- Lupus and Lupus Anticoagulant
- Drug-Induced Lupus
What is lupus?
Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body designed to fight infectious agents, such as bacteria and other foreign microbes. One of the ways the immune system fights infections is by producing antibodies that bind to the microbes. People with lupus produce abnormal antibodies, called autoantibodies, in their blood that target tissues within their own body rather than foreign infectious agents.
Because the antibodies and accompanying cells of inflammation can affect tissues anywhere in the body, lupus can affect a variety of areas. Lupus may cause disease of the skin, heart, lungs, kidneys, joints, and/or nervous system.
- When only the skin is involved by rash, the condition is called lupus dermatitis or cutaneous lupus erythematosus.
- A form of cutaneous lupus erythematosus that can be isolated to the skin, without internal disease, is called discoid lupus erythematosus.
- When internal organs are involved, the condition is referred to as systemic lupus erythematosus (SLE).
Both systemic lupus and discoid lupus are more common in women than men (about eight times more common). The disease can affect all ages but most commonly begins from 20-45 years of age. Lupus is somewhat more prevalent in African Americans and people of Chinese and Japanese descent.
Are lupus and lupus anticoagulant the same?
Lupus and lupus anticoagulant are not the same. If you have lupus, you don’t necessarily have lupus anticoagulant.
Lupus is an autoimmune condition and lupus anticoagulant is a type of antiphospholipid antibody syndrome, not a form of lupus.
Lupus anticoagulant refers to antiphospholipid antibody syndrome, or the presence of certain antiphospholipid antibodies in your body. If you have one or more varieties of this category of antibodies, you have a higher-than-average chance of developing blood clots and can exhibit some common side effects. If you have both lupus and lupus anticoagulant, you may still show symptoms of one while the other is under control.
Don’t be misled by the name — an anticoagulant is something that makes it harder for the blood to clot, but lupus anticoagulant actually makes it easier for the blood to clot. As mentioned before, you can have lupus anticoagulant without having lupus. Both parts of the name come from old misconceptions about the antibody developed when it was first discovered in the 1940s.
What are the four types of lupus?
The four types of lupus are:
- Systemic lupus erythematosus (SLE): This type of lupus affects the internal organs and is the most serious type.
- Drug-induced lupus: This type of lupus occurs as a result of an overreaction to certain medications such as Apresoline (hydralazine) or quinidine and Pronestyl (procainamide). It is similar to SLE.
- Lupus dermatitis: Lupus affecting the skin in the form of a rash.
- Neonatal lupus: Lupus affecting an infant as a result of passively acquiring antibodies from a mother with SLE.
What causes lupus?
Lupus is not caused by an infectious microorganism and is not contagious from one person to another.
How do you get lupus?
Genetic factors increase the tendency of developing autoimmune diseases, and autoimmune diseases such as lupus, rheumatoid arthritis, and autoimmune thyroid disorders are more common among relatives of people with lupus than in the general population. It is also possible for one person to have more than one autoimmune disease and overlap syndromes of lupus and rheumatoid arthritis, or lupus and scleroderma, etc., can occur.
Some scientists believe the immune system in lupus is more easily stimulated by external factors like viruses or ultraviolet light. Sometimes, symptoms of lupus can be triggered or aggravated by only a brief period of sun exposure.
It also is known that some women with systemic lupus erythematosus can experience worsening of their symptoms before their menstrual periods. This phenomenon, together with the female predominance of systemic lupus erythematosus, suggests female hormones play an important role in the expression of SLE. This hormonal relationship is an active area of ongoing study by scientists.
Several factors make a person more likely to develop lupus:
- Female gender
- Childbearing age
- African American
- Asian American
- Native American
- Pacific Islander
- Having a family member with lupus (genetics)
Research has demonstrated evidence that a key enzyme's failure to dispose of dying cells may contribute to the development of systemic lupus erythematosus. The enzyme, DNase1, normally eliminates what is called "garbage DNA" and other cellular debris by chopping them into tiny fragments for easier disposal. Researchers turned off the DNase1 gene in mice. The mice appeared healthy at birth, but after six to eight months, the majority of mice without DNase1 showed signs of systemic lupus erythematosus. Thus, a genetic mutation in a gene that could disrupt the body's cellular waste disposal may be involved in the initiation of systemic lupus erythematosus.
What are the symptoms of lupus?
People with SLE can develop different combinations of symptoms and organ involvement.
12 lupus symptoms and signs
Common lupus complaints and symptoms and signs include
- fatigue or feeling tired,
- low-grade fever,
- loss of appetite,
- joint pain,
- muscle aches,
- hair loss (alopecia),
- ulcers of the mouth and nose,
- facial rash (butterfly rash),
- rashes caused by exposure to sunlight (photosensitivity),
- chest pain caused by inflammation of the lining that surrounds the lungs (pleuritis) and the heart (pericarditis), and
- poor circulation to the fingers and toes with cold exposure (Raynaud's phenomenon).
Complications of organ involvement can lead to further symptoms that depend on the organ affected and the severity of the disease.
What is lupus fatigue?
