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- Suprax (cefixime) vs. Rocephin (ceftriaxone): What's the difference?
- What are Suprax and Rocephin?
- What are the side effects of Suprax and Rocephin?
- What is the dosage of Suprax vs. Rocephin?
- What drugs interact with Suprax and Rocephin?
- Are Suprax and Rocephin safe to use while pregnant or breastfeeding?
Suprax (cefixime) vs. Rocephin (ceftriaxone): What's the difference?
- Suprax (cefixime) and Rocephin (ceftriaxone) are cephalosporin antibiotics used to treat infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea.
- Suprax is also used to treat acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).
- Rocephin is also used to treat meningitis and as prophylaxis to reduce the incidence of postoperative infections in patients undergoing surgical procedures.
- Suprax is a brand name for cefixime.
- Rocephin is a brand name for ceftriaxone.
- Side effects of Suprax and Rocephin that are similar include nausea, vomiting, skin rash, fever, vaginitis, itching, headaches, and dizziness.
- Side effects of Suprax that are different from Rocephin include diarrhea, abdominal pain, joint pain, and abnormal liver tests.
- Side effects of Rocephin that are different from Suprax include injection site reactions (pain, swelling, tenderness, warmth), chills, high or low white blood cell counts, elevated platelets, anemia, changes in taste, sweating, and flushing.
What are Suprax and Rocephin?
Suprax is a cephalosporin antibiotic used to treat infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Other cephalosporins include cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and injectable forms. Like other cephalosporins, Suprax stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; most bacteria cannot survive without a cell wall. Suprax is active against a wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae.
Rocephin is a cephalosporin antibiotic used to treat respiratory tract infections, middle ear infections (otitis media), urinary tract infections (UTIs), skin and skin structure infections, gonorrhea, and bone and joint infections. It is also used to treat meningitis and as prophylaxis to reduce the incidence of postoperative infections in patients undergoing surgical procedures.
What are the side effects of Suprax and Rocephin?
Common side effects of Suprax include:
Other side effects include:
Do not use this medicine if you have ever had a severe allergic reaction to Rocephin or any other cephalosporin antibiotic. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads, and blistering and peeling).
Call your doctor at once if you have any of the following side effects:
- A seizure (convulsions)
- Severe stomach pain, diarrhea that is watery or bloody
- Sudden weakness or ill feeling, fever, chills, cold or flu symptoms, mouth sores
- Pale or yellowed skin, dark colored urine
- Severe pain in your upper stomach that comes and goes or spreads to your back
- A blood cell disorder -- skin rash or tight feeling, severe tingling or numbness, pain, muscle weakness
- Kidney or bladder problems -- pain in your side or lower back spreading to your groin, blood in your urine, painful or difficult urination, little or no urine
Common side effects may include:
- Mild diarrhea
- Warmth, tight feeling, or a hard lump where the injection was given
- Vaginal itching or discharge
- Abnormal liver function tests
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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What is the dosage of Suprax vs. Rocephin?
- The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours.
- Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
- The usual adult daily dose is 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4 grams.
- Rocephin is injected into a muscle or into a vein through an IV.
- A health care professional will give you this injection when Rocephin is used to prevent infection from surgery.
- You may be shown how to use an IV at home to treat an infection. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
- Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
What drugs interact with Suprax and Rocephin?
- Probenecid (Benemid) may increase the blood concentration of Suprax by decreasing removal of Suprax by the kidney. This interaction sometimes is used to enhance the effect of cephalosporins.
- Combining Suprax with aminoglycosides -- for example, tobramycin (Tobradex) -- produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.
- Exenatide (Byetta) may delay or reduce the absorption of cephalosporins. Cephalosporins should be administered one hour before exenatide.
- Suprax may cause a false positive urine ketone test.
- Rocephin must not be administered simultaneously with calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition via a Y-site. However, in patients other than neonates, Rocephin and calcium-containing solutions may be administered sequentially of one another if the infusion lines are thoroughly flushed between infusions with a compatible fluid.
- Other drugs may interact with Rocephin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
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Are Suprax and Rocephin safe to use while pregnant or breastfeeding?
