- What is tamoxifen (Soltamox)?
- Why is tamoxifen (Soltamox) prescribed to patients?
- What are the side effects of tamoxifen (Soltamox)?
- What is the dosage for tamoxifen (Soltamox)?
- Which drugs or supplements interact with tamoxifen (Soltamox)?
- Is tamoxifen (Soltamox) safe to use during pregnancy or while breastfeeding?
- What else should I know about tamoxifen (Soltamox)?
What is tamoxifen (Soltamox)?
Tamoxifen is an anti-estrogen that prevents the effects of estrogens on tissues.
What brand names are available for tamoxifen (Soltamox)?
Soltamox is currently the only brand available for tamoxifen. Nolvadex brand has been discontinued.
Is tamoxifen (Soltamox) available as a generic drug?
Do I need a prescription for tamoxifen (Soltamox)?
Why is tamoxifen (Soltamox) prescribed to patients?
- Tamoxifen is used for the treatment of invasive breast cancer in men and women, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it.
- Tamoxifen also is used for the treatment of women following surgery and radiation for a less common type of breast cancer called ductal carcinoma in situ (DCIS or intraductal carcinoma). Women who have had DCIS are at high risk for developing invasive breast cancer at a later date, and tamoxifen prevents development of the invasive cancer in almost half of the women during the first five years of treatment.
- Occasionally, tamoxifen is used to stimulate ovulation.
What are the side effects of tamoxifen (Soltamox)?
SIDE EFFECTS WARNING:
- Uterine malignancies, stroke, and pulmonary embolism were reported when tamoxifen was used for risk-reduction in women with ductal carcinoma in situ and women at high risk for breast cancer.
The most common side effects associated with tamoxifen are:
- Hot flashes
- Weight loss
- Abnormal or absence of menstrual periods
- Vaginal discharge
- Vaginal bleeding
- Fluid retention
- Bone pain
Serious side effects include:
- Tamoxifen is associated with blood clots leading to deep vein thrombosis and pulmonary embolism.
- Tamoxifen can cause abnormalities of liver tests, reduced white blood cells, red blood cells, and platelets. Reduced platelets can lead to bleeding. Patients should keep appointments for blood work to monitor for these side effects. Patients should report any suspected side effects immediately, especially bleeding and yellowing of the skin.
What is the dosage for tamoxifen (Soltamox)?
- The dose for metastatic breast cancer treatment, DCIS, and prevention of breast cancer is 10 mg twice daily or 20 mg once daily for 5 years.
- The dose for stimulation of ovulation is 5-40 mg twice daily for 4 days.
- Tamoxifen can be taken with food.
Which drugs or supplements interact with tamoxifen (Soltamox)?
Latest Cancer News
Daily Health News
Is tamoxifen (Soltamox) safe to use during pregnancy or while breastfeeding?
What else should I know about tamoxifen (Soltamox)?
What preparations of tamoxifen (Soltamox) are available?
- Tablets: 10 and 20 mg. Solution: 10 mg/5 ml
How should I keep tamoxifen (Soltamox) stored?
- Tamoxifen should be stored in a dry place at 15 C - 30 C (59 F - 86 F).
How does tamoxifen (Soltamox) work?
- The precise mechanism of its action is unknown, but one possibility is that it binds and blocks estrogen receptors on the surface of cells, preventing estrogens from binding and activating the cell. It is used in patients for treating and preventing breast cancer.
When was tamoxifen (Soltamox) approved by the FDA?
- Tamoxifen was approved by the FDA in December 1997.
Tamoxifen (Soltamox) is an anti-estrogen medication prescribed for the prevention and treatment of breast cancer in men and breast cancer in women. Tamoxifen also is prescribed to stimulate ovulation. Side effects include headache, vomiting, nausea, cough, fatigue, fluid retention, and bone pain.
Multimedia: Slideshows, Images & Quizzes
Breast Cancer Diagnosis and Treatment
Learn about breast cancer causes, symptoms, tests, recovery, and prevention. Discover the types of treatments such as surgery and...
Breast Cancer Quiz: Symptoms & Signs
This Breast Cancer Quiz features signs, symptoms, facts, causes, common forms, terms, risk factors, statistics, and more. ...
Picture of Breast Anatomy
The breast refers to the front of the chest or, more specifically, to the mammary gland. See a picture of Breast Anatomy and...
10 Things Young Women Should Know About Breast Cancer
Is breast cancer genetic? Should I get tested for the BRCA gene? What every young women should know about breast cancer. Discover...