Fatigue is the most common symptom of systemic lupus erythematosus (SLE). According to one study, 40% of people with SLE suffer from persistent, severe fatigue. People with lupus have described lupus fatigue as feeling completely exhausted even after having a good night’s sleep or even with minimal exertion, such as making breakfast or showering. Lupus fatigue can be overwhelming and make it hard to do everyday activities.
The most common causes of lupus fatigue include:
- Flare-ups caused by the release of inflammatory chemicals in the body
- Thyroid imbalance
- Side effects of medications
- Gastrointestinal issues
- Depression and anxiety
- Stress or overexertion
- Lack of sleep caused by pain and other symptoms
- Low vitamin D levels
- Fibromyalgia, which is a separate disease that some patients with lupus experience
Speak with your doctor about lupus fatigue to evaluate the possible cause and provide appropriate treatment to reduce symptoms.
How do I know if my rash is lupus?
Over half of the people with SLE develop a characteristic red, flat facial rash over the bridge of their nose. Because of its shape, it is frequently referred to as the butterfly rash of SLE. The rash is painless and does not itch. The facial rash, along with inflammation in other organs, can be precipitated or worsened by exposure to sunlight, a condition called photosensitivity. This photosensitivity can be accompanied by worsening inflammation throughout the body, called a flare of the disease.
SLE-associated skin manifestations can sometimes lead to scarring. In discoid lupus, only the skin is typically involved. The skin rash in discoid lupus often is found on the face and scalp. It usually is red and may have raised borders. Discoid lupus rashes are usually painless and do not itch, but scarring can cause permanent hair loss (alopecia). Over time, 5%-10% of those with discoid lupus may develop SLE.
Typically, with treatment, this rash can heal without permanent scarring.
What besides lupus can cause a butterfly rash?
A rash across the middle section of your face in the shape of a butterfly, might be a malar rash. Malar rashes are often a symptom of an underlying health condition, often associated with lupus.
Having a butterfly rash isn’t always a sign that you have lupus. There are other conditions that affect the skin and cause redness in the center of the face.
Rosacea is another common cause of a malar rash. Rosacea is a chronic skin condition that causes redness and irritation on the face. It usually affects adults, though children can have rosacea as well.
People with rosacea have persistent redness on their faces. It might look like flushed skin or sunburn that doesn’t go away. Rosacea can cause bumps and pimples, thickened skin, and eye irritation. Some people have visible blood vessels in their faces as well or report dry skin or skin that stings or burns.
The root cause of rosacea isn’t clear. Doctors can treat the symptoms of the condition, usually with prescription medication that reduces the inflammation. In some cases, laser treatments help with symptoms. Using gentle skincare products and staying out of the sun can help prevent flare-ups.
Erysipelas is a type of skin infection, sometimes called cellulitis. It’s usually caused by group A streptococcal bacteria, particularly Streptococcus pyogenes. The condition happens when the bacteria get into an injury on the skin, such as a burn or scratch.
Erysipelas causes the skin around the original injury to become raised, red, and sometimes warm to the touch. You may feel pain or discomfort. Without treatment, the infection can make you feel sick. Other symptoms include fever, chills, headache, nausea, and a feeling of being run-down.
Doctors can typically diagnose erysipelas by examining the rash. They may perform a skin scraping that a lab can analyze to see which bacteria is causing the infection. They will prescribe antibiotics to clear up the infection.
Arthritis and inflammation with lupus
Most SLE patients will develop arthritis during the course of their illness. Arthritis from SLE commonly involves swelling, pain, stiffness, and even deformity of the small joints of the hands, wrists, and feet. Sometimes, the arthritis of SLE can mimic that of rheumatoid arthritis (another autoimmune disease).
More serious organ involvement with inflammation occurs in the brain, liver, and kidneys. White blood cells can be decreased in SLE (referred to as leukopenia or leucopenia). Also, a decrease in the number of blood-clotting factors called platelets (thrombocytopenia) can be caused by lupus. Leukopenia can increase the risk of infection, and thrombocytopenia can increase the risk of bleeding. Low red blood cell counts (hemolytic anemia) can occur.
Inflammation of muscles (myositis) can cause muscle pain and weakness. This can lead to elevations of muscle enzyme levels in the blood.
Inflammation of blood vessels (vasculitis) that supply oxygen to tissues can cause isolated injury to a nerve, the skin, or an internal organ. The blood vessels are composed of arteries that pass oxygen-rich blood to the tissues of the body and veins that return oxygen-depleted blood from the tissues to the lungs. Vasculitis is characterized by inflammation with damage to the walls of various blood vessels. The damage blocks the circulation of blood through the vessels and can cause injury to the tissues that are supplied with oxygen by these vessels.
Inflammation of the lining of the lungs (pleuritis) with pain aggravated by deep breathing (pleurisy) and of the heart (pericarditis) can cause sharp chest pain. The chest pain is aggravated by coughing, deep breathing, and certain changes in body position. The heart muscle itself rarely can become inflamed (carditis). It has also been shown that young women with SLE have a significantly increased risk of heart attacks due to coronary artery disease.
