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- Suprax (cefixime) vs. azithromycin: What's the difference?
- What are Suprax and azithromycin?
- What are the side effects of Suprax and azithromycin?
- What is the dosage of Suprax vs. azithromycin?
- What drugs interact with Suprax and azithromycin?
- Are Suprax and azithromycin safe to use while pregnant or breastfeeding?
Suprax (cefixime) vs. azithromycin: What's the difference?
- Suprax (cefixime) and azithromycin are antibiotics used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).
- Suprax and azithromycin are different types of antibiotics. Suprax is a cephalosporin antibiotic and azithromycin is a macrolide antibiotic.
- Suprax is a brand name for cefixime.
- Brand names of azithromycin include Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, and Zmax.
- Side effects of Suprax and azithromycin that are similar include diarrhea, nausea, abdominal pain, vomiting, skin rash, and vaginitis.
- Side effects of Suprax that are different from azithromycin include fever, joint pain, abnormal liver tests, itching, headaches, and dizziness.
- Side effects of azithromycin that are different from Suprax include nervousness, tongue discoloration, ringing in the ears, and indigestion.
What are Suprax and azithromycin?
Suprax (cefixime) is a cephalosporin antibiotic used to treat middle ear infections (otitis media), throat infections (pharyngitis), laryngitis, tonsillitis, bronchitis, pneumonia, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Other cephalosporins include cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefprozil (Cefzil), cefpodoxime (Vantin), and some injectable forms. Suprax stops bacteria from multiplying by preventing bacteria from forming walls that are necessary to protect the bacteria from their environment and to keep the contents of the bacterial cell together. Most bacteria cannot survive without a cell wall. Suprax is active against a wide spectrum of bacteria including Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, Hemophilus influenzae, E. coli, Moraxella catarrhalis, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae.
Azithromycin is a macrolide antibiotic related to clarithromycin (Biaxin) and erythromycin that is used to treat otitis media (middle ear infection), tonsillitis, laryngitis, bronchitis, pneumonia, sinusitis, uncomplicated skin and skin structure infections, Mycobacterium avium complex, acute bacterial flare-ups of chronic obstructive pulmonary disease (COPD), acute pelvic inflammatory disease, and certain sexually transmitted infectious diseases (STDs) such as nongonococcal urethritis and cervicitis. It is effective against a variety of bacteria including Streptococcus pneumoniae, Hemophilus influenzae, Mycoplasma pneumoniae, Staphylococcus aureus, Mycobacterium avium, and many others.
What are the side effects of Suprax and azithromycin?
Common side effects of Suprax include:
Other side effects include:
The most common side effects of azithromycin are:
Other possible side effects of azithromycin include:
Possible serious side effects of azithromycin include:
- Abnormal liver tests
- Cholestatic jaundice
- Steven-Johnson Syndrome
- Serious allergic reactions
- Abnormal heartbeats
Antibiotics can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting azithromycin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
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What is the dosage of Suprax vs. azithromycin?
- The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours.
- Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
- Azithromycin (except Zmax) can be taken with or without food, but food reduces stomach upset.
- Zmax should be taken on an empty stomach 1 hour before or 2 hours after a meal since food reduces its absorption.
- The adult azithromycin dose is 500-2000 mg in multiple or single doses.
- For most infections, azithromycin is taken once daily for a relatively short course of treatment (usually five days).
- The first dose is often a "double dose," twice as much as the remainder of the doses given.
- For acute bacterial sinusitis, azithromycin may be taken once daily for three days.
- Zmax usually is given as a single 2 g dose.
What drugs interact with Suprax and azithromycin?
- Probenecid (Benemid) may increase the blood concentration of Suprax by decreasing removal of Suprax by the kidney. This interaction sometimes is used to enhance the effect of cephalosporins.
- Combining Suprax with aminoglycosides -- for example, tobramycin (Tobradex) -- produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.
- Exenatide (Byetta) may delay or reduce the absorption of cephalosporins. Cephalosporins should be administered one hour before exenatide.
- Suprax may cause a false positive urine ketone test.
Are Suprax and azithromycin safe to use while pregnant or breastfeeding?
There are no adequate studies of azithromycin in pregnant women. Azithromycin should only be used during pregnancy if it is clearly necessary.
It is not known if azithromycin is secreted in breast milk.
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Suprax and azithromycin are antibiotics used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).
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Related Disease Conditions
Sinus Infection (Sinusitis)
Sinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms are headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Pneumonia (Symptoms, Causes, Types, Treatment, and Recovery)
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Middle Ear Infection (Otitis Media)
Middle ear infection (otitis media) is inflammation of the middle ear. There are two forms of this type of ear infection, acute and chronic. Acute otitis media is generally short in duration, and chronic otitis media generally lasts several weeks. Babies, toddlers, and children with a middle ear infection may be irritable, pull and tug at their ears, and experience numerous other symptoms and signs. Treatment depends upon the type of ear infection.
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which inflames the vocal cords. Symptoms may vary from degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup). Common symptoms include a "barky" cough, a hoarse cough, fever, cold, runny nose, dry cough, and loss of voice. Chronic laryngitis generally lasts more than three weeks. Causes other than infection include smoking, excess coughing, GERD, and more. Treatment depends on the cause of laryngitis.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Gonorrhea In Women
Gonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
COPD (Chronic Obstructive Pulmonary Disease)
COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. Conditions that accompany COPD include chronic bronchitis, chronic cough, and emphysema. Symptoms of COPD include shortness of breath, wheezing, and chronic cough. Treatment of COPD includes GOLD guidelines, smoking cessation, medications, and surgery. The life expectancy of a person with COPD depends on the stage of the disease.
Is Tonsillitis Contagious?
Tonsillitis is a common infection, especially in kids. Tonsillitis is caused by viruses and bacteria like the flu and herpes simplex virus, and Streptococcus bacteria. These viruses and bacterium are spread person to person. Symptoms of tonsillitis are a yellow or white coating on the tonsils, throat pain, pain when swallowing, and hoarseness.
Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
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Bronchitis (Acute) Contagoius Symptoms, Causes, Treatment, and Recovery Time
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is is short in duration (10 to 20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
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Chronic Bronchitis (Symptoms, Causes, Treatment, Remedies)
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least three months, two years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
Is Sore Throat (Pharyngitis) Contagious?
The medical term for a sore throat is pharyngitis. There are many causes of a sore throat such as medications, diseases (GERD, cancer, AIDS), infections (Streptococcus or strep, mononucleosis), allergies, and smoking. Symptoms are a red, swollen throat; fever, and swollen lymph nodes. Treatment for sore throat depends on the cause.
Is Laryngitis Contagious?
Laryngitis is inflammation and swelling of the voice box (larynx). Causes of laryngitis are viral, bacterial, fungal, strenuous singing or talking, chemical irritants, and other underlying medical conditions. Symptoms of laryngitis are hoarseness, a weak or loss of voice, sore throat, dry throat, a tickling sensation in the back of the throat, or irritated or raw throat. Treatment of laryngitis depends upon the cause.
Shigellosis is a disease caused by the Shigella bacteria. Bloody diarrhea, stomach cramps, and fever are common symptoms. Mild infections usually resolve on their own. Antibiotics are used to treat more severe cases.
Treatment & Diagnosis
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- Urinary Tract Infection (UTI)
- Sinus Infection (Sinusitis)
- Middle Ear Infection (Otitis Media)
- Sore Throat (Pharyngitis)
- Strep Throat
- Chronic Obstructive Pulmonary Disease (COPD)
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