Related Disease Conditions
Night Sweats (In Men and Women) Causes, Remedies, and Treatments
Night sweats are severe hot flashes that occur at night and result in a drenching sweat. The causes of night sweats in most people are not serious, like menopause in women, sleep apnea, medications, alcohol withdrawal, and thyroid problems. However, more serious diseases like cancer and HIV also can cause night sweats. Your doctor will treat your night sweats depending upon the cause. You may experience other signs and symptoms that are associated with night sweats, which depend upon the cause, but may include, shaking, and chills with a fever caused by an infection like the flu or pneumonia; unexplained weight loss due to lymphoma; women in perimenopause or menopause may also have vaginal dryness, mood swings, and hot flashes during the day; and low blood sugar in people with diabetes. Other causes of night sweats include medications like NSAIDs (aspirin, acetaminophen, ibuprofen (Motrin, Advil), and naproxen (Aleve, Naprosyn), antidepressants, sildenafil (Viagra), and abuse of prescription or illegal drugs and drug withdrawal; hormone disorders like pheochromocytoma and carcinoid syndrome; idiopathic hyperhidrosis; infections like endocarditis, AIDs, and abscesses; alcoholism and alcohol withdrawal; drug abuse, addiction, and withdrawal; and stroke. A doctor or other health care professional can treat your night sweats after the cause has been diagnosed.
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known. Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping. Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
Gynecomastia (Enlarged Male Breasts Symptoms, Causes, and Treatments)
Gynecomastia, an enlargement of the gland tissue in the male breast is caused by an imbalance of hormones. Certain medical conditions may also lead to gynecomastia such as cirrhosis, malnutrition, disorders of the male sex organs, kidney failure, thyroid disorders, and medications. Gynecomastia is generally treated with medication, and if necessary, surgery.
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
Though uterine cancer's cause is unknown, there are many factors that will put a woman at risk, including being over age 50, having endometrial hyperplasia, using hormone replacement therapy, obesity, using tamoxifen, being Caucasian, and/or having colorectal cancer. Symptoms and signs of cancer of the uterus (endometrial cancer) include abnormal vaginal bleeding, painful urination, painful intercourse, and pelvic pain. Treatment depends on staging and may include radiation therapy or hormone therapy.
Peyronie's Disease (Curvature of the Penis)
Peyronie's disease or curvature of the penis (Peyronie disease) is a condition in which scar tissue develops inside the penis. This scar tissue causes the penis to develop an abnormal curvature in the scarred area. At this time, there is no known cause of Peyronie's disease. Symptoms of Peyronie's disease include pain during intercourse or ejaculation, erectile dysfunction (ED, impotence), the inability to have sexual intercourse, anxiety, stress, an indentation of the shaft at the site where there is plaque or scarring, and an angulation of the penis when erect or flaccid. There is no cure for Peyronie's disease, however, there are medications that can reduce symptoms of the disease. Surgery or penile implants may be an option for severe cases.
Male Breast Cancer
Male breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's risk of developing breast cancer is one in 1,000. Signs and symptoms include a firm mass located below the nipple and skin changes around the nipple, including puckering, redness or scaling, retraction and ulceration of the nipple. Treatment depends upon staging and the health of the patient.
Inflammatory Breast Cancer
Inflammatory breast cancer is an accelerated form of breast cancer that is not usually detected by mammogram or ultrasound. Symptoms of inflammatory breast cancer include pain in the breast, skin change in the breast area, bruise on the breast,sudden swelling of the breast, nipple retraction or discharge, and swelling of the lymph nodes.
Paget Disease of the Breast (Paget's Disease of the Nipple)
Paget's disease is a rare form of cancer that forms in or around the nipple and frequently coexists with breast cancer. The exact cause of Paget's disease is unknown. Symptoms and signs include redness, scaling, and flaking of the nipple skin. A biopsy and imaging studies are needed to diagnose the disease. Treatment may include surgery, radiation, and adjuvant therapy.
Breast Cancer Prevention
Lifestyle changes, a healthy antioxidant-rich diet, exercise, and weight reduction can help reduce a woman's risk of developing breast cancer. It's important to be aware of how risk factors such as family history, lifestyle factors, breast conditions, radiation therapy, and hormonal factors may influence your chances of developing breast cancer. Mammography and breast self-examinations are crucial steps in breast cancer prevention.
Certain behavioral, lifestyle, and environmental factors contribute to cancer. Cancer prevention involves modifying these factors to decrease cancer risk. Tobacco use, alcohol consumption, physical inactivity, inadequate fruit and vegetable intake, and obesity increase the risk of certain cancers. Vaccines, genetic testing, and cancer screening also play a role in cancer prevention.
Endometrial Cancer Prevention
Endometrial cancer, or uterine cancer, affects the endometrium of the uterus. It's the most common invasive cancer of the female reproductive system. Risk factors include smoking, obesity, lack of exercise, taking estrogen-only hormone therapy, early menstruation, late menopause, and never being pregnant.
Treatment of Breast Cancer by Stages
Treatment of breast cancer depends upon the stage of the cancer at the time of diagnosis. Some of the various treatments include: hormone therapy, radiation therapy, surgery, chemotherapy, HER2-targeted therapy, neoadjuvant therapy, and adjuvant therapy.
Breast Cancer Questions to Ask the Doctor
A diagnosis of breast cancer can be overwhelming, so it's important to write down all your questions before meeting with your doctor.