Kidney inflammation in SLE (lupus nephritis) can cause leakage of protein into the urine, fluid retention, high blood pressure, and even kidney failure. This can lead to further fatigue and swelling (edema) of the legs and feet. With kidney failure, machines are needed to cleanse the blood of accumulated waste products in a process called dialysis.
- After Salmonella Cases Double in a Week, Cantaloupe Recall Expanded
- COVID Vaccines Curbed Pandemic-Linked Surge in Preemie Births
- Could a 'Brain Coach' Help Folks at Higher Risk for Alzheimer's?
- Early Promise for Stem Cell Therapy to Curb MS
- Internet Poses No Threat to Mental Health, Major Study Finds
- More Health News »
What are other less common symptoms of lupus?
Many people with SLE experience hair loss (alopecia). Often, this occurs simultaneously with an increase in disease activity. Hair loss can be patchy or diffuse and appear to be more like hair thinning.
Some people with SLE have Raynaud's phenomenon, which causes the blood vessels of the hands and feet to spasm, especially upon exposure to cold. The blood supply to the fingers and/or toes then becomes compromised, causing blanching, whitish and/or bluish discoloration, and pain and numbness in the exposed fingers and toes.
Other diseases and conditions that can accompany lupus include coronary heart disease, nonbacterial valvular heart disease, pancreatitis, esophagus disease with difficulty swallowing (dysphagia), swollen lymph nodes (lymphadenopathy), liver disease (lupoid hepatitis), infections, and a tendency to spontaneous blood clotting and thrombosis.
What are the neurological symptoms of lupus?
Involvement of the brain can cause personality changes, thought disorders (psychosis), seizures, and even coma. Lupus of the nervous system (neurologic lupus) can lead to nerve damage resulting in numbness, tingling, and weakness of the involved body parts or extremities. Brain involvement is referred to as lupus cerebritis.
1. Cognitive dysfunction
Cognitive dysfunction is the most common neurological symptom of neurolupus, affecting 80% of people with systemic lupus erythematosus (SLE). Signs may include:
- Cloudy (unclear) thinking
- Impaired memory
Causes of cognitive dysfunction may be abnormalities in blood flow that lead to decreased oxygen delivery to certain parts of the brain.
Usually, cognitive dysfunction doesn’t worsen over time, and there is no real treatment for the symptoms. Therapies that may help include cognitive therapy and counseling.
Treatment may include the following:
- Migraine prevention diet may be recommended.
- Nortriptyline can be used to reduce headache frequency and severity when diet alone is insufficient.
- Corticosteroids are usually recommended for true lupus headaches.
- General fatigue
- Non-restful sleep
The exact cause of fibromyalgia is unknown. However, it is believed to occur due to the rewiring of pain pathways that lead to the spinal cord and brain. As a result, the CNS experiences an enhanced sensitivity to pain signals.
To check for fibromyalgia, your doctor may touch several points on the muscles of your body. People with fibromyalgia often feel pain with light pressure applied to these sites.
Drugs approved for the treatment of fibromyalgia include:
Other ways to manage fibromyalgia symptoms include regular exercise, frequent rest times, and stress management.
4. Organic brain syndrome
Organic brain syndrome is a condition that leads to impaired brain function, likely due to brain edema secondary to autoimmunity. Some other names for this syndrome include cerebritis, encephalopathy, and acute confusional state.
This condition is usually diagnosed with the help of lumbar puncture and electroencephalography. Before confirming a diagnosis, the following conditions may be ruled out:
If lupus is the cause of organic brain syndrome, high-dose steroids may be recommended to combat the effects.
5. CNS vasculitis
CNS vasculitis is a rare complication of lupus that involves inflammation of blood vessels in the brain. Magnetic resonance angiography or computed tomography angiography of the brain can detect the presence of vasculitis. Treatment of CNS vasculitis involves use of high-dose steroids.
Seizures occur in 14%-25% of people with lupus. Some of the reasons for seizures associated with SLE include:
- Inflammation of blood vessels in the brain
- Clot formation
- Side effects of SLE drugs
Damage to the brain caused by lupus can lead to uncontrollable muscle movements, loss of consciousness, and periods of confusion. Steroids or anticonvulsant medications may be recommended to treat seizures.
7. Transverse myelitis
Myelitis refers to the inflammation of the spinal cord and occurs in 1% of people with lupus. Some of the symptoms include:
- Loss of sensation
- Loss of bowel and bladder control
- Paraplegia or inability to move the limbs
Treatment options for myelitis include:
9. Peripheral neuropathies
Peripheral neuropathies occur in about 18% of people with lupus due to nerve damage or inflammation. Common symptoms include:
- Severe pain
- Pins-and-needles sensation
Treatment options for neuropathy include:
- Other immunosuppressive drugs
Diagnosis of lupus
Since SLE patients can have a wide variety of symptoms and different combinations of organ involvement, no single blood test establishes the diagnosis of systemic lupus. To help doctors improve the accuracy of the diagnosis of SLE, 11 criteria closely related to the symptoms discussed above were established by the American College of Rheumatology. Some people suspected of having SLE may never develop enough criteria for a definite diagnosis. Other people accumulate enough criteria only after months or years of observation. When a person has four or more of these criteria, the diagnosis of SLE is strongly suggested. Nevertheless, the diagnosis of SLE may be made in some settings in people with only a few of these classical criteria, and treatment may sometimes be instituted at this stage. Of these people with minimal criteria, some may later develop other criteria, but many never do.
