonavir.
How should I keep Technivie stored?
Technivie tablets should be stored at room temperature, between 15 and 30 C (59 F and 86 F).
Technivie (ombitasvir, paritaprevir and ritonavir) is a combination drug prescribed to treat heptatitis C in patients without liver cirrhosis. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication
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Top Technivie Related Articles
boceprevirBoceprevir (Victrelis) is an antiviral medication prescribed for the treatment of hepatitis C. Side effects, drug interactions, storage, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
CirrhosisCirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. This disease leads to abnormalities in the liver's ability to handle toxins and blood flow, causing:
- internal bleeding,
- kidney failure,
- mental confusion,
- body fluid accumulation, and
- frequent infections.
HarvoniLedipasvir and sofosbuvir (Harvoni) is a combination drug prescribed to treat chronic hepatitis C infection. Side effects, drug interactions, storage, dosing, and pregnancy information should be reviewed prior to taking any medication.
Hepatitis CHepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Symptoms of chronic hepatitis include fatigue, fever, muscle aches, loss of appetite, and fever. Chronic hepatitis C may be cured in most individuals with drugs that target specific genomes of hepatitis C.
Hepatitis C Cure Symptoms and Treatment Costs
Hepatitis is inflammation of the liver. There are a variety of toxins, diseases, illicit drugs, medications, bacterial and viral infections, and heavy alcohol use can case inflammation of the liver. Hepatitis C viral infection (HCV) is one type of hepatitis. According to the CDC, in 2014 there were an estimated 30,500 cases of acute hepatitis C infections in the US. An estimated 2.7-3.9 million people in the US have chronic hepatitis C. The virus is spread from person-to-person via blood-to-blood contact. Symptoms of HCV infection include:
- Joint pain
- Dark urine
- Loss of appetite
- Clay colored stool
There are drugs that can cure most hepatitis C infections.
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- nausea and vomiting,
- anorexia, and
- abdominal discomfort.
Is Hepatitis ContagiousHepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of hepatitis are contagious and some types are not. Hepatitis symptoms vary upon the type of disease; however, the following symptoms may develop in someone with hepatitis: fatigue, nausea and vomiting, abdominal pain and discomfort, jaundice (yellowing of the skin and whites of the eyes), and loss of appetite. Treatment for hepatitis depends upon the cause. Some types of hepatitis have a vaccine to prevent spread of disease such as hepatitis A and B.
Liver (Anatomy and Function)The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation, scarring of the liver, infection of the liver, gallstones, cancer, toxins, genetic diseases, and blood flow problems. Symptoms of liver disease generally do not occur until the liver disease is advanced. Some symptoms of liver disease include jaundice, nausea and vomiting, easy bruising, bleeding excessively, fatigue, weakness, weight loss, shortness of breath, leg swelling, impotence, and confusion. Treatment of diseases of the liver depend upon the cause.
Liver DiseaseLiver disease can be cause by a variety of things including infection (hepatitis), diseases such as:
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Protease Inhibitors (PI) Drug Class
Protease Inhibitors (PIs) are a class of antiviral drugs prescribed to treat HIV and hepatitis (HCV) viral infections. There are several protease inhibitors that treat HIV infection, for example:
- Lexiva (fosamprenavir)
- Invirase (saquinavir)
- Kaletra (lopinavir/ritonavir)
- Viracept (nelfinavir)
- Norvir (ritonavir)
Examples of hepatitis C virus protease inhibitors include:
- Olysio (simeprevir)
- Technivie (ombitasvir/paritaprevir and ritonavir, a combination of these three drugs)
- Viekira Pak (ombitasvir/paritaprevir/ritonavir and dasabuvir, a combination of these four drugs)
Drug interactions, dosage, preparations, and pregnancy and breastfeeding safety should be reviewed prior to taking these drugs.
ritonavirRitonavir (Norvir) is a drug used in combination with other drugs for the treatment of HIV infection. Side effects, drug interactions, and dosing information should be reviewed prior to taking this medication.
simeprevirSimeprevir (Olysio) is an oral, direct-acting antiviral agent prescribed for treating infections with HCV (hepatitis C virus). Simeprevir is used in combination with ribavirin (Rebetol, Copegus) and peginterferon to treat hepatitis C infections. Drug interactions, warnings and precautions, side effects, and dosage information should be reviewed prior to taking this medication.
Sofosbuvir, brand name Sovaldi, is an antiviral medication prescribed for the treatment of the hepatitis C virus (HCV) genotypes 1, 2, 3, and 4 infection. It is used in combination with ribavirin plus interferon or ribavirin (Rebetol, Copegus). Common side effects include:
Drug interactions, dosing, and pregnancy and breastfeeding safety information should be reviewed with your treating physician prior to taking this medication.
telaprevirtelaprevir (Incivek) is an antiviral medication prescribed for the treatment of hepatitis C in adults with compensated liver disease and have not been treated prior, or have failed previous treatment. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication.
Viral HepatitisHepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or another virus (such as those that cause infectious mononucleosis, cytomegalovirus disease). The main nonviral causes of hepatitis are alcohol and drugs. Many patients infected with hepatitis A, B, and C have few or no symptoms of illness. For those who do develop symptoms of viral hepatitis, the most common are flu- like symptoms including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, and aching in the abdomen. Treatment of viral hepatitis is dependant on the type of hepatitis.