Estimating Breast Cancer Risk: Questions and Answers
As breast cancer is the most diagnosed non-skin cancer in American women, it is important to know your breast cancer risk. Risk factors include age, age at menarche, age at first live birth, history of breast abnormalities, breast biopsies, race, and history or breast cancer among first-degree relatives.
Treatment & Diagnosis
- Breast Cancer FAQs
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Endometrial Cancer Symptoms
- Medication Disposal
- Dangers of Mixing Medications
- Osteoporosis - EVISTA..... Wellness for Women?
- Hormone Therapy in Survivors of Breast Cancer
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Tamoxifen at a Lower Dose Might Still Prevent Breast Cancer's Return
- Is Radiation Therapy Overused in Breast Cancer Care?
- Many Breast Cancer Survivors Don't Get Life-Extending Therapy
- Breast Density May Be Leading Indicator of Cancer Risk
- Beating Breast Cancer But Still Paying a Price
- Tamoxifen May Get Blamed for Unrelated Symptoms
- More Evidence Tamoxifen, Other Meds Help Limit Breast Cancer's Spread
- Tamoxifen OK for Breast Cancer Patients Without Uterine Abnormalities: Study
- Smoking May Hinder Common Breast Cancer Treatment
- Longer Use of Certain Drugs Cuts Recurrence for Breast Cancer Survivors
- Breast Cancer Meds Won't Raise Chances of Heart Attack, Stroke, Study Suggests
- Two Drugs Equal in Preventing Early Breast Cancer's Return: Study
- Experts Issue Guidelines on Caring for Breast Cancer Survivors
- Safe to Take Antidepressants With Tamoxifen: Study
- After Breast Cancer, Many in Appalachia Say No to Lifesaving Drugs
- Certain Generic Meds May Help Older Patients With Early Breast Cancer
- Genes Linked to Breast, Ovarian Cancers Act Differently in Each Woman: Study
- Breast Cancer Survivors May Have Higher Thyroid Cancer Risk
- Common Breast Biopsy Finding May Be More Dangerous Than Thought
- Gene Test May Help Predict Return of Early Breast Tumor, Study Says
- New Treatment Shows Promise in Younger Breast Cancer Patients: Study
- Male Breast Cancer Is Different
- Medicare Subsidy Helps Breast Cancer Patients Afford Treatment
- Rat Study Suggests Light at Night Might Hamper Breast Cancer Therapy
- Breast Cancer Drug Aromasin May Be Option for Some Premenopausal Women
- Older Breast Cancer Patients Do Follow Drug Therapy: Study
- Newer Anti-Estrogen Treatment May Benefit Younger Breast Cancer Survivors
- New Guidelines Recommend Longer Tamoxifen Treatment
- Drug May Help Slow Advanced Breast Cancer
- Drug Arimidex Cuts Risk for Breast Cancer in Older, High-Risk Women: Study
- Could a Neck Injection Ease Tough-to-Bear Hot Flashes?
- Tamoxifen's Mental Side Effects Are Real, Study Shows
- Researchers Focus on Likelihood of Breast Cancer Recurrence
- Most Women Don't Understand Their Breast Cancer Risk: Survey
- More Women Consider Gene Test After Angelina Jolie Mastectomy Revelation
- Women at High Breast Cancer Risk Should Consider Preventive Drugs: Experts
- First Non-Hormonal Remedy Approved for Menopausal Hot Flashes
- Which Women Might Benefit From Drugs to Prevent Breast Cancer?
- Doubling Time on Tamoxifen Cuts Odds for Breast Cancer's Return: Study
- Angelina Jolie Will Have Ovaries Removed to Lower Chances of Cancer: Report
- Mammograms Can Measure How Breast Cancer Drug Is Working: Study
- Drugs Can Cut Breast Cancer Risk for Some, Task Force Finds
- Menopause-Like Woes Hinder Breast Cancer Treatment: Study
- Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters
- Tofu-Rich Diet May Help Women With Lung Cancer Live Longer
- 10 Years of Tamoxifen Better Than 5: Study
- New Drug Regimens May Slow Advanced Breast Cancer
- Breast Cancer Drug Linked to Sexual Problems in Older Women
- Breast Cancer Drug Might Help Men on Prostate Cancer Therapy
- Breast Cancer Radiation for Older Women?
- New Guidelines to Help Breast Cancer Survivors
- Breast Cancer Drug May Weaken Bones, Study Finds
- Risk of Death From Certain Breast Cancers May Rise With Age
- 40 Years On, the Triumphs and Challenges of America's 'War on Cancer'
- Radiation May Also Lead to 'Chemo Brain'
- Obesity Linked to Worse Outcomes With Early Breast Cancer
- Is Chemo the Cause of Mental Fog After Breast Cancer?
- Tamoxifen May Cut Lung Cancer Deaths
- Aromatase Inhibitors May Raise Heart Risks
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information