What are the 11 criteria for diagnosing lupus?
The following are 11 criteria used for diagnosing systemic lupus erythematosus:
- Malar rash (over the cheeks of the face)
- Discoid skin rash (patchy redness with hyperpigmentation and hypopigmentation that can cause scarring)
- Photosensitivity (skin rash in reaction to sunlight [ultraviolet light] exposure)
- Mucous membrane ulcers (spontaneous sores or ulcers of the lining of the mouth, nose, or throat)
- Arthritis (two or more swollen, tender joints of the extremities)
- Pleuritis or pericarditis (inflammation of the lining tissue around the heart or lungs, usually associated with chest pain upon breathing or changes of body position)
- Kidney abnormalities (abnormal amounts of urine protein or clumps of cellular elements called casts detectable with a standard urinalysis)
Note: Ultimately, in patients with kidney disease from systemic lupus erythematosus (lupus nephritis), a kidney biopsy may be necessary to both define the cause of the kidney disease as being lupus-related as well as to determine the stage of the kidney disease in order to optimally guide treatments. Kidney biopsies are often performed by fine-needle aspiration of the kidney under radiology guidance, but in certain circumstances, a kidney biopsy can be done during an open abdominal operation.
- Brain irritation (manifested by seizures [convulsions] and/or psychosis, referred to as "lupus cerebritis")
- Blood-count abnormalities: low white blood count (WBC) or red blood count (RBC), or platelet count on routine complete blood count testing; leukopenia, anemia, and thrombocytopenia, respectively. Each of these is detectable with standard complete blood count testing (CBC).
- Immunologic disorder (abnormal immune tests include anti-double-stranded DNA (anti-dsDNA) or anti-Sm [anti-Smith] antibodies, falsely positive blood test for syphilis, anticardiolipin antibodies, lupus anticoagulant, or positive LE prep test)
- Antinuclear antibody (positive ANA antibody testing [antinuclear antibodies in the blood])
In addition to the 11 criteria, other tests can be helpful in evaluating people with SLE to determine the severity of organ involvement. These include routine testing of the blood to detect inflammation (for example, the erythrocyte sedimentation rate, or ESR, and the C-reactive protein, or CRP), blood-chemistry testing, direct analysis of internal body fluids, and tissue biopsies. Abnormalities in body fluids (joint or cerebrospinal fluid) and tissue samples (kidney biopsy, skin biopsy, and nerve biopsy) can further support the diagnosis of SLE. The appropriate testing procedures are selected for the patient individually by the doctor.
Lupus is treated by internal medicine subspecialists called rheumatologists. Depending on whether or not specific organs are targeted, other health specialists who can be involved in the care of patients with lupus include
- dermatologists (skin specialist),
- nephrologists (kidney specialist),
- hematologists (blood specialist),
- cardiologists (heart specialist),
- pulmonologist (lung specialist), and
- neurologists (brain and nerve specialist).
It's not uncommon for a team of physicians to be coordinated by the treating rheumatologist together with the primary care doctor.
Subscribe to MedicineNet's General Health Newsletter
What is the treatment for lupus?
There is no cure for SLE. The goal of treatment is to relieve symptoms and protect organs by decreasing inflammation and/or the level of autoimmune activity in the body. The precise treatment is individualized. Many people with mild symptoms may need no treatment or only intermittent courses of anti-inflammatory medications. Those with more serious illness involving damage to internal organ(s) may require high doses of corticosteroids in combination with other medications that suppress the body's immune system.
People with SLE need more rest during periods of active disease. Researchers have reported that poor sleep quality was a significant factor in developing fatigue in people with SLE. These reports emphasize the importance for people and physicians to address sleep quality and the effect of underlying depression, lack of exercise, and self-care coping strategies on overall health. During these periods, carefully prescribed exercise is still important to maintain muscle tone and range of motion in the joints.
To protect from sun sensitivity, sunscreens, sun avoidance, and sun protection clothing are used. Certain types of lupus rash can respond to topical cortisone medications.
Nonsteroidal anti-inflammatory drugs (NSAIDs) help reduce inflammation and pain in muscles, joints, and other tissues. Examples of NSAIDs include aspirin, ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), and sulindac (Clinoril). Since the individual response to NSAIDs varies, it is common for a doctor to try different NSAIDs to find the most effective one with the fewest side effects. The most common side effects are stomach upset, abdominal pain, ulcers, and even ulcer bleeding. NSAIDs are usually taken with food to reduce side effects. Sometimes, medications that prevent ulcers while taking NSAIDs, such as misoprostol (Cytotec), are given simultaneously.