- Safety in pregnancy has not been established for Suprax. There are no adequate studies in pregnant women; however, studies in animals suggest no important effects on the fetus.
- Safety in nursing mothers has not been established. It is not known if Suprax is excreted in breast milk.
- Reproductive studies have been performed in mice and rats at doses up to 20 times the usual human dose and have no evidence of embryotoxicity, fetotoxicity or teratogenicity. In primates, no embryotoxicity or teratogenicity was demonstrated at a dose approximately 3 times the human dose.
- There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, this drug should only be used during pregnancy if clearly needed.
- Low concentrations of Rocephin are excreted in human milk. Exercise caution when administering Rocephin to a nursing woman.
Suprax and Rocephin are cephalosporin antibiotics used to treat infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea. Suprax is also used to treat acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Rocephin is also used to treat meningitis and as prophylaxis to reduce the incidence of postoperative infections in patients undergoing surgical procedures.
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Related Disease Conditions
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Pneumonia (Symptoms, Causes, Types, Treatment, and Recovery)
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Upper Respiratory Tract Infection (URTI)
An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.
Tonsillitis is a contagious infection with symptoms of bad breath, snoring, congestion, headache, hoarseness, laryngitis, and coughing up blood. Tonsillitis can be caused acute infection of the tonsils, and several types of bacteria or viruses (for example, strep throat or mononucleosis). There are two types of tonsillitis, acute and chronic. Acute tonsillitis lasts from one to two weeks while chronic tonsillitis can last from months to years. Treatment of tonsillitis and adenoids include antibiotics, over-the-counter medications, and home remedies to relieve pain and inflammation, for example, salt water gargle, slippery elm throat lozenges, sipping warm beverages and eating frozen foods (ice cream, popsicles), serrapeptase, papain, and andrographism Some people with chronic tonsillitis may need surgery (tonsillectomy or adenoidectomy).
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which inflames the vocal cords. Symptoms may vary from degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup). Common symptoms include a "barky" cough, a hoarse cough, fever, cold, runny nose, dry cough, and loss of voice. Chronic laryngitis generally lasts more than three weeks. Causes other than infection include smoking, excess coughing, GERD, and more. Treatment depends on the cause of laryngitis.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Gonorrhea In Women
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Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Bronchitis (Acute) Contagoius Symptoms, Causes, Treatment, and Recovery Time
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is is short in duration (10 to 20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
Chronic Bronchitis (Symptoms, Causes, Treatment, Remedies)
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least three months, two years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
Treatment & Diagnosis
- Swollen Tonsils
- Urinary Tract Infection (UTI)
- Upper Respiratory Infection
- Middle Ear Infection (Otitis Media)
- Sore Throat (Pharyngitis)
- Strep Throat
- How to Choose a Doctor
- Doctor: Checklist to Take To Your Doctor's Appointment
- Doctor: Getting the Most from Your Doctor's Appointment
- Urinary Tract Infection FAQs
- Strep Streptococcal Throat Infection FAQs
- Ear Infection FAQs
- How Do You Get Staph Infection?
- What Causes an Ear Infection?
- How Do You Get an Ear Infection?
- How to Get Rid of a Staph Infection
- Urinary Tract Infection (UTI) Symptoms
- E. coli Infection Facts
- Urinary Tract Infection (UTI) Treatment
Medications & Supplements
- Keflex (cephalexin)
- Cephalexin vs. Amoxicillin
- cefixime (Suprax)
- Cipro, XR (ciprofloxacin) vs. Keflex (cephalexin)
- cephradine - oral, Velosef
- Amoxicillin vs. Ceftriaxone
- Nitrofurantoin vs. Cephalexin
- Suprax (cefixime) vs. azithromycin
- Cefdinir vs. cefixime (Suprax) 3rd Generation Antibiotics
- Suprax (cefixime) vs. ofloxacin
- Suprax (cefixime) vs. cefuroxime
- Suprax (cefixime) vs. Keflex (cephalexin)
- Suprax (cefixime) vs. Augmentin
- Levaquin (levofloxacin) vs. Keflex (cephalexin)
- Suprax (cefixime) vs. cefpodoxime
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