Corticosteroids are more potent than NSAIDs in reducing inflammation and restoring function when the disease is active. Corticosteroids are particularly helpful when internal organs are affected. Corticosteroids can be given by mouth, injected directly into the joints and other tissues, or administered intravenously. Unfortunately, corticosteroids have serious side effects when given in high doses over prolonged periods, and the doctor will try to monitor the activity of the disease to use the lowest doses that are safe. Side effects of corticosteroids include weight gain, thinning of the bones and skin, infection, diabetes, facial puffiness, cataracts, and death (necrosis) of the tissues in large joints (called avascular necrosis or AVN).
Hydroxychloroquine (Plaquenil) is an antimalarial medication found to be particularly effective for SLE patients with fatigue, skin involvement, and joint disease. Consistently taking hydroxychloroquine can prevent flare-ups of lupus. Side effects are uncommon but include diarrhea, upset stomach, and eye-pigment changes. Eye-pigment changes are rare but require monitoring by an ophthalmologist (eye specialist) during treatment with hydroxychloroquine. Researchers have found hydroxychloroquine significantly decreased the frequency of abnormal blood clots in people with systemic lupus and the effect seemed independent of immune suppression, implying that hydroxychloroquine can directly act to prevent blood clots. This study highlights an important reason for people and doctors to consider hydroxychloroquine for long-term use, especially for people with SLE who are at risk for blood clots in veins and arteries, such as those with phospholipid antibodies (cardiolipin antibodies, lupus anticoagulant, and false-positive venereal disease research laboratory test). This means not only that hydroxychloroquine reduces the chance for re-flares of SLE, but it can also be beneficial in thinning the blood to prevent abnormal excessive blood clotting. Hydroxychloroquine is commonly used in combination with other treatments for lupus.
For resistant skin disease, other antimalarial drugs, such as chloroquine (Aralen) or quinacrine, are considered and can be used in combination with hydroxychloroquine. Alternative medications for skin disease include dapsone and retinoic acid (Retin-A). Retin-A is often effective for an uncommon wart-like form of lupus skin disease. For more severe skin diseases, immunosuppressive medications are considered as described below.
Medications that suppress immunity (immunosuppressive medications) are also called cytotoxic drugs. They are sometimes referred to as chemotherapy because they are also used to treat cancer, generally in much higher doses than those used to treat lupus. Immunosuppressive medications are used for treating people with more severe manifestations of SLE, such as damage to internal organs. Examples of immunosuppressive medications include azathioprine (Imuran), cyclophosphamide (Cytoxan), chlorambucil (Leukeran), cyclosporine (Sandimmune), and the disease-modifying drug methotrexate (Rheumatrex, Trexall). All immunosuppressive medications can seriously depress blood-cell counts and increase the risk of infection and bleeding. Immunosuppressive medications may not be taken during pregnancy or conception because of the risk to the fetus. Other side effects are specific to each drug. For example, methotrexate can cause liver toxicity, while cyclosporine can impair kidney function.
Another immunosuppressant, mycophenolate mofetil (CellCept) has been used as an effective medication for lupus, particularly when it is associated with kidney disease. Mofetil has helped reverse active lupus kidney disease (lupus renal disease) and in maintaining remission after it is established. Its lower side-effect profile has an advantage over traditional immune-suppression medications.
In lupus patients with serious brain (lupus cerebritis) or kidney disease (lupus nephritis), plasmapheresis, a process of removing blood and passing the blood through a filtering machine, then returning the blood to the body with its antibodies removed, is sometimes used to suppress immunity. Serious lupus nephritis is treated aggressively because it can progress to end-stage kidney disease (ESKD). End-stage kidney damage from SLE requires dialysis and/or a kidney transplant.
Rarely, people with SLE can develop seriously low platelet levels, thereby increasing the risk of excessive and spontaneous bleeding. Since the spleen is believed to be the major site of platelet destruction, surgical removal of the spleen is sometimes performed to improve platelet levels. Other treatments have included plasmapheresis and the use of male hormones.
Plasmapheresis has also been used to remove certain harmful proteins (cryoglobulins) that can lead to vasculitis (inflammation of the blood vessels, which can cause damage to organs).
Research is indicating the benefits of rituximab (Rituxan) in treating lupus. Rituximab is an intravenously infused antibody that suppresses a particular white blood cell, the B cell, by decreasing its number in the circulation. B cells have been found to play a central role in lupus activity, and when they are suppressed, the disease tends toward remission. This may be particularly helpful for people with kidney disease.
Another B-cell-suppressing treatment is belimumab (Benlysta). Belimumab blocks the stimulation of the B cells (a B-lymphocyte stimulator or BLyS-specific inhibitor) and is approved for the treatment of adults with active autoantibody-positive systemic lupus erythematosus who are receiving standard therapy. Belimumab is also FDA-approved to treat lupus-related kidney disease in combination with mycophenolate mofetil.
Anifrolumab-fnia (Saphnelo) is a medication that was approved in 2021 by the FDA to treat SLE. Anifrolumab-fnia is indicated for the treatment of adult patients with moderate to severe systemic lupus erythematosus (SLE) who are receiving standard therapy. The medication is given intravenously, every 4 weeks. It is not indicated for severe active central nervous system lupus (such as cerebritis) or severe active lupus nephritis (serious kidney inflammation caused by lupus). Anifrolumab-fnia works differently than other lupus medications as it blocks type 1 interferon (IFN-1) activity. IFN-1 is elevated (upregulated) in SLE. By blocking the IFN-1 receptor, lupus activity is likely to improve, and it may be possible to decrease the use of steroid medication (prednisone). Anifrolumab-fnia may work best for arthritis caused by lupus and lupus skin rashes. Because anifrolumab-fnia is an immune-suppressing medication, there is an increased risk of infections and serious infections when taking the medication. Some patients had severe allergic reactions (anaphylaxis) in the studies. Patients being treated with anifrolumab-fnia should not receive live vaccines while under treatment with the medication.
While there is no specific lupus diet, scientists have found that low-dose diet supplementation with omega-3 fish oils could help patients with lupus by decreasing inflammation and disease activity and possibly decreasing heart-disease risk. It is generally recommended that patients with lupus eat a balanced diet that includes plant-based foods and lean sources of protein. It is very important for people with lupus to eat a healthy diet because it helps the body to function optimally.
DHEA (dehydroepiandrosterone) has been helpful in reducing fatigue, improving thinking difficulties, and improving the quality of life in people with SLE. Recent research indicates that DHEA diet supplementation has been shown to improve or stabilize signs and symptoms of SLE. DHEA is commonly available in health-food stores, pharmacies, and many groceries.
What are the complications of lupus?
SLE is a potentially serious illness with the involvement of numerous organ systems. However, it is important to recognize that most people with SLE lead full, active, and healthy lives. Periodic increases in disease activity (flares) can usually be managed by varying medications. Since ultraviolet light can precipitate and worsen flares, people with systemic lupus should avoid sun exposure. Sunscreens and clothing covering the extremities can be helpful. Abruptly stopping medications, especially corticosteroids, can also cause flares and should be avoided. People with SLE are at increased risk of infections as SLE-related complications, especially if they are taking corticosteroids or immunosuppressive medications. Therefore, any unexpected fever should be reported to medical professionals and evaluated.
The key to successful management of SLE is regular contact and communication with the doctor, allowing monitoring of symptoms, disease activities, and treatment of side effects.
What is the prognosis for lupus?
Overall, the outlook for people living with systemic lupus is improving each decade with the development of more accurate monitoring tests and treatments.
The role of the immune system in causing diseases is becoming better understood through research. This knowledge will be applied to design safer and more effective treatment methods. For example, completely revising the immune system of people with extremely aggressive treatments that virtually temporarily wipe out the immune system is being evaluated. Current studies involve immune eradication with or without the replacement of cells that can reestablish the immune system (stem-cell transplantation).
People with SLE are at a somewhat increased risk of developing cancer. The cancer risk is most dramatic for blood cancers, such as leukemia and lymphoma, but is also increased for breast cancer. This risk probably relates, in part, to the altered immune system that is characteristic of SLE. Women with SLE appear to be at increased risk for heart disease (coronary artery disease).
Landmark research has shown clearly that oral contraceptives do not increase the rate of flares of systemic lupus erythematosus. This important finding is opposite to what has been thought for years. Birth-control pills do not increase the risk for lupus flares. Note: Women who are at increased risk of blood clotting, such as women with lupus who have phospholipid antibodies (including cardiolipin antibody and lupus anticoagulant), should avoid birth-control pills or any estrogen medications.
Is lupus a fatal disease?
Though lupus is a lifelong disease with the potential to affect all organs, with recent advances in diagnosis and disease care, most people with lupus will live a normal life span.
Research shows that 80 to 90 percent of people with lupus live for more than 10 years after diagnosis. It is fatal in only 10 to 15 percent of cases. The rate of complications is higher if lupus starts at an early age (in the 20s or earlier).
Individuals living with SLE can improve their long-term prognosis by learning about the many aspects of the illness as well as closely monitoring their own health with their doctors.
What is drug-induced lupus?
Dozens of medications have been reported to trigger SLE.
What drugs cause drug-induced lupus?
Drugs most often involved in drug-induced lupus include:
- hydralazine (Apresoline) is used for high blood pressure;
- quinidine (Quinidine Gluconate, Quinidine Sulfate) and procainamide (Pronestyl, Procan-SR, Procanbid) are used for abnormal heart rhythms;
- phenytoin (Dilantin) is used for epilepsy;
- isoniazid (Nydrazid, Laniazid) is used for tuberculosis; and
- d-penicillamine (used for rheumatoid arthritis).
Classes of medications that have been connected to drug-induced lupus include:
- Antiarrhythmics (e.g., procainamide, quinidine)
- Antibiotics (e.g., minocycline)
- Anti-inflammatories (e.g., aspirin, naproxen)
- Antithyroid drugs
- Chemotherapy drugs
- Cholesterol drugs
- Hypertension drugs (e.g., hydralazine, diltiazem isoniazid)
- Proton pump inhibitors (e.g., omeprazole)
What are the symptoms of drug-induced lupus?
- Muscle aches
- Joint pain, occasionally accompanied by swelling
- Weight loss
- Sun sensitivity
- Inflammation that produces pain or discomfort around the lungs or heart
Does drug-induced lupus go away?
Fortunately, drug-induced SLE is infrequent (accounting for less than 5% of all patients with SLE) and usually resolves when the medications are discontinued.
How can systemic lupus erythematosus affect pregnancy or the newborn?
Lupus pregnancy presents unique challenges. Pregnant people with SLE are considered high-risk pregnancies. These pregnancies require interactive monitoring generally by a skilled rheumatologist together with an obstetrician expert in high-risk pregnancies. People with SLE who are pregnant require close observation during pregnancy, delivery, and the postpartum period. This includes fetal monitoring by the obstetrician during later pregnancy. These patients can have an increased risk of miscarriages (spontaneous abortions) and can have flares of SLE during pregnancy. The presence of phospholipid antibodies, such as cardiolipin antibodies or lupus anticoagulants, in the blood, can identify people at risk for miscarriages. Cardiolipin antibodies are associated with a tendency toward blood clotting. Pregnant patients with SLE who have cardiolipin antibodies or lupus anticoagulants may need blood-thinning medications (aspirin with or without low molecular weight heparin [Lovenox]) during pregnancy to prevent miscarriages. Other reported treatments include the use of intravenous gamma globulin for selected people with histories of premature miscarriage and those with low blood-clotting elements (platelets) during pregnancy. People who have had a previous blood-clotting event may benefit from the continuation of blood-thinning medications throughout and after pregnancy for up to six to 12 weeks, at which time the risk of clotting associated with pregnancy seems to diminish. Plaquenil has now been found to be safe for use to treat SLE during pregnancy. Corticosteroids, such as prednisone, are also safely used to treat certain manifestations of lupus during pregnancy.
Lupus antibodies can be transferred from the mother to the fetus and result in lupus illness in the newborn (neonatal lupus). This includes the development of low red cell counts (hemolytic anemia) and/or white blood cell counts (leucopenia) and platelet counts (thrombocytopenia) and skin rash. Problems can also develop in the electrical system of the baby's heart (congenital heart block). Occasionally, a pacemaker for the baby's heart is needed in this setting. Neonatal lupus and congenital heart block are more common in newborns of mothers with SLE who carry specific antibodies referred to as anti-Ro (or anti-SSA) and anti-La (or anti-SSB). (It is helpful for the newborn baby's doctor to be made aware if the mother is known to carry these antibodies, even before delivery. The risk of heart block is 2%; the risk of neonatal lupus is 5%.) Neonatal lupus usually clears after 6 months of age, as the mother's antibodies are slowly metabolized by the baby.
Health Solutions From Our Sponsors
"Antiphospholipid Syndrome." March 2019. American College of Rheumatology. <https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antiphospholipid-Syndrome>.
Firestein, Gary S., eds., et al. Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set, 11th Edition. Canada: Elsevier, 2021.
Grenn, Robert C., et al. "Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome." Ann Rheum Dis 76.2 July 18, 2016. <https://ard.bmj.com/content/76/2/450>.
Ordi-Ros, J., et al. "Enteric-coated mycophenolate sodium versus azathioprine in patients with active systemic lupus erythematosus: a randomised clinical trial." Ann Rheum Dis 76.9 Sept. 2017: 1575-1582.
Pons-Estel, G.J., et al. "Epidemiology of systemic lupus erythematosus." Expert Rev Clin Immunol. 13.8 Aug. 2017: 799-814.
Saphnelo (anifroolumab-fnia) [package insert]. Wilminigton, DE: AstraZeneca Pharmaceuticals LP; 2021.
Teruel, M. and M.E. Alarcon-Riquelme. "The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned." J Autoimmun 74 November 2016: 161-175.
Yuen HK, Cunningham MA. Optimal management of fatigue in patients with systemic lupus erythematosus: a systematic review. Ther Clin Risk Manag. 2014;10:775-786.
Berman JR. Lupus and Fatigue. Hospital for Special Surgery.
Solhjoo M, Goyal A, Chauhan K. Drug-Induced Lupus Erythematosus. [Updated 2022 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
Kauffman CL. Drug-Induced Lupus Erythematosus.
Lupus, Neurological Sequelae of; National Institute of Health; National Institute of Neurologic Disorders and Stroke; January 20, 2023.
Lupus Foundation of America: "Treating lupus: a guide" and “Prognosis and Life Expectancy”
Switzerland. World Health Organization
Mayo Clinic. Lupus.
U.S. Centers for Disease Control
Centers for Disease Control and Prevention. Diagnosing and Treating Lupus.
Cleveland Clinic. Lupus (Systemic Lupus Erythematosus).
Johns Hopkins Lupus Center. “How is lupus diagnosed?” "Antiphospholipid Antibodies." “Nervous System”
Hospital for Special Surgery: "Antiphospholipid Syndrome: An In-Depth Overview."
Mount Sinai: "Lupus anticoagulants and antiphospholipid antibodies."
American Osteopathic College of Dermatology: "Pellegra."
Johns Hopkins Medicine: "Dermatomyositis."
Naji Rad S, Vashisht P, Malar Rash, StatPearls Publishing, 2022.
National Organization for Rare Diseases: "Erysipelas."
National Rosacea Society: "All About Rosacea."
Top Systemic Lupus Related Articles
AnemiaAnemia is the condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased. There are several types of anemia such as iron deficiency anemia (the most common type), sickle cell anemia, vitamin B12 anemia, pernicious anemia, and aplastic anemia. Symptoms of anemia may include fatigue, malaise, hair loss, palpitations, menstruation, and medications. Treatment for anemia includes treating the underlying cause for the condition. Iron supplements, vitamin B12 injections, and certain medications may also be necessary.
Antinuclear Antibody TestAntinuclear antibodies (ANAs), unusual antibodies that can bind to certain structures within the nucleus of the cells, are found in patients whose immune system may be predisposed to cause inflammation against their own body tissues. ANAs are indicative of the potential presence of an autoimmune illness.
Body Pain: What Does It Mean When Your Whole Body Aches?Body aches are a symptom of the flu, arthritis, autoimmune disease, infections like Lyme disease, and other conditions. Body pain and muscle aches may accompany fever, headache, and other symptoms. Body aches are a general symptom of many potential underlying conditions. Only a doctor can diagnose and treat the cause.
C-Reactive Protein (CRP) TestC-reactive protein (CRP) is a blood test that doctors can use to detect the risk of heart disease, heart attack, stroke, and peripheral arterial disease. CRP is a highly reactive protein that is found when there is general inflammation within the body.
Complete Blood Count (CBC)A complete blood count (CBC) is a calculation of the cellular makeup of blood. A CBC measures the concentration of white blood cells, red blood cells, platelets in the blood, and aids in diagnosing conditions and disease such as malignancy, anemia, or blood clotting problems.
Facial Health: What Your Skin and Face Symptoms Can Reveal About YouWhat medical problems appear on your face? Look into the mirror and find out. Jaundice, glaucoma, skin cancer, and cracked lips are just some of the many health conditions with symptoms that show on your face. Learn to spot common face conditions and safeguard your family’s health.
Kidney (Renal) Failure
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure include sepsis, medications, rhabdomyolysis, multiple myeloma, and acute glomerulonephritis.
Post renal causes of kidney failure include bladder obstruction, prostate problems, tumors, or kidney stones.Treatment options included diet, medications, or dialysis.
Lupus SlideshowWhat is Lupus? Learn about lupus symptoms like butterfly rash, joint pain and fatigue. Find causes, diagnosis, and treatments for lupus, a disease most commonly found in women.
Most Expensive Medical ConditionsWhat are the most expensive medical conditions? Learn about heart conditions, brain disorders, back pain and many more expensive health conditions. Discover the tips that can prevent serious medical problems and protect your financial well-being.
MRI (Magnetic Resonance Imaging Scan)MRI (or magnetic resonance imaging) scan is a radiology technique which uses magnetism, radio waves, and a computer to produce images of body structures. MRI scanning is painless and does not involve X-ray radiation. Patients with heart pacemakers, metal implants, or metal chips or clips in or around the eyes cannot be scanned with MRI because of the effect of the magnet.
Peripheral NeuropathyPeripheral neuropathy is a problem with the functioning of the nerves outside of the spinal cord. Symptoms may include numbness, weakness, burning pain (especially at night), and loss of reflexes. Possible causes may include carpel tunnel syndrome, shingles, vitamin or nutritional deficiencies, and illnesses like diabetes, syphilis, AIDS, and kidney failure. Peripheral neuropathy is diagnosed with exams and tests. Treatment for the condition depends on the cause. Usually, the prognosis for peripheral neuropathy is good if the cause can be successfully treated or prevented.
Skin RashThe word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different skin conditions. The most common of these are scaly patches of skin and red, itchy bumps or patches all over the place.
Lupus Pictures 1Systemic Lupus Erythematosus. Systemic lupus erythematosus is the most common form of the autoimmune disease lupus. This red scaly rash on a person's cheek is typical. SLE affects the skin and other internal organs. It’s possible for the heart, lungs and brain to become involved, followed by the formation of scar tissue (fibrosis). SLE is usually treated with corticosteroids.
Lupus QuizThis Lupus Quiz covers causes, signs, symptoms, facts, and treatments for this inflammatory autoimmune disease.
Thyroid Peroxidase TestThe thyroid peroxidase test measures the level of an antibody that is directed against thyroid peroxidase (TPO). The presence of TPOAb in the blood reflects a prior attack by the body's immune system on thyroid tissue. A positive thyroid peroxidase test may signal chronic thyroiditis. Other autoimmune disorders, however, may have a positive TPOAb test.
What Are the 11 Criteria for Lupus?Lupus is a multi-organ autoimmune disease in which your body's immune cells attack your own organs or tissues and can produce a variety of symptoms in different individuals. If you have any four out of the 11 criteria, then you are recognized to have